Mary Kelley

Research Associate Professor

  • 1252 Citations
  • 16 h-Index
19932018
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Research Output 1993 2018

  • 1252 Citations
  • 16 h-Index
  • 18 Article
  • 1 Chapter
  • 1 Short survey
2018
21 Citations (Scopus)

Consensus recommendations for trabecular meshwork cell isolation, characterization and culture

Keller, K., Bhattacharya, S. K., Borrás, T., Brunner, T. M., Chansangpetch, S., Clark, A. F., Dismuke, W. M., Du, Y., Elliott, M. H., Ethier, C. R., Faralli, J. A., Freddo, T. F., Fuchshofer, R., Giovingo, M., Gong, H., Gonzalez, P., Huang, A., Johnstone, M. A., Kaufman, P. L., Kelley, M. & 37 others, Knepper, P. A., Kopczynski, C. C., Kuchtey, J. G., Kuchtey, R. W., Kuehn, M. H., Lieberman, R. L., Lin, S. C., Liton, P., Liu, Y., Lütjen-Drecoll, E., Mao, W., Masis-Solano, M., McDonnell, F., McDowell, C. M., Overby, D. R., Pattabiraman, P. P., Raghunathan, V. K., Rao, P. V., Rhee, D. J., Chowdhury, U. R., Russell, P., Samples, J. R., Schwartz, D., Stubbs, E. B., Tamm, E. R., Tan, J. C., Toris, C. B., Torrejon, K. Y., Vranka, J., Wirtz, M., Yorio, T., Zhang, J., Zode, G. S., Fautsch, M. P., Peters, D. M., Acott, T. & Stamer, W. D., Jun 1 2018, In : Experimental Eye Research. 171, p. 164-173 10 p.

Research output: Contribution to journalShort survey

Trabecular Meshwork
Cell Separation
Cell Culture Techniques
Ocular Hypertension
Intraocular Pressure
2015
79 Citations (Scopus)
Trabecular Meshwork
Intraocular Pressure
Glaucoma
Extracellular Matrix
Aqueous Humor
38 Citations (Scopus)

Induced pluripotent stem cells restore function in a human cell loss model of open-angle glaucoma

Abu-Hassan, D. W., Li, X., Ryan, E. I., Acott, T. & Kelley, M., Mar 1 2015, In : Stem Cells. 33, 3, p. 751-761 11 p.

Research output: Contribution to journalArticle

Induced Pluripotent Stem Cells
Open Angle Glaucoma
Trabecular Meshwork
Intraocular Pressure
Stem Cells
2014
42 Citations (Scopus)

Intraocular pressure homeostasis: Maintaining balance in a high-pressure environment

Acott, T., Kelley, M., Keller, K., Vranka, J., Abu-Hassan, D. W., Li, X., Aga, M. & Bradley, J. M., Mar 1 2014, In : Journal of Ocular Pharmacology and Therapeutics. 30, 2-3, p. 94-101 8 p.

Research output: Contribution to journalArticle

Intraocular Pressure
Homeostasis
Pressure
Glaucoma
Extracellular Matrix
2013
14 Citations (Scopus)

The effects of tenascin C knockdown on trabecular meshwork outflow resistance

Keller, K., Vranka, J., Haddadin, R. I., Kang, M. H., Oh, D. J., Rhee, D. J., Yang, Y. F., Sun, Y. Y., Kelley, M. & Acott, T., 2013, In : Investigative Ophthalmology and Visual Science. 54, 8, p. 5613-5623 11 p.

Research output: Contribution to journalArticle

Trabecular Meshwork
Tenascin
Lentivirus
Intraocular Pressure
Pressure
2011
9 Citations (Scopus)

Molecular chaperone function for myocilin

Anderssohn, A. M., Cox, K., O'Malley, K., Dees, S., Hosseini, M., Boren, L., Wagner, A., Bradley, J. M., Kelley, M. & Acott, T., Sep 2011, In : Investigative Ophthalmology and Visual Science. 52, 10, p. 7548-7555 8 p.

Research output: Contribution to journalArticle

Molecular Chaperones
Citrate (si)-Synthase
Hot Temperature
Trabecular Meshwork
Glyceraldehyde-3-Phosphate Dehydrogenases
2010

Stem cells and glaucoma

Lin, S., Kelley, M. & Samples, J., 2010, tThe Glaucoma Book: A Practical, Evidence-Based Approach to Patient Care. Springer New York, p. 953-954 2 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Glaucoma
Stem Cells
Cell- and Tissue-Based Therapy
Trabecular Meshwork
Stem Cell Research
2009
125 Citations (Scopus)

Extracellular matrix turnover and outflow resistance

Keller, K., Aga, M., Bradley, J. M., Kelley, M. & Acott, T., Apr 30 2009, In : Experimental Eye Research. 88, 4, p. 676-682 7 p.

Research output: Contribution to journalArticle

Extracellular Matrix
Intraocular Pressure
Trabecular Meshwork
Peptide Hydrolases
Podosomes
46 Citations (Scopus)

Stem cells in the trabecular meshwork: Present and future promises

Kelley, M., Rose, A. Y., Keller, K., Hessle, H., Samples, J. R. & Acott, T., Apr 30 2009, In : Experimental Eye Research. 88, 4, p. 747-751 5 p.

