Ted Acott

Research Professor

  • 6105 Citations
  • 47 h-Index
1978 …2019

Research output per year

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Research Output

  • 6105 Citations
  • 47 h-Index
  • 89 Article
  • 9 Review article
  • 1 Letter
  • 1 Short survey
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Article
2019

GPR158 in the visual system: Homeostatic role in regulation of intraocular pressure

Itakura, T., Webster, A., Chintala, S. K., Wang, Y., Gonzalez, J. M., Tan, J. C., Vranka, J. A., Acott, T., Craft, C. M., Sibug Saber, M. E., Jeong, S., Stamer, W. D., Martemyanov, K. A. & Fini, M. E., May 2019, In : Journal of Ocular Pharmacology and Therapeutics. 35, 4, p. 203-215 13 p.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations
2018

Biomechanical rigidity and quantitative proteomics analysis of segmental regions of the trabecular meshwork at physiologic and elevated pressures

Vranka, J. A., Staverosky, J. A., Reddy, A. P., Wilmarth, P. A., David, L. L., Acott, T. S., Russell, P. & Raghunathan, V. K., Jan 2018, In : Investigative Ophthalmology and Visual Science. 59, 1, p. 246-259 14 p.

Research output: Contribution to journalArticle

7 Scopus citations

Glaucomatous cell derived matrices differentially modulate non-glaucomatous trabecular meshwork cellular behavior

Raghunathan, V. K., Benoit, J., Kasetti, R., Zode, G., Salemi, M., Phinney, B. S., Keller, K., Staverosky, J., Murphy, C. J., Acott, T. & Vranka, J., Jan 1 2018, (Accepted/In press) In : Acta Biomaterialia.

Research output: Contribution to journalArticle

10 Scopus citations
2017

Estimating human trabecular meshwork stiffness by numerical modeling and advanced OCT imaging

Wang, K., Johnstone, M. A., Xin, C., Song, S., Padilla, S., Vranka, J., Acott, T., Zhou, K., Schwaner, S. A., Wang, R. K., Sulchek, T. & Ethier, C. R., Sep 1 2017, In : Investigative Ophthalmology and Visual Science. 58, 11, p. 4809-4817 9 p.

Research output: Contribution to journalArticle

9 Scopus citations

Tunneling nanotubes are novel cellular structures that communicate signals between trabecular meshwork cells

Keller, K. E., Bradley, J. M., Sun, Y. Y., Yang, Y. F. & Acott, T. S., Oct 2017, In : Investigative Ophthalmology and Visual Science. 58, 12, p. 5298-5307 10 p.

Research output: Contribution to journalArticle

12 Scopus citations
2016
11 Scopus citations

Pressure-induced expression changes in segmental flow regions of the human trabecular meshwork

Vranka, J. & Acott, T., Mar 15 2016, (Accepted/In press) In : Experimental Eye Research.

Research output: Contribution to journalArticle

13 Scopus citations
2015

Induced pluripotent stem cells restore function in a human cell loss model of open-angle glaucoma

Abu-Hassan, D. W., Li, X., Ryan, E. I., Acott, T. S. & Kelley, M. J., Mar 1 2015, In : Stem Cells. 33, 3, p. 751-761 11 p.

Research output: Contribution to journalArticle

49 Scopus citations
41 Scopus citations
2014
34 Scopus citations

Interleukin-20 receptor expression in the trabecular meshwork and its implication in glaucoma

Keller, K. E., Yang, Y. F., Sun, Y. Y., Sykes, R., Gaudette, N. D., Samples, J. R., Acott, T. S. & Wirtz, M. K., Mar 1 2014, In : Journal of Ocular Pharmacology and Therapeutics. 30, 2-3, p. 267-276 10 p.

Research output: Contribution to journalArticle

14 Scopus citations
2013
17 Scopus citations

The effects of tenascin C knockdown on trabecular meshwork outflow resistance

Keller, K. E., Vranka, J. A., Haddadin, R. I., Kang, M. H., Oh, D. J., Rhee, D. J., Yang, Y. F., Sun, Y. Y., Kelley, M. J. & Acott, T. S., Aug 28 2013, In : Investigative Ophthalmology and Visual Science. 54, 8, p. 5613-5623 11 p.

Research output: Contribution to journalArticle

14 Scopus citations
2012

Inhibition of Hyaluronan Synthesis Reduces Versican and Fibronectin Levels in Trabecular Meshwork Cells

Keller, K. E., Sun, Y. Y., Vranka, J. A., Hayashi, L. & Acott, T. S., Nov 5 2012, In : PloS one. 7, 11, e48523.

