Ted Acott

Research Professor

  • 5694 Citations
  • 45 h-Index
1978 …2020
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Research Output 1978 2019

  • 5694 Citations
  • 45 h-Index
  • 97 Article
  • 2 Chapter
  • 1 Short survey
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Article
2019
1 Citation (Scopus)

GPR158 in the visual system: Homeostatic role in regulation of intraocular pressure

Itakura, T., Webster, A., Chintala, S. K., Wang, Y., Gonzalez, J. M., Tan, J. C., Vranka, J., Acott, T., Craft, C. M., Sibug Saber, M. E., Jeong, S., Stamer, W. D., Martemyanov, K. A. & Fini, M. E., May 1 2019, In : Journal of Ocular Pharmacology and Therapeutics. 35, 4, p. 203-215 13 p.

Research output: Contribution to journalArticle

Open Access
Ocular Hypertension
Intraocular Pressure
Trabecular Meshwork
Knockout Mice
Epinephrine
2018
2 Citations (Scopus)

Biomechanical rigidity and quantitative proteomics analysis of segmental regions of the trabecular meshwork at physiologic and elevated pressures

Vranka, J., Staverosky, J., Reddy, A. P., Wilmarth, P., David, L., Acott, T., Russell, P. & Raghunathan, V. K., Jan 1 2018, In : Investigative Ophthalmology and Visual Science. 59, 1, p. 246-259 14 p.

Research output: Contribution to journalArticle

Trabecular Meshwork
Proteomics
Pressure
Elastic Modulus
Extracellular Matrix Proteins
2 Citations (Scopus)

Glaucomatous cell derived matrices differentially modulate non-glaucomatous trabecular meshwork cellular behavior

Raghunathan, V. K., Benoit, J., Kasetti, R., Zode, G., Salemi, M., Phinney, B. S., Keller, K., Staverosky, J., Murphy, C. J., Acott, T. & Vranka, J., Jan 1 2018, (Accepted/In press) In : Acta Biomaterialia.

Research output: Contribution to journalArticle

Trabecular Meshwork
Extracellular Matrix
Military electronic countermeasures
Glaucoma
Tissue
2017
5 Citations (Scopus)

Estimating human trabecular meshwork stiffness by numerical modeling and advanced OCT imaging

Wang, K., Johnstone, M. A., Xin, C., Song, S., Padilla, S., Vranka, J., Acott, T., Zhou, K., Schwaner, S. A., Wang, R. K., Sulchek, T. & Ethier, C. R., Sep 1 2017, In : Investigative Ophthalmology and Visual Science. 58, 11, p. 4809-4817 9 p.

Research output: Contribution to journalArticle

Trabecular Meshwork
Optical Coherence Tomography
Atomic Force Microscopy
Elastic Modulus
Glaucoma
5 Citations (Scopus)

Tunneling nanotubes are novel cellular structures that communicate signals between trabecular meshwork cells

Keller, K., Bradley, J. M., Sun, Y. Y., Yang, Y. F. & Acott, T., Oct 1 2017, In : Investigative Ophthalmology and Visual Science. 58, 12, p. 5298-5307 10 p.

Research output: Contribution to journalArticle

Trabecular Meshwork
Nanotubes
Cellular Structures
Pseudopodia
Stress Fibers
2016
9 Citations (Scopus)
Trabecular Meshwork
Aminopropionitrile
Extracellular Matrix
Collagen Type I
Matrix Metalloproteinases
7 Citations (Scopus)

Pressure-induced expression changes in segmental flow regions of the human trabecular meshwork

Vranka, J. & Acott, T., Mar 15 2016, (Accepted/In press) In : Experimental Eye Research.

Research output: Contribution to journalArticle

Trabecular Meshwork
Extracellular Matrix
Pressure
Intraocular Pressure
Perfusion
2015
73 Citations (Scopus)
Trabecular Meshwork
Intraocular Pressure
Glaucoma
Extracellular Matrix
Aqueous Humor
37 Citations (Scopus)

Induced pluripotent stem cells restore function in a human cell loss model of open-angle glaucoma

Abu-Hassan, D. W., Li, X., Ryan, E. I., Acott, T. & Kelley, M., Mar 1 2015, In : Stem Cells. 33, 3, p. 751-761 11 p.

