Patrizia Caposio

Assistant Scientist

  • 908 Citations
  • 20 h-Index
20012019
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Research Output 2001 2019

  • 908 Citations
  • 20 h-Index
  • 37 Article
  • 1 Editorial
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35 Citations (Scopus)

Activation of the virus-induced IKK/NF-κB signalling axis is critical for the replication of human cytomegalovirus in quiescent cells

Caposio, P., Luganini, A., Hahn, G., Landolfo, S. & Gribaudo, G., Aug 2007, In : Cellular Microbiology. 9, 8, p. 2040-2054 15 p.

Research output: Contribution to journalArticle

Virus Activation
Cytomegalovirus
Viruses
Chemical activation
Endothelial cells
35 Citations (Scopus)

A cytomegalovirus-based vaccine expressing a single tumor-specific CD8 + T-cell epitope delays tumor growth in a murine model of prostate cancer

Klyushnenkova, E. N., Kouiavskaia, D. V., Parkins, C. J., Caposio, P., Botto, S., Alexander, R. B. & Jarvis, M. A., Jun 2012, In : Journal of Immunotherapy. 35, 5, p. 390-399 10 p.

Research output: Contribution to journalArticle

Cytomegalovirus Vaccines
T-Lymphocyte Epitopes
Prostate-Specific Antigen
Prostatic Neoplasms
Growth
30 Citations (Scopus)

A cytomegalovirus-based vaccine provides long-lasting protection against lethal Ebola virus challenge after a single dose

Tsuda, Y., Parkins, C. J., Caposio, P., Feldmann, F., Botto, S., Ball, S., Messaoudi, I., Cicin-Sain, L., Feldmann, H. & Jarvis, M. A., 2015, In : Vaccine. 33, 19, p. 2261-2266 6 p.

Research output: Contribution to journalArticle

Zaire Ebola virus
Cytomegalovirus Vaccines
Ebolavirus
Cytomegalovirus
vaccines
75 Citations (Scopus)

A novel human cytomegalovirus locus modulates cell type-specific outcomes of infection

Umashankar, M., Petrucelli, A., Cicchini, L., Caposio, P., Kreklywich, C. N., Rak, M., Bughio, F., Goldman, D., Hamlin, K. L., Nelson, J., Fleming, W., Streblow, D. & Goodrum, F., Dec 2011, In : PLoS Pathogens. 7, 12, e1002444.

Research output: Contribution to journalArticle

Hematopoietic Stem Cells
Cytomegalovirus
Viruses
Fibroblasts
Infection
50 Citations (Scopus)

A novel role of the interferon-inducible protein IFI16 as inducer of proinflammatory molecules in endothelial cells

Caposio, P., Gugliesi, F., Zannetti, C., Sponza, S., Mondini, M., Medico, E., Hiscott, J., Young, H. A., Gribaudo, G., Gariglio, M. & Landolfo, S., Nov 16 2007, In : Journal of Biological Chemistry. 282, 46, p. 33515-33529 15 p.

Research output: Contribution to journalArticle

Endothelial cells
Interferons
Endothelial Cells
Genes
Molecules
63 Citations (Scopus)

A replicating cytomegalovirus-based vaccine encoding a single Ebola virus nucleoprotein CTL epitope confers protection against Ebola virus

Tsuda, Y., Caposio, P., Parkins, C. J., Botto, S., Messaoudi, I., Cicin-Sain, L., Feldmann, H. & Jarvis, M. A., Aug 2011, In : PLoS Neglected Tropical Diseases. 5, 8, e1275.

Research output: Contribution to journalArticle

Cytomegalovirus Vaccines
Ebolavirus
Nucleoproteins
Epitopes
Democratic Republic of the Congo
15 Citations (Scopus)

A single-dose cytomegalovirus-based vaccine encoding tetanus toxin fragment C induces sustained levels of protective tetanus toxin antibodies in mice

Tierney, R., Nakai, T., Parkins, C. J., Caposio, P., Fairweather, N. F., Sesardic, D. & Jarvis, M. A., Apr 26 2012, In : Vaccine. 30, 20, p. 3047-3052 6 p.

