Michael Cohen

Associate Professor

  • 2847 Citations
  • 24 h-Index
20022019
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Adenosine Diphosphate Medicine & Life Sciences
NAD Medicine & Life Sciences
Phosphorylation Medicine & Life Sciences
Ribosomal Protein S6 Kinases Medicine & Life Sciences
Poly(ADP-ribose) Polymerases Medicine & Life Sciences
90-kDa Ribosomal Protein S6 Kinases Medicine & Life Sciences
Phosphotransferases Medicine & Life Sciences
Adenosine Diphosphate Ribose Medicine & Life Sciences

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Projects 2014 2019

Adenosine Diphosphate
Neurons
Long-Term Memory
Proteins
NAD

Research Output 2002 2019

Correction to: Structural basis for potency and promiscuity in poly(ADP-ribose) polymerase (PARP) and tankyrase inhibitors (Journal of Medicinal Chemistry (2017) 60: 4 (1262-1271) DOI: 10.1021/acs.jmedchem.6b00990)

Thorsell, A. G., Ekblad, T., Karlberg, T., Löw, M., Pinto, A. F., Trésaugues, L., Moche, M., Cohen, M. & Schüler, H., Jun 27 2019, In : Journal of Medicinal Chemistry. 62, 12, 1 p.

Research output: Contribution to journalComment/debate

Tankyrases
Pharmaceutical Chemistry
Inhibitory Concentration 50
Poly(ADP-ribose) Polymerase Inhibitors
niraparib

Fondation Leducq Transatlantic Network of Excellence Targeting Mitochondria to Treat Heart Disease

Murphy, E., Bernardi, P., Cohen, M., Di Lisa, F., Forte, M., Molkentin, J. D. & Ovize, M., Apr 26 2019, In : Circulation research. 124, 9, p. 1294-1296 3 p.

Research output: Contribution to journalComment/debate

Open Access
Heart Diseases
Reactive Oxygen Species
Mitochondria
Heart Failure
Phosphorylation
2 Citations (Scopus)

Reversible ADP-ribosylation of RNA

Munnur, D., Bartlett, E., Mikolčević, P., Kirby, I. T., Matthias Rack, J. G., Mikoč, A., Cohen, M. & Ahel, I., Jun 20 2019, In : Nucleic acids research. 47, 11, p. 5658-5669 12 p.

Research output: Contribution to journalArticle

Open Access
Adenosine Diphosphate
RNA
ADP-ribosylarginine hydrolase
NAD
ADP Ribose Transferases
1 Citation (Scopus)

Second-Generation Inhibitors of the Mitochondrial Permeability Transition Pore with Improved Plasma Stability

Šileikytė, J., Devereaux, J., de Jong, J., Schiavone, M., Jones, K., Nilsen, A., Bernardi, P., Forte, M. & Cohen, M. S., Oct 17 2019, In : ChemMedChem. 14, 20, p. 1771-1782 12 p.

Research output: Contribution to journalArticle

Plasma stability
Isoxazoles
Triazoles
Click Chemistry
Oxidative stress
4 Citations (Scopus)

Small-Molecule Inhibitors of PARPs: From Tools for Investigating ADP-Ribosylation to Therapeutics

Kirby, I. T. & Cohen, M., Jan 1 2019, In : Current Topics in Microbiology and Immunology. 420, p. 211-231 21 p.

Research output: Contribution to journalArticle

Adenosine Diphosphate
Polypharmacology
Poly(ADP-ribose) Polymerases
History
Therapeutics