Research output: Contribution to journalArticle

Induced Pluripotent Stem Cells
Open Angle Glaucoma
Trabecular Meshwork
Intraocular Pressure
Stem Cells
29 Citations (Scopus)

Mapping molecular differences and extracellular matrix gene expression in segmental outflow pathways of the human ocular trabecular meshwork

Vranka, J., Bradley, J. M., Yang, Y. F., Keller, K. & Acott, T., Mar 31 2015, In : PLoS One. 10, 3, e0122483.

Research output: Contribution to journalArticle

Trabecular Meshwork
Microspheres
extracellular matrix
Gene expression
chromosome mapping
2014
28 Citations (Scopus)
Caveolin 2
Caveolins
Trabecular Meshwork
Caveolin 1
Extracellular Matrix
12 Citations (Scopus)

Interleukin-20 receptor expression in the trabecular meshwork and its implication in glaucoma

Keller, K., Yang, Y. F., Sun, Y. Y., Sykes, R., Gaudette, N. D., Samples, J. R., Acott, T. & Wirtz, M., Mar 1 2014, In : Journal of Ocular Pharmacology and Therapeutics. 30, 2-3, p. 267-276 10 p.

Research output: Contribution to journalArticle

Trabecular Meshwork
Glaucoma
Matrix Metalloproteinases
Mutation
Fibroblasts
40 Citations (Scopus)

Intraocular pressure homeostasis: Maintaining balance in a high-pressure environment

Acott, T., Kelley, M., Keller, K., Vranka, J., Abu-Hassan, D. W., Li, X., Aga, M. & Bradley, J. M., Mar 1 2014, In : Journal of Ocular Pharmacology and Therapeutics. 30, 2-3, p. 94-101 8 p.

Research output: Contribution to journalArticle

Intraocular Pressure
Homeostasis
Pressure
Glaucoma
Extracellular Matrix
2013
16 Citations (Scopus)
Ankyrin Repeat
Trabecular Meshwork
Ubiquitin
Cytokines
HSP70 Heat-Shock Proteins
14 Citations (Scopus)

The effects of tenascin C knockdown on trabecular meshwork outflow resistance

Keller, K., Vranka, J., Haddadin, R. I., Kang, M. H., Oh, D. J., Rhee, D. J., Yang, Y. F., Sun, Y. Y., Kelley, M. & Acott, T., 2013, In : Investigative Ophthalmology and Visual Science. 54, 8, p. 5613-5623 11 p.

Research output: Contribution to journalArticle

Trabecular Meshwork
Tenascin
Lentivirus
Intraocular Pressure
Pressure
2012
117 Citations (Scopus)

Current understanding of conventional outflow dysfunction in glaucoma

Stamer, W. D. & Acott, T., Mar 2012, In : Current Opinion in Ophthalmology. 23, 2, p. 135-143 9 p.

Research output: Contribution to journalArticle

Intraocular Pressure
Glaucoma
Extracellular Matrix
Trabecular Meshwork
rho-Associated Kinases
18 Citations (Scopus)

Inhibition of Hyaluronan Synthesis Reduces Versican and Fibronectin Levels in Trabecular Meshwork Cells

Keller, K., Sun, Y. Y., Vranka, J., Hayashi, L. & Acott, T., Nov 5 2012, In : PLoS One. 7, 11, e48523.

Research output: Contribution to journalArticle

Versicans
Trabecular Meshwork
hyaluronic acid
fibronectins
Hyaluronic Acid
10 Citations (Scopus)

Perturbation of hyaluronan synthesis in the trabecular meshwork and the effects on outflow facility

Keller, K., Sun, Y. Y., Yang, Y. F., Bradley, J. M. & Acott, T., Jul 2012, In : Investigative Ophthalmology and Visual Science. 53, 8, p. 4616-4625 10 p.