Research output: Contribution to journalArticle

20 Scopus citations

Perturbation of hyaluronan synthesis in the trabecular meshwork and the effects on outflow facility

Keller, K. E., Sun, Y. Y., Yang, Y. F., Bradley, J. M. & Acott, T. S., Jul 1 2012, In : Investigative Ophthalmology and Visual Science. 53, 8, p. 4616-4625 10 p.

Research output: Contribution to journalArticle

11 Scopus citations

Variants in ASB10 are associated with open-angle glaucoma

Pasutto, F., Keller, K. E., Weisschuh, N., Sticht, H., Samples, J. R., Yang, Y. F., Zenkel, M., Schlötzer-Schrehardt, U., Mardin, C. Y., Frezzotti, P., Edmunds, B., Kramer, P. L., Gramer, E., Reis, A., Acott, T. S. & Wirtz, M. K., Mar 2012, In : Human molecular genetics. 21, 6, p. 1336-1349 14 p., ddr572.

Research output: Contribution to journalArticle

51 Scopus citations
2011

Elastic modulus determination of normal and glaucomatous human trabecular meshwork

Last, J. A., Pan, T., Ding, Y., Reilly, C. M., Keller, K., Acott, T. S., Fautsch, M. P., Murphy, C. J. & Russell, P., Apr 2011, In : Investigative Ophthalmology and Visual Science. 52, 5, p. 2147-2152 6 p.

Research output: Contribution to journalArticle

166 Scopus citations

Molecular chaperone function for myocilin

Anderssohn, A. M., Cox, K., O'Malley, K., Dees, S., Hosseini, M., Boren, L., Wagner, A., Bradley, J. M., Kelley, M. J. & Acott, T. S., Sep 1 2011, In : Investigative Ophthalmology and Visual Science. 52, 10, p. 7548-7555 8 p.

Research output: Contribution to journalArticle

9 Scopus citations
64 Scopus citations
2009

Differential effects of ADAMTS-1, -4, and -5 in the trabecular meshwork

Keller, K. E., Bradley, J. M. & Acott, T. S., Dec 2009, In : Investigative Ophthalmology and Visual Science. 50, 12, p. 5769-5777 9 p.

Research output: Contribution to journalArticle

36 Scopus citations
2008
53 Scopus citations
46 Scopus citations
2007
64 Scopus citations

Identification of novel alternatively spliced isoforms of RTEF-1 within human ocular vascular endothelial cells and murine retina

Appukuttan, B., McFarland, T. J., Davies, M. H., Atchaneeyasakul, L. O., Zhang, Y., Babra, B., Pan, Y., Rosenbaum, J. T., Acott, T., Powers, M. R. & Stout, J. T., Aug 1 2007, In : Investigative Ophthalmology and Visual Science. 48, 8, p. 3775-3782 8 p.

Research output: Contribution to journalArticle

14 Scopus citations

p38 MAP kinase pathway and stromelysin regulation in trabecular meshwork cells

Kelley, M. J., Rose, A., Song, K., Lystrup, B., Samples, J. W. & Acott, T. S., Jul 1 2007, In : Investigative Ophthalmology and Visual Science. 48, 7, p. 3126-3137 12 p.

Research output: Contribution to journalArticle

14 Scopus citations

Retinal pigment epithelium produces matrix metalloproteinases after laser treatment

Flaxel, C., Bradle, J., Acott, T. & Samples, J. R., Jun 1 2007, In : Retina. 27, 5, p. 629-634 6 p.

Research output: Contribution to journalArticle

42 Scopus citations

Synergism of TNF and IL-1 in the induction of matrix metalloproteinase-3 in trabecular meshwork

Kelley, M. J., Rose, A. Y., Song, K., Chen, Y., Bradley, J. M., Rookhuizen, D. & Acott, T. S., Jun 1 2007, In : Investigative Ophthalmology and Visual Science. 48, 6, p. 2634-2643 10 p.

Research output: Contribution to journalArticle

56 Scopus citations
2006

Aqueous humor outflow: What do we know? Where will it lead us?