Research output: Contribution to journalArticle

Cytomegalovirus Vaccines
Tetanus Toxin
Cytomegalovirus
tetanus
Tetanus
4 Citations (Scopus)

Cloning, assembly, and modification of the primary human cytomegalovirus isolate Toledo by yeast-based transformation-associated recombination

Vashee, S., Stockwell, T. B., Alperovich, N., Denisova, E. A., Gibson, D. G., Cady, K. C., Miller, K., Kannan, K., Malouli, D., Crawford, L. B., Voorhies, A. A., Bruening, E., Caposio, P. & Frueh, K., Sep 1 2017, In : mSphere. 2, 5, e00331-17.

Research output: Contribution to journalArticle

Cytomegalovirus
Genetic Recombination
Organism Cloning
Yeasts
Genome
28 Citations (Scopus)

Cloning and characterization of two catechol 1,2-dioxygenase genes from Acinetobacter radioresistens S13

Caposio, P., Pessione, E., Giuffrida, G., Conti, A., Landolfo, S., Giunta, C. & Gribaudo, G., 2002, In : Research in Microbiology. 153, 2, p. 69-74 6 p.

Research output: Contribution to journalArticle

Catechol 1,2-Dioxygenase
5-chloro-3-tert-butyl-2'-chloro-4'-nitrosalicylanilide
Acinetobacter
Benzoates
Organism Cloning
20 Citations (Scopus)

Complex interplay of the UL136 isoforms balances cytomegalovirus replication and Latency

Caviness, K., Bughio, F., Crawford, L. B., Streblow, D., Nelson, J., Caposio, P. & Goodrum, F., Mar 1 2016, In : mBio. 7, 2, e01986-15.

Research output: Contribution to journalArticle

Cytomegalovirus
Protein Isoforms
Herpesviridae
Cytomegalovirus Infections
Virus Replication
29 Citations (Scopus)

Debridement and local application of tetracycline-loaded fibres in the management of persistent periodontitis: Results after 12 months

Aimetti, M., Romano, F., Torta, I., Cirillo, D., Caposio, P. & Romagnoli, R., Mar 2004, In : Journal of Clinical Periodontology. 31, 3, p. 166-172 7 p.

Research output: Contribution to journalArticle

Root Planing
Periodontitis
Debridement
Tetracycline
Treponema denticola
22 Citations (Scopus)

Evidence that the Human Cytomegalovirus 46-kDa UL72 protein is not an active dUTPase but a late protein dispensable for replication in fibroblasts

Caposio, P., Riera, L., Hahn, G., Landolfo, S. & Gribaudo, G., Aug 1 2004, In : Virology. 325, 2, p. 264-276 13 p.

Research output: Contribution to journalArticle

Cytomegalovirus
Fibroblasts
Genes
Proteins
Herpesviridae
19 Citations (Scopus)

Fine-tuning of catalytic properties of catechol 1,2-dioxygenase by active site tailoring

Caglio, R., Valetti, F., Caposio, P., Gribaudo, G., Pessione, E. & Giunta, C., Apr 17 2009, In : ChemBioChem. 10, 6, p. 1015-1024 10 p.

Research output: Contribution to journalArticle

Catechol 1,2-Dioxygenase
Catalytic Domain
Tuning
Enzymes
Protein Engineering
21 Citations (Scopus)

Human cytomegalovirus-encoded pUL7 is a novel CEACAM1-like molecule responsible for promotion of angiogenesis

Macmaniman, J. D., Meuser, A., Botto, S., Smith, P. P., Liu, F., Jarvis, M. A., Nelson, J. & Caposio, P., Sep 26 2014, In : mBio. 5, 6, e02035-14.