Research output: Contribution to journalArticle

Trabecular Meshwork
Hyaluronic Acid
Hymecromone
Swine
Perfusion
45 Citations (Scopus)

Variants in ASB10 are associated with open-angle glaucoma

Pasutto, F., Keller, K., Weisschuh, N., Sticht, H., Samples, J. R., Yang, Y. F., Zenkel, M., Schlötzer-Schrehardt, U., Mardin, C. Y., Frezzotti, P., Edmunds, L. B., Kramer, P. L., Gramer, E., Reis, A., Acott, T. & Wirtz, M., Mar 2012, In : Human Molecular Genetics. 21, 6, p. 1336-1349 14 p., ddr572.

Research output: Contribution to journalArticle

Ankyrin Repeat
Retinal Ganglion Cells
Open Angle Glaucoma
Glaucoma
Suppressor of Cytokine Signaling Proteins
2011
151 Citations (Scopus)

Elastic modulus determination of normal and glaucomatous human trabecular meshwork

Last, J. A., Pan, T., Ding, Y., Reilly, C. M., Keller, K., Acott, T., Fautsch, M. P., Murphy, C. J. & Russell, P., Apr 2011, In : Investigative Ophthalmology and Visual Science. 52, 5, p. 2147-2152 6 p.

Research output: Contribution to journalArticle

Trabecular Meshwork
Elastic Modulus
Intraocular Pressure
Glaucoma
Aqueous Humor
9 Citations (Scopus)

Molecular chaperone function for myocilin

Anderssohn, A. M., Cox, K., O'Malley, K., Dees, S., Hosseini, M., Boren, L., Wagner, A., Bradley, J. M., Kelley, M. & Acott, T., Sep 2011, In : Investigative Ophthalmology and Visual Science. 52, 10, p. 7548-7555 8 p.

Research output: Contribution to journalArticle

Molecular Chaperones
Citrate (si)-Synthase
Hot Temperature
Trabecular Meshwork
Glyceraldehyde-3-Phosphate Dehydrogenases
52 Citations (Scopus)

Segmental versican expression in the trabecular meshwork and involvement in outflow facility

Keller, K., Bradley, J. M., Vranka, J. & Acott, T., Jul 2011, In : Investigative Ophthalmology and Visual Science. 52, 8, p. 5049-5057 9 p.

Research output: Contribution to journalArticle

Versicans
Trabecular Meshwork
Swine
Quantum Dots
Messenger RNA
2009
31 Citations (Scopus)

Differential effects of ADAMTS-1, -4, and -5 in the trabecular meshwork

Keller, K., Bradley, J. M. & Acott, T., Dec 2009, In : Investigative Ophthalmology and Visual Science. 50, 12, p. 5769-5777 9 p.

Research output: Contribution to journalArticle

Trabecular Meshwork
Messenger RNA
Pressure
Perfusion
Thrombospondin 1
116 Citations (Scopus)

Extracellular matrix turnover and outflow resistance

Keller, K., Aga, M., Bradley, J. M., Kelley, M. & Acott, T., Apr 30 2009, In : Experimental Eye Research. 88, 4, p. 676-682 7 p.

Research output: Contribution to journalArticle

Extracellular Matrix
Intraocular Pressure
Trabecular Meshwork
Peptide Hydrolases
Podosomes
45 Citations (Scopus)

Stem cells in the trabecular meshwork: Present and future promises

Kelley, M., Rose, A. Y., Keller, K., Hessle, H., Samples, J. R. & Acott, T., Apr 30 2009, In : Experimental Eye Research. 88, 4, p. 747-751 5 p.

Research output: Contribution to journalArticle

Trabecular Meshwork
Stem Cells
Cell Division
Lasers
Trabeculectomy
2008
48 Citations (Scopus)

Effects of modifiers of glycosaminoglycan biosynthesis on outflow facility in perfusion culture

Keller, K., Bradley, J. M., Kelley, M. & Acott, T., Jun 2008, In : Investigative Ophthalmology and Visual Science. 49, 6, p. 2495-2505 11 p.

Research output: Contribution to journalArticle

Chlorates
Trabecular Meshwork
Glycosaminoglycans
Perfusion
Staining and Labeling
220 Citations (Scopus)

Extracellular matrix in the trabecular meshwork

Acott, T. & Kelley, M., Apr 2008, In : Experimental Eye Research. 86, 4, p. 543-561 19 p.