Fautsch, M. P., Johnson, D. H., Acott, T. S., Aihara, M., Bhattacharya, S. K., Borrás, T., Camras, C. B., Civan, M. M., Clark, A. F., Crosson, C. E., Crowston, J. G., Epstein, D., Ethier, C. R., Freddo, T. F., Gong, H., Gonzalez, P., John, S. W., Johnson, M., Kaufman, P. L., Knepper, P. A. & 30 others, Lindsey, J. D., Lütjen-Drecoll, E., Peters, D. M., Rao, P. V., Roy, S., Russell, P., Stamer, D., Tamm, E. R., Toris, C. B., Weinreb, R. N., Yue, B., Bornstein, P., Davies, P. F., Geiger, B., Kerjaschki, D., Mitchell, J., Schneeberger, E., Stitt, A., Zawieja, D. C., Bosworth, C., Grunden, J., Kim, E., Kopczynski, C., Krauss, A., Panjwani, N., Paterson, C., Prasanna, G., Rhee, D., Whitlock, A. & WuDunn, D., Oct 2006, In : Investigative Ophthalmology and Visual Science. 47, 10, p. 4181-4187 7 p.

Research output: Contribution to journalArticle

71 Scopus citations

Expanded genome scan in extended families with age-related macular degeneration

Barral, S., Francis, P. J., Schultz, D. W., Schain, M. B., Haynes, C., Majewski, J., Ott, J., Acott, T., Weleber, R. G. & Klein, M. L., Dec 1 2006, In : Investigative Ophthalmology and Visual Science. 47, 12, p. 5453-5459 7 p.

Research output: Contribution to journalArticle

15 Scopus citations

IL-1 and TNF induction of matrix metalloproteinase-3 by c-Jun N-terminal kinase in trabecular meshwork

Hosseini, M., Rose, A. Y., Song, K., Bohan, C., Alexander, J. P., Kelley, M. J. & Acott, T. S., Apr 1 2006, In : Investigative Ophthalmology and Visual Science. 47, 4, p. 1469-1476 8 p.

Research output: Contribution to journalArticle

34 Scopus citations
2005

Changes in gene expression by trabecular meshwork cells in response to mechanical stretching

Vittal, V., Rose, A., Gregory, K. E., Kelley, M. J. & Acott, T. S., Dec 1 2005, In : Investigative Ophthalmology and Visual Science. 46, 8, p. 2857-2868 12 p.

Research output: Contribution to journalArticle

100 Scopus citations

Genetic and phenotypic heterogeneity in pattern dystrophy

Francis, P. J., Schultz, D. W., Gregory, A. M., Schain, M. B., Barra, R., Majewski, J., Ott, J., Acott, T., Weleber, R. G. & Klein, M. L., Sep 2005, In : British Journal of Ophthalmology. 89, 9, p. 1115-1119 5 p.

Research output: Contribution to journalArticle

49 Scopus citations
2003

Age-related macular degeneration - A genome scan in extended families

Majewski, J., Schultz, D. W., Weleber, R. G., Schain, M. B., Edwards, A. O., Matise, T. C., Acott, T. S., Ott, J. & Klein, M. L., Sep 1 2003, In : American Journal of Human Genetics. 73, 3, p. 540-550 11 p.

Research output: Contribution to journalArticle

153 Scopus citations

Analysis of the ARMD1 locus: Evidence that a mutation in HEMICENTIN-1 is associated with age-related macular degeneration in a large family

Schultz, D. W., Klein, M. L., Humpert, A. J., Luzier, C. W., Persun, V., Schain, M., Mahan, A., Runckel, C., Cassera, M., Vittal, V., Doyle, T. M., Martin, T. M., Weleber, R. G., Francis, P. J. & Acott, T. S., Dec 15 2003, In : Human molecular genetics. 12, 24, p. 3315-3323 9 p.

Research output: Contribution to journalArticle

155 Scopus citations
53 Scopus citations

Lack of an association of apolipoprotein E gene polymorphisms with familial age-related macular degeneration

Schultz, D. W., Klein, M. L., Humpert, A., Majewski, J., Schain, M., Weleber, R. G., Ott, J. & Acott, T. S., May 1 2003, In : Archives of ophthalmology. 121, 5, p. 679-683 5 p.

Research output: Contribution to journalArticle

58 Scopus citations

Signaling Pathways Used in Trabecular Matrix Metalloproteinase Response to Mechanical Stretch

Bradley, J. M. B., Kelley, M. J., Rose, A. & Acott, T. S., Dec 1 2003, In : Investigative Ophthalmology and Visual Science. 44, 12, p. 5174-5181 8 p.

Research output: Contribution to journalArticle

75 Scopus citations
2002

Expression profile and genome location of cDNA clones from an infant human trabecular meshwork cell library

Wirtz, M. K., Samples, J. R., Xu, H., Severson, T. & Acott, T. S., Dec 1 2002, In : Investigative Ophthalmology and Visual Science. 43, 12, p. 3698-3704 7 p.