Research output: Contribution to journalArticle

Carcinoembryonic Antigen
Cell Adhesion Molecules
Cytomegalovirus
Interleukin-6
Angiogenesis Inducing Agents

Human cytomegalovirus-encoded pUL7 is a novel CEACAM1-like molecule responsible for promotion of angiogenesis

MacManiman, J. D., Meuser, A., Botto, S., Smith, P. P., Liu, F., Jarvis, M. A., Nelson, J. A. & Caposio, P., 2014, In : mBio. 5, 6, p. e02035

Research output: Contribution to journalArticle

Carcinoembryonic Antigen
Cell Adhesion Molecules
Cytomegalovirus
Cytomegalovirus Infections
Interleukin-6
10 Citations (Scopus)

Human cytomegalovirus encodes a novel FLT3 receptor ligand necessary for hematopoietic cell differentiation and viral reactivation

Crawford, L. B., Kim, J. H., Collins-McMillen, D., Lee, B. J., Landais, I., Held, C., Nelson, J., Yurochko, A. D. & Caposio, P., Mar 1 2018, In : mBio. 9, 2, e00682-18.

Research output: Contribution to journalArticle

Hematopoietic Stem Cells
Cytomegalovirus
Cell Differentiation
Ligands
Receptor Protein-Tyrosine Kinases
14 Citations (Scopus)

Human cytomegalovirus induces cellular and humoral virus-specific immune responses in humanized BLT mice

Crawford, L. B., Tempel, R., Streblow, D., Kreklywich, C., Smith, P., Picker, L., Nelson, J. & Caposio, P., Dec 1 2017, In : Scientific Reports. 7, 1, 937.

Research output: Contribution to journalArticle

Cytomegalovirus
Viruses
Virus Latency
Thymus Gland
Bone Marrow
28 Citations (Scopus)

Human cytomegalovirus infection induces cellular thymidylate synthase gene expression in quiescent fibroblasts

Gribaudo, G., Riera, L., Rudge, T. L., Caposio, P., Johnson, L. F. & Landolfo, S., Dec 1 2002, In : Journal of General Virology. 83, 12, p. 2983-2993 11 p.

Research output: Contribution to journalArticle

Thymidylate Synthase
Cytomegalovirus Infections
Fibroblasts
Gene Expression
Cytomegalovirus
5 Citations (Scopus)

Human cytomegalovirus requires cellular deoxycytidylate deaminase for replication in quiescent cells

Gribaudo, G., Riera, L., Caposio, P., Maley, F. & Landolfo, S., Jun 1 2003, In : Journal of General Virology. 84, 6, p. 1437-1441 5 p.

Research output: Contribution to journalArticle

DCMP Deaminase
Cytomegalovirus
pyrimidin-2-one beta-ribofuranoside
Thymidylate Synthase
Deoxyuridine
33 Citations (Scopus)

Human Cytomegalovirus Stimulates Cellular IKK2 Activity and Requires the Enzyme for Productive Replication

Caposio, P., Dreano, M., Garotta, G., Gribaudo, G. & Landolfo, S., Mar 2004, In : Journal of Virology. 78, 6, p. 3190-3195 6 p.

Research output: Contribution to journalArticle

Human herpesvirus 5
Cytomegalovirus
Enzymes
enzymes
IKappaB kinase
1 Citation (Scopus)

Human Cytomegalovirus US28 Ligand Binding Activity Is Required for Latency in CD34+ Hematopoietic Progenitor Cells and Humanized NSG Mice

Crawford, L. B., Caposio, P., Kreklywich, C., Pham, A. H., Hancock, M., Jones, T. A., Smith, P. P., Yurochko, A. D., Nelson, J. A. & Streblow, D., Aug 20 2019, In : mBio. 10, 4

Research output: Contribution to journalArticle

Open Access
Hematopoietic Stem Cells
Cytomegalovirus
Ligands
Virus Latency
Viruses
20 Citations (Scopus)

Humanized mouse models of human cytomegalovirus infection

Crawford, L. B., Streblow, D., Hakki, M., Nelson, J. & Caposio, P., Jun 29 2015, In : Current Opinion in Virology. 13, p. 86-92 7 p.