Research output: Contribution to journalArticle

Trabecular Meshwork
Extracellular Matrix
Intraocular Pressure
Aqueous Humor
Open Angle Glaucoma
43 Citations (Scopus)
Trabecular Meshwork
Extracellular Matrix
Matrix Metalloproteinase 14
Matrix Metalloproteinase 2
Cortactin
2007
57 Citations (Scopus)
Trabecular Meshwork
Alternative Splicing
Collagen Type XII
Extracellular Matrix
Protein Isoforms
14 Citations (Scopus)

Identification of novel alternatively spliced isoforms of RTEF-1 within human ocular vascular endothelial cells and murine retina

Appukuttan, B., McFarland, T. J., Davies, M. H., Atchaneeyasakul, L. O., Zhang, Y., Babra, B., Pan, Y., Rosenbaum, J. J., Acott, T., Powers, M. M. & Stout, J. T., Aug 2007, In : Investigative Ophthalmology and Visual Science. 48, 8, p. 3775-3782 8 p.

Research output: Contribution to journalArticle

Retina
Protein Isoforms
Endothelial Cells
Vascular Endothelial Growth Factor A
Retinal Vessels
14 Citations (Scopus)

p38 MAP kinase pathway and stromelysin regulation in trabecular meshwork cells

Kelley, M., Rose, A., Song, K., Lystrup, B., Samples, J. W. & Acott, T., Jul 2007, In : Investigative Ophthalmology and Visual Science. 48, 7, p. 3126-3137 12 p.

Research output: Contribution to journalArticle

Trabecular Meshwork
Matrix Metalloproteinase 3
MAP Kinase Signaling System
p38 Mitogen-Activated Protein Kinases
Interleukin-1
38 Citations (Scopus)

Retinal pigment epithelium produces matrix metalloproteinases after laser treatment

Flaxel, C., Bradle, J., Acott, T. & Samples, J. R., Jun 2007, In : Retina. 27, 5, p. 629-634 6 p.

Research output: Contribution to journalArticle

Tissue Inhibitor of Metalloproteinases
Retinal Pigment Epithelium
Light Coagulation
Matrix Metalloproteinases
Matrix Metalloproteinase Inhibitors
56 Citations (Scopus)

Synergism of TNF and IL-1 in the induction of matrix metalloproteinase-3 in trabecular meshwork

Kelley, M., Rose, A. Y., Song, K., Chen, Y., Bradley, J. M., Rookhuizen, D. & Acott, T., Jun 2007, In : Investigative Ophthalmology and Visual Science. 48, 6, p. 2634-2643 10 p.

Research output: Contribution to journalArticle

Trabecular Meshwork
Matrix Metalloproteinase 3
Interleukin-1
Matrix Metalloproteinases
Interleukin-1 Receptors
2006
62 Citations (Scopus)

Aqueous humor outflow: What do we know? Where will it lead us?

Fautsch, M. P., Johnson, D. H., Acott, T., Aihara, M., Bhattacharya, S. K., Borrás, T., Camras, C. B., Civan, M. M., Clark, A. F., Crosson, C. E., Crowston, J. G., Epstein, D., Ethier, C. R., Freddo, T. F., Gong, H., Gonzalez, P., John, S. W., Johnson, M., Kaufman, P. L., Knepper, P. A. & 30 others, Lindsey, J. D., Lütjen-Drecoll, E., Peters, D. M., Rao, P. V., Roy, S., Russell, P., Stamer, D., Tamm, E. R., Toris, C. B., Weinreb, R. N., Yue, B., Bornstein, P., Davies, P. F., Geiger, B., Kerjaschki, D., Mitchell, J., Schneeberger, E., Stitt, A., Zawieja, D. C., Bosworth, C., Grunden, J., Kim, E., Kopczynski, C., Krauss, A., Panjwani, N., Paterson, C., Prasanna, G., Rhee, D., Whitlock, A. & WuDunn, D., Oct 2006, In : Investigative Ophthalmology and Visual Science. 47, 10, p. 4181-4187 7 p.

