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  • 21 Similar Profiles
Liver Medicine & Life Sciences
Fanconi Anemia Medicine & Life Sciences
Hepatocytes Medicine & Life Sciences
Genes Medicine & Life Sciences
Therapeutics Medicine & Life Sciences
Mutation Medicine & Life Sciences
Tyrosinemias Medicine & Life Sciences
Stem Cells Medicine & Life Sciences

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Projects 1991 2021

Liver Cancer Risk with rAAV Gene Therapy

Grompe, M. & Russell, D.

National Institutes of Health

4/1/153/31/20

Project: Research projectResearch Project

Dependovirus
Liver Neoplasms
Genetic Therapy
Hepatocellular Carcinoma
Liver

In vivo targeting of diabetes-relevant human cell types with rAAV vectors

Grompe, M., Nakai, H. & Kay, M.

National Institutes of Health

9/30/146/30/19

Project: Research projectHigh Impact Research and Research Infrastructure Cooperative Agreement Programs—Multi-Yr Funding

Dependovirus
Capsid
MicroRNAs
Epithelium
Therapeutics

Mechanisms of Bile Duct Morphogenesis

Grompe, M.

National Institutes of Health

7/1/091/31/21

Project: Research projectResearch Project

Bile Ducts
Hepatocytes
Liver
Wounds and Injuries
Cellular Reprogramming

MOLECULAR GENETICS OF FANCONI ANEMIA

Olson, S., Bagby, G., Moses, R., Grompe, M., D'Andrea, A. D., Postlethwait, J. H., D'Andrea, A. D. & Fleming, W.

National Institutes of Health

7/1/945/31/21

Project: Research projectResearch Program Projects

Fanconi Anemia
Genes
Bone Marrow
Neoplasms
Cytogenetics

CREATION AND ANALYSIS OF A MOUSE MODEL OF TYROSINEMIA

Grompe, M.

National Institutes of Health

12/1/9312/31/17

Project: Research projectResearch Project

fumarylacetoacetase
Liver
Therapeutics
Hepatocytes
Tyrosinemias

Research Output 1984 2017

  • 21549 Citations
  • 69 h-Index
  • 243 Article
  • 12 Conference contribution
  • 8 Chapter
3 Citations

A Drug Screen using Human iPSC-Derived Hepatocyte-like Cells Reveals Cardiac Glycosides as a Potential Treatment for Hypercholesterolemia

Cayo, M. A., Mallanna, S. K., Di Furio, F., Jing, R., Tolliver, L. B., Bures, M., Urick, A., Noto, F. K., Pashos, E. E., Greseth, M. D., Czarnecki, M., Traktman, P., Yang, W., Morrisey, E. E., Grompe, M., Rader, D. J. & Duncan, S. A. Apr 6 2017 In : Cell Stem Cell. 20, 4, p. 478-489.e5

Research output: Research - peer-reviewArticle

Induced Pluripotent Stem Cells
Cardiac Glycosides
Hypercholesterolemia
Hepatocytes
Pharmaceutical Preparations
1 Citations

Adult Mouse Liver Contains Two Distinct Populations of Cholangiocytes

Li, B., Dorrell, C., Canaday, P. S., Pelz, C., Haft, A., Finegold, M. & Grompe, M. 2017 (Accepted/In press) In : Stem Cell Reports.

Research output: Research - peer-reviewArticle

Liver
Population
Ducts
Organoids
Gene expression

Bioengineered AAV Capsids with Combined High Human Liver Transduction In Vivo and Unique Humoral Seroreactivity

Paulk, N. K. , Pekrun, K. , Zhu, E. , Nygaard, S. , Li, B. , Xu, J. , Chu, K. , Leborgne, C. , Dane, A. P. , Haft, A. , Zhang, Y. , Zhang, F. , Morton, C. , Valentine, M. B. , Davidoff, A. M. , Nathwani, A. C. , Mingozzi, F. , Grompe, M. , Alexander, I. E. , Lisowski, L. & 1 others Kay, M. A. 2017 (Accepted/In press) In : Molecular Therapy.

Research output: Research - peer-reviewArticle

Capsid
Liver
Hepatocytes
Serogroup
Genetic Therapy
3 Citations

Chronic Phenotype Characterization of a Large-Animal Model of Hereditary Tyrosinemia Type 1

Elgilani, F., Mao, S. A., Glorioso, J. M., Yin, M., Iankov, I. D., Singh, A., Amiot, B., Rinaldo, P., Marler, R. J., Ehman, R. L., Grompe, M., Lillegard, J. B., Hickey, R. D. & Nyberg, S. L. Jan 1 2017 In : American Journal of Pathology. 187, 1, p. 33-41 9 p.

Research output: Research - peer-reviewArticle

Tyrosinemias
Swine
Animal Models
Phenotype
Fibrosis

Fah knockout animals as models for therapeutic liver repopulation

Grompe, M. 2017 Advances in Experimental Medicine and Biology. Springer New York LLC, Vol. 959, p. 215-230 16 p. (Advances in Experimental Medicine and Biology; vol. 959)

Research output: ResearchChapter

Animal Models
Liver
Therapeutics
Animals
Hepatocytes