Research output: Contribution to journalArticle

Cytomegalovirus Infections
Cytomegalovirus
Herpesviridae
Lymphocytes
Viruses
65 Citations (Scopus)

IL-6 in human cytomegalovirus secretome promotes angiogenesis and survival of endothelial cells through the stimulation of survivin

Botto, S., Streblow, D., De Filippis, V., White, L., Kreklywich, C. N., Smith, P. P. & Caposio, P., Jan 6 2011, In : Blood. 117, 1, p. 352-361 10 p.

Research output: Contribution to journalArticle

Endothelial cells
Cytomegalovirus
Interleukin-6
Endothelial Cells
Effector Caspases
40 Citations (Scopus)

Imbalance between activin A and follistatin drives postburn hypertrophic scar formation in human skin

Fumagalli, M., Musso, T., Vermi, W., Scutera, S., Daniele, R., Alotto, D., Cambieri, I., Ostorero, A., Gentili, F., Caposio, P., Zucca, M., Sozzani, S., Stella, M. & Castagnoli, C., Jul 2007, In : Experimental Dermatology. 16, 7, p. 600-610 11 p.

Research output: Contribution to journalArticle

Follistatin
Hypertrophic Cicatrix
Activins
Fibroblasts
Skin
5 Citations (Scopus)

Molecular approaches to the identification and treatment monitoring of periodontal pathogens

Caposio, P., Torta, I., Romano, F., Aimetti, M., Romagnoli, R., Marchiaro, G. & Cirillo, D. M., Jan 2003, In : New Microbiologica. 26, 1, p. 121-124 4 p.

Research output: Contribution to journalArticle

Periodontal Pocket
Polymerase Chain Reaction
Multiplex Polymerase Chain Reaction
Tetracycline
Tooth
15 Citations (Scopus)

New cell-based indicator assays for the detection of human cytomegalovirus infection and screening of inhibitors of viral immediate-early 2 protein activity

Luganini, A., Caposio, P., Mondini, M., Landolfo, S. & Gribaudo, G., Dec 2008, In : Journal of Applied Microbiology. 105, 6, p. 1791-1801 11 p.

Research output: Contribution to journalArticle

Immediate-Early Proteins
Cytomegalovirus Infections
Viral Proteins
Cytomegalovirus
Fluorescence
7 Citations (Scopus)

OR14I1 is a receptor for the human cytomegalovirus pentameric complex and defines viral epithelial cell tropism

Xiaofei, E., Meraner, P., Lu, P., Perreira, J. M., Aker, A. M., McDougall, W. M., Zhuge, R., Chan, G. C., Gerstein, R. M., Caposio, P., Yurochko, A. D., Brass, A. L. & Kowalik, T. F., Apr 2 2019, In : Proceedings of the National Academy of Sciences of the United States of America. 116, 14, p. 7043-7052 10 p.

Research output: Contribution to journalArticle

Open Access
Tropism
Epithelial Cells
Cytomegalovirus Infections
Cytomegalovirus
Glycoproteins
32 Citations (Scopus)

Phosphorothioate-modified oligodeoxynucleotides inhibit human cytomegalovirus replication by blocking virus entry

Luganini, A., Caposio, P., Landolfo, S. & Gribaudo, G., Mar 2008, In : Antimicrobial Agents and Chemotherapy. 52, 3, p. 1111-1120 10 p.

Research output: Contribution to journalArticle

Virus Internalization
Oligodeoxyribonucleotides
Cytomegalovirus
Antiviral Agents
Toll-Like Receptor 9
1 Citation (Scopus)

Stabilization and formulation of a recombinant Human Cytomegalovirus vector for use as a candidate HIV-1 vaccine

Kumru, O. S., Saleh-Birdjandi, S., Antunez, L. R., Sayeed, E., Robinson, D., van den Worm, S., Diemer, G. S., Perez, W., Caposio, P., Früh, K., Joshi, S. B. & Volkin, D. B., Oct 16 2019, In : Vaccine. 37, 44, p. 6696-6706 11 p.