Research output: Contribution to journalArticle

Aqueous Humor
Vacuoles
Terminology
Endothelium
Culture Media
14 Citations (Scopus)

Expanded genome scan in extended families with age-related macular degeneration

Barral, S., Francis, P. J., Schultz, D. W., Schain, M. B., Haynes, C., Majewski, J., Ott, J., Acott, T., Weleber, R. & Klein, M., Dec 2006, In : Investigative Ophthalmology and Visual Science. 47, 12, p. 5453-5459 7 p.

Research output: Contribution to journalArticle

Macular Degeneration
Genome
Pedigree
Geographic Atrophy
Illegitimacy
34 Citations (Scopus)

IL-1 and TNF induction of matrix metalloproteinase-3 by c-Jun N-terminal kinase in trabecular meshwork

Hosseini, M., Rose, A. Y., Song, K., Bohan, C., Alexander, J. P., Kelley, M. & Acott, T., Apr 2006, In : Investigative Ophthalmology and Visual Science. 47, 4, p. 1469-1476 8 p.

Research output: Contribution to journalArticle

Trabecular Meshwork
Matrix Metalloproteinase 3
JNK Mitogen-Activated Protein Kinases
Matrix Metalloproteinases
Interleukin-1
2005
94 Citations (Scopus)

Changes in gene expression by trabecular meshwork cells in response to mechanical stretching

Vittal, V., Rose, A., Gregory, K. E., Kelley, M. & Acott, T., 2005, In : Investigative Ophthalmology and Visual Science. 46, 8, p. 2857-2868 12 p.

Research output: Contribution to journalArticle

Trabecular Meshwork
Gene Expression
Genes
Aqueous Humor
Extracellular Matrix Proteins
46 Citations (Scopus)

Genetic and phenotypic heterogeneity in pattern dystrophy

Francis, P. J., Schultz, D. W., Gregory, A., Schain, M. B., Barra, R., Majewski, J., Ott, J., Acott, T., Weleber, R. & Klein, M., Sep 2005, In : British Journal of Ophthalmology. 89, 9, p. 1115-1119 5 p.

Research output: Contribution to journalArticle

Genetic Heterogeneity
Peripherins
Geographic Atrophy
Mutation
Electrophysiology
29 Citations (Scopus)

HEMICENTIN-1 (FIBULIN-6) and the 1q31 AMD locus in the context of complex disease: Review and perspective

Schultz, D. W., Weleber, R., Lawrence, G., Barral, S., Majewski, J., Acott, T. & Klein, M., Jun 2005, In : Ophthalmic Genetics. 26, 2, p. 101-105 5 p.

Research output: Contribution to journalArticle

Macular Degeneration
Western World
Mutation
Gene Frequency
Type 2 Diabetes Mellitus
2003
152 Citations (Scopus)

Age-related macular degeneration - A genome scan in extended families

Majewski, J., Schultz, D. W., Weleber, R., Schain, M. B., Edwards, A. O., Matise, T. C., Acott, T., Ott, J. & Klein, M., Sep 1 2003, In : American Journal of Human Genetics. 73, 3, p. 540-550 11 p.

Research output: Contribution to journalArticle

Macular Degeneration
Genome
Pedigree
Nuclear Family
Geographic Atrophy
150 Citations (Scopus)

Analysis of the ARMD1 locus: Evidence that a mutation in HEMICENTIN-1 is associated with age-related macular degeneration in a large family

Schultz, D. W., Klein, M., Humpert, A. J., Luzier, C. W., Persun, V., Schain, M., Mahan, A., Runckel, C., Cassera, M., Vittal, V., Doyle, T. M., Martin, T., Weleber, R., Francis, P. J. & Acott, T., Dec 15 2003, In : Human Molecular Genetics. 12, 24, p. 3315-3323 9 p.

Research output: Contribution to journalArticle

Macular Degeneration
Mutation
Glutamine
Haplotypes
Genes
50 Citations (Scopus)

Involvement of the Erk-MAP kinase pathway in TNFα regulation of trabecular matrix metalloproteinases and TIMPs

Alexander, J. P. & Acott, T., Jan 1 2003, In : Investigative Ophthalmology and Visual Science. 44, 1, p. 164-169 6 p.