Research output: Contribution to journalArticle

Trabecular Meshwork
Stem Cells
Cell Division
Lasers
Trabeculectomy
2008
50 Citations (Scopus)

Effects of modifiers of glycosaminoglycan biosynthesis on outflow facility in perfusion culture

Keller, K., Bradley, J. M., Kelley, M. & Acott, T., Jun 2008, In : Investigative Ophthalmology and Visual Science. 49, 6, p. 2495-2505 11 p.

Research output: Contribution to journalArticle

Chlorates
Trabecular Meshwork
Glycosaminoglycans
Perfusion
Staining and Labeling
230 Citations (Scopus)

Extracellular matrix in the trabecular meshwork

Acott, T. & Kelley, M., Apr 2008, In : Experimental Eye Research. 86, 4, p. 543-561 19 p.

Research output: Contribution to journalArticle

Trabecular Meshwork
Extracellular Matrix
Intraocular Pressure
Aqueous Humor
Open Angle Glaucoma
44 Citations (Scopus)
Trabecular Meshwork
Extracellular Matrix
Matrix Metalloproteinase 14
Matrix Metalloproteinase 2
Cortactin
2007
59 Citations (Scopus)
Trabecular Meshwork
Alternative Splicing
Collagen Type XII
Extracellular Matrix
Protein Isoforms
14 Citations (Scopus)

p38 MAP kinase pathway and stromelysin regulation in trabecular meshwork cells

Kelley, M., Rose, A., Song, K., Lystrup, B., Samples, J. W. & Acott, T., Jul 2007, In : Investigative Ophthalmology and Visual Science. 48, 7, p. 3126-3137 12 p.

Research output: Contribution to journalArticle

Trabecular Meshwork
Matrix Metalloproteinase 3
MAP Kinase Signaling System
p38 Mitogen-Activated Protein Kinases
Interleukin-1
56 Citations (Scopus)

Synergism of TNF and IL-1 in the induction of matrix metalloproteinase-3 in trabecular meshwork

Kelley, M., Rose, A. Y., Song, K., Chen, Y., Bradley, J. M., Rookhuizen, D. & Acott, T., Jun 2007, In : Investigative Ophthalmology and Visual Science. 48, 6, p. 2634-2643 10 p.

Research output: Contribution to journalArticle

Trabecular Meshwork
Matrix Metalloproteinase 3
Interleukin-1
Matrix Metalloproteinases
Interleukin-1 Receptors
2006
34 Citations (Scopus)

IL-1 and TNF induction of matrix metalloproteinase-3 by c-Jun N-terminal kinase in trabecular meshwork

Hosseini, M., Rose, A. Y., Song, K., Bohan, C., Alexander, J. P., Kelley, M. & Acott, T., Apr 2006, In : Investigative Ophthalmology and Visual Science. 47, 4, p. 1469-1476 8 p.

Research output: Contribution to journalArticle

Trabecular Meshwork
Matrix Metalloproteinase 3
JNK Mitogen-Activated Protein Kinases
Matrix Metalloproteinases
Interleukin-1
2005
97 Citations (Scopus)

Changes in gene expression by trabecular meshwork cells in response to mechanical stretching

Vittal, V., Rose, A., Gregory, K. E., Kelley, M. & Acott, T., 2005, In : Investigative Ophthalmology and Visual Science. 46, 8, p. 2857-2868 12 p.

Research output: Contribution to journalArticle

Trabecular Meshwork
Gene Expression
Genes
Aqueous Humor
Extracellular Matrix Proteins
2003
74 Citations (Scopus)

Signaling Pathways Used in Trabecular Matrix Metalloproteinase Response to Mechanical Stretch

Bradley, J. M. B., Kelley, M., Rose, A. & Acott, T., Dec 2003, In : Investigative Ophthalmology and Visual Science. 44, 12, p. 5174-5181 8 p.

Research output: Contribution to journalArticle

Matrix Metalloproteinase 2
Matrix Metalloproteinase 14
Matrix Metalloproteinases
Trabecular Meshwork
Sirolimus
2001
131 Citations (Scopus)

Effects of mechanical stretching on trabecular matrix metalloproteinases

Bradley, J. M. B., Kelley, M., Zhu, X., Anderssohn, A. M., Alexander, J. P. & Acott, T., 2001, In : Investigative Ophthalmology and Visual Science. 42, 7, p. 1505-1513 9 p.

Research output: Contribution to journalArticle

Matrix Metalloproteinase 2
Matrix Metalloproteinases
Intraocular Pressure
Trabecular Meshwork
Extracellular Matrix
1993
89 Citations (Scopus)

α-crystallin chaperone activity is reduced by calpain II in vitro and in selenite cataract

Kelley, M., David, L., Iwasaki, N., Wright, J. & Shearer, T. T., Sep 5 1993, In : Journal of Biological Chemistry. 268, 25, p. 18844-18849 6 p.

Research output: Contribution to journalArticle

Selenious Acid
Crystallins
Calpain
Cataract
Proteolysis