Research output: Contribution to journalArticle

Open Access
Viral Vaccines
Human herpesvirus 5
AIDS Vaccines
Excipients
Human immunodeficiency virus 1
34 Citations (Scopus)

Targeting the NF-κB pathway through pharmacological inhibition of IKK2 prevents human cytomegalovirus replication and virus-induced inflammatory response in infected endothelial cells

Caposio, P., Musso, T., Luganini, A., Inoue, H., Gariglio, M., Landolfo, S. & Gribaudo, G., Mar 2007, In : Antiviral Research. 73, 3, p. 175-184 10 p.

Research output: Contribution to journalArticle

Virus Replication
Cytomegalovirus
Endothelial Cells
Pharmacology
Up-Regulation
16 Citations (Scopus)

The catechol 1,2 dioxygenase system of Acinetobacter radioresistens: Isoenzymes, inductors and gene localisation

Pessione, E., Giuffrida, M. G., Mazzoli, R., Caposio, P., Landolfo, S., Conti, A., Giunta, C. & Gribaudo, G., 2001, In : Biological Chemistry. 382, 8, p. 1253-1261 9 p.

Research output: Contribution to journalArticle

Catechol 1,2-Dioxygenase
Acinetobacter
Benzoates
Phenol
Isoenzymes
14 Citations (Scopus)
Serum Response Factor
Human herpesvirus 5
elks
virus replication
Cytomegalovirus
6 Citations (Scopus)

The expression of p16INK4a tumor suppressor is upregulated by human cytomegalovirus infection and required for optimal viral replication

Zannetti, C., Mondini, M., De Andrea, M., Caposio, P., Hara, E., Peters, G., Gribaudo, G., Gariglio, M. & Landolfo, S., May 25 2006, In : Virology. 349, 1, p. 79-86 8 p.

Research output: Contribution to journalArticle

Cytomegalovirus Infections
p16 Genes
Cytomegalovirus
Neoplasms
Up-Regulation
28 Citations (Scopus)

The interferon-inducible gene IFI16 secretome of endothelial cells drives the early steps of the inflammatory response

Baggetta, R., De Andrea, M., Gariano, G. R., Mondini, M., Rittà, M., Caposio, P., Cappello, P., Giovarelli, M., Gariglio, M. & Landolfo, S., Aug 2010, In : European Journal of Immunology. 40, 8, p. 2182-2189 8 p.

Research output: Contribution to journalArticle

Chemokine CCL20
Interferons
Endothelial Cells
Inflammation
Leukocyte Chemotaxis
32 Citations (Scopus)

The oxygenase component of phenol hydroxylase from Acinetobacter radioresistens S13

Divari, S., Valetti, F., Caposio, P., Pessione, E., Cavaletto, M., Griva, E., Gribaudo, G., Gilardi, G. & Giunta, C., May 2003, In : European Journal of Biochemistry. 270, 10, p. 2244-2253 10 p.

Research output: Contribution to journalArticle

phenol 2-monooxygenase
5-chloro-3-tert-butyl-2'-chloro-4'-nitrosalicylanilide
Oxygenases
Acinetobacter
methane monooxygenase
45 Citations (Scopus)

The role of cytomegalovirus in angiogenesis

Caposio, P., Orloff, S. & Streblow, D., May 2011, In : Virus Research. 157, 2, p. 204-211 8 p.

Research output: Contribution to journalArticle

Cytomegalovirus
Vascular Diseases
Transplants
Wounds and Injuries
Cytomegalovirus Infections
11 Citations (Scopus)
Cytomegalovirus
Monocytes
Endosomes
trans-Golgi Network
Infection