Research output: Contribution to journalArticle

27 Scopus citations
2001

Effects of mechanical stretching on trabecular matrix metalloproteinases

Bradley, J. M. B., Kelley, M. J., Zhu, X., Anderssohn, A. M., Alexander, J. P. & Acott, T. S., Jun 21 2001, In : Investigative Ophthalmology and Visual Science. 42, 7, p. 1505-1513 9 p.

Research output: Contribution to journalArticle

142 Scopus citations

Involvement of protein kinase C in TNFα regulation of trabecular matrix metalloproteinases and TIMPs

Alexander, J. P. & Acott, T. S., Nov 20 2001, In : Investigative Ophthalmology and Visual Science. 42, 12, p. 2831-2838 8 p.

Research output: Contribution to journalArticle

47 Scopus citations
2000
28 Scopus citations

Mediation of laser trabeculoplasty-induced matrix metalloproteinase expression by IL-1β and TNFα

Bradley, J. M. B., Anderssohn, A. M., Colvis, C. M., Parshley, D. E., Zhu, X. H., Ruddat, M. S., Samples, J. R. & Acott, T. S., Feb 15 2000, In : Investigative Ophthalmology and Visual Science. 41, 2, p. 422-430 9 p.

Research output: Contribution to journalArticle

130 Scopus citations
1999

Autosomal dominant Stargardt-like macular dystrophy: I. Clinical characterization, longitudinal follow-up, and evidence for a common ancestry in families linked to chromosome 6q14

Edwards, A. O., Miedziak, A., Vrabec, T., Verhoeven, J., Acott, T. S., Weleber, R. G. & Donoso, L. A., Apr 1 1999, In : American journal of ophthalmology. 127, 4, p. 426-435 10 p.

Research output: Contribution to journalArticle

44 Scopus citations

GLC1F, a new primary open-angle glaucoma locus, maps to 7q35-q36

Wirtz, M. K., Samples, J. R., Rust, K., Lie, J., Nordling, L. A., Schilling, K., Acott, T. S. & Kramer, P. L., Feb 1999, In : Archives of ophthalmology. 117, 2, p. 237-241 5 p.

Research output: Contribution to journalArticle

Open Access
161 Scopus citations
1998

Age-related macular degeneration: Clinical features in a large family and linkage to chromosome 1q

Klein, M. L., Schultz, D. W., Edwards, A., Matise, T. C., Rust, K., Berselli, C. B., Trzupek, K., Weleber, R. G., Ott, J., Wirtz, M. K. & Acott, T. S., Aug 1998, In : Archives of ophthalmology. 116, 8, p. 1082-1088 7 p.

Research output: Contribution to journalArticle

Open Access
195 Scopus citations

Effect of matrix metalloproteinases activity on outflow in perfused human organ culture

Bradley, J. M. B., Vranka, J., Colvis, C. M., Conger, D. M., Alexander, J. P., Fisk, A. S., Samples, J. R. & Acott, T. S., Dec 1 1998, In : Investigative Ophthalmology and Visual Science. 39, 13, p. 2649-2658 10 p.

Research output: Contribution to journalArticle

270 Scopus citations

Growth factor and cytokine modulation of trabecular meshwork matrix metalloproteinase and TIMP expression

Alexander, J. P., Samples, J. R. & Acott, T. S., Apr 8 1998, In : Current Eye Research. 17, 3, p. 276-285 10 p.

Research output: Contribution to journalArticle

101 Scopus citations

Insulin-like growth factor binding protein-5 expression by human trabecular meshwork

Wirtz, M. K., Xu, H., Rust, K., Alexander, J. P. & Acott, T. S., Jan 1 1998, In : Investigative Ophthalmology and Visual Science. 39, 1, p. 45-53 9 p.

Research output: Contribution to journalArticle

28 Scopus citations

Malattia leventinese: Refinement of the genetic locus and phenotypic variability in autosomal dominant macular drusen

Edwards, A. O., Klein, M. L., Berselli, C. B., Hejtmancik, J. F., Rust, K., Wirtz, M. K., Weleber, R. G. & Acott, T. S., Sep 1 1998, In : American journal of ophthalmology. 126, 3, p. 417-424 8 p.

Research output: Contribution to journalArticle

26 Scopus citations
1997

Discrete expression and distribution pattern of TIMP-3 in the human retina and choroid

Vranka, J. A., Johnson, E., Zhu, X., Shepardson, A., Alexander, J. P., Bradley, J. M. B., Wirtz, M. K., Weleber, R. G., Klein, M. L. & Acott, T. S., Mar 17 1997, In : Current Eye Research. 16, 2, p. 102-110 9 p.

Research output: Contribution to journalArticle

57 Scopus citations