Research output: Contribution to journalArticle

Extracellular Signal-Regulated MAP Kinases
Mitogen-Activated Protein Kinases
Matrix Metalloproteinases
Trabecular Meshwork
Protein Kinase C
57 Citations (Scopus)

Lack of an association of apolipoprotein E gene polymorphisms with familial age-related macular degeneration

Schultz, D. W., Klein, M., Humpert, A., Majewski, J., Schain, M., Weleber, R., Ott, J. & Acott, T., May 1 2003, In : Archives of Ophthalmology. 121, 5, p. 679-683 5 p.

Research output: Contribution to journalArticle

Macular Degeneration
Apolipoproteins E
Genes
Alleles
Apolipoprotein E2
72 Citations (Scopus)

Signaling Pathways Used in Trabecular Matrix Metalloproteinase Response to Mechanical Stretch

Bradley, J. M. B., Kelley, M., Rose, A. & Acott, T., Dec 2003, In : Investigative Ophthalmology and Visual Science. 44, 12, p. 5174-5181 8 p.

Research output: Contribution to journalArticle

Matrix Metalloproteinase 2
Matrix Metalloproteinase 14
Matrix Metalloproteinases
Trabecular Meshwork
Sirolimus
2002
26 Citations (Scopus)

Expression profile and genome location of cDNA clones from an infant human trabecular meshwork cell library

Wirtz, M., Samples, J. R., Xu, H., Severson, T. & Acott, T., Dec 1 2002, In : Investigative Ophthalmology and Visual Science. 43, 12, p. 3698-3704 7 p.

Research output: Contribution to journalArticle

Trabecular Meshwork
Expressed Sequence Tags
Complementary DNA
Clone Cells
Genome
2001
127 Citations (Scopus)

Effects of mechanical stretching on trabecular matrix metalloproteinases

Bradley, J. M. B., Kelley, M., Zhu, X., Anderssohn, A. M., Alexander, J. P. & Acott, T., 2001, In : Investigative Ophthalmology and Visual Science. 42, 7, p. 1505-1513 9 p.

Research output: Contribution to journalArticle

Matrix Metalloproteinase 2
Matrix Metalloproteinases
Intraocular Pressure
Trabecular Meshwork
Extracellular Matrix
47 Citations (Scopus)

Involvement of protein kinase C in TNFα regulation of trabecular matrix metalloproteinases and TIMPs

Alexander, J. P. & Acott, T., 2001, In : Investigative Ophthalmology and Visual Science. 42, 12, p. 2831-2838 8 p.

Research output: Contribution to journalArticle

Matrix Metalloproteinases
Protein Kinase C
Protein Isoforms
Trabecular Meshwork
Signal Transduction
2000
28 Citations (Scopus)
Collagen Type I
Glaucoma
Trabecular Meshwork
Proteins
Expressed Sequence Tags
123 Citations (Scopus)

Mediation of laser trabeculoplasty-induced matrix metalloproteinase expression by IL-1β and TNFα

Bradley, J. M. B., Anderssohn, A. M., Colvis, C. M., Parshley, D. E., Zhu, X., Ruddat, M. S., Samples, J. R. & Acott, T., 2000, In : Investigative Ophthalmology and Visual Science. 41, 2, p. 422-430 9 p.

Research output: Contribution to journalArticle

Trabeculectomy
Organ Culture Techniques
Matrix Metalloproteinases
Interleukin-1
Matrix Metalloproteinase 3
1999
44 Citations (Scopus)

Autosomal dominant Stargardt-like macular dystrophy: I. Clinical characterization, longitudinal follow-up, and evidence for a common ancestry in families linked to chromosome 6q14

Edwards, A. O., Miedziak, A., Vrabec, T., Verhoeven, J., Acott, T., Weleber, R. & Donoso, L. A., Apr 1999, In : American Journal of Ophthalmology. 127, 4, p. 426-435 10 p.

Research output: Contribution to journalArticle

Chromosomes
Phenotype
Geographic Atrophy
Founder Effect
Pallor