Marc Freeman

Professor

  • 4670 Citations
  • 34 h-Index
19992019

Research output per year

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Research Output

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Article

Activation of autophagy during cell death requires the engulfment receptor Draper

McPhee, C. K., Logan, M. A., Freeman, M. R. & Baehrecke, E. H., Jun 24 2010, In : Nature. 465, 7301, p. 1093-1096 4 p.

Research output: Contribution to journalArticle

94 Scopus citations

Activity-dependent regulation of astrocyte GAT levels during synaptogenesis

Muthukumar, A. K., Stork, T. & Freeman, M. R., Oct 1 2014, In : Nature Neuroscience. 17, 10, p. 1340-1350 11 p.

Research output: Contribution to journalArticle

49 Scopus citations

Age-dependent TDP-43-mediated motor neuron degeneration requires GSK3, hat-trick, and xmas-2

Sreedharan, J., Neukomm, L. J., Brown, R. H. & Freeman, M. R., Aug 17 2015, In : Current Biology. 25, 16, p. 2130-2136 7 p.

Research output: Contribution to journalArticle

29 Scopus citations

Analysis of glial cell development and function in Drosophila

Stork, T., Bernardos, R. & Freeman, M. R., Jan 2012, In : Cold Spring Harbor Protocols. 7, 1, p. 1-17 17 p.

Research output: Contribution to journalArticle

69 Scopus citations

A novel family of divergent seven-transmembrane proteins: Candidate odorant receptors in Drosophila

Clyne, P. J., Warr, C. G., Freeman, M. R., Lessing, D., Kim, J. & Carlson, J. R., Feb 1999, In : Neuron. 22, 2, p. 327-338 12 p.

Research output: Contribution to journalArticle

Open Access
762 Scopus citations

Astrocytes engage unique molecular programs to engulf pruned neuronal debris from distinct subsets of neurons

Tasdemir-Yilmaz, O. E. & Freeman, M. R., Jan 1 2014, In : Genes and Development. 28, 1, p. 20-33 14 p.

Research output: Contribution to journalArticle

104 Scopus citations

Asymmetric Prospero localization is required to generate mixed neuronal/glial lineages in the Drosophila CNS

Freeman, M. R. & Doe, C. Q., Nov 20 2001, In : Development. 128, 20, p. 4103-4112 10 p.

Research output: Contribution to journalArticle

56 Scopus citations

Attenuated traumatic axonal injury and improved functional outcome after traumatic brain injury in mice lacking Sarm1

Henninger, N., Bouley, J., Sikoglu, E. M., An, J., Moore, C. M., King, J. A., Bowser, R., Freeman, M. & Brown, R. H., Apr 1 2016, In : Brain. 139, 4, p. 1094-1105 12 p.

Research output: Contribution to journalArticle

57 Scopus citations

Axon Death Pathways Converge on Axundead to Promote Functional and Structural Axon Disassembly

Neukomm, L. J., Burdett, T. C., Seeds, A. M., Hampel, S., Coutinho-Budd, J. C., Farley, J. E., Wong, J., Karadeniz, Y. B., Osterloh, J. M., Sheehan, A. E. & Freeman, M., Jul 5 2017, In : Neuron. 95, 1, p. 78-91 14 p.

Research output: Contribution to journalArticle

32 Scopus citations

Axon degeneration induces glial responses through Draper-TRAF4-JNK signalling

Lu, T. Y., MacDonald, J. M., Neukomm, L. J., Sheehan, A. E., Bradshaw, R., Logan, M. A. & Freeman, M. R., Feb 6 2017, In : Nature communications. 8, 14355.

Research output: Contribution to journalArticle

18 Scopus citations

Combining Comparative Proteomics and Molecular Genetics Uncovers Regulators of Synaptic and Axonal Stability and Degeneration In Vivo

Wishart, T. M., Rooney, T. M., Lamont, D. J., Wright, A. K., Morton, A. J., Jackson, M., Freeman, M. R. & Gillingwater, T. H., Aug 2012, In : PLoS genetics. 8, 8, e1002936.

Research output: Contribution to journalArticle

37 Scopus citations

Deletions within its subcellular targeting domain enhance the axon protective capacity of Nmnat2 in vivo

Milde, S., Fox, A. N., Freeman, M. R. & Coleman, M. P., 2013, In : Scientific Reports. 3, 2567.

Research output: Contribution to journalArticle

20 Scopus citations

Distinct molecular pathways mediate glial activation and engulfment of axonal debris after axotomy

Ziegenfuss, J. S., Doherty, J. & Freeman, M. R., Jul 1 2012, In : Nature Neuroscience. 15, 7, p. 979-987 9 p.

Research output: Contribution to journalArticle

41 Scopus citations

Draper-dependent glial phagocytic activity is mediated by Src and Syk family kinase signalling

Ziegenfuss, J. S., Biswas, R., Avery, M. A., Hong, K., Sheehan, A. E., Yeung, Y. G., Stanley, E. R. & Freeman, M. R., Jun 12 2008, In : Nature. 453, 7197, p. 935-939 5 p.

Research output: Contribution to journalArticle

122 Scopus citations
15 Scopus citations

Drosophila models of neuronal injury

Rooney, T. M. & Freeman, M. R., Apr 2014, In : ILAR Journal. 54, 3, p. 291-295 5 p., ilt057.

Research output: Contribution to journalArticle

8 Scopus citations

dSarm/Sarm1 is required for activation of an injury-induced axon death pathway

Osterloh, J. M., Yang, J., Rooney, T. M., Fox, A. N., Adalbert, R., Powell, E. H., Sheehan, A. E., Avery, M. A., Hackett, R., Logan, M. A., MacDonald, J. M., Ziegenfuss, J. S., Milde, S., Hou, Y. J., Nathan, C., Ding, A., Brown, R. H., Conforti, L., Coleman, M., Tessier-Lavigne, M. & 2 others, Züchner, S. & Freeman, M. R., Jul 27 2012, In : Science. 337, 6093, p. 481-484 4 p.

Research output: Contribution to journalArticle

254 Scopus citations

Ecdysone response genes govern egg chamber development during mid-oogenesis in Drosophila

Buszczak, M., Freeman, M. R., Carlson, J. R., Bender, M., Cooley, L. & Segraves, W. A., Oct 1 1999, In : Development. 126, 20, p. 4581-4589 9 p.

Research output: Contribution to journalArticle

199 Scopus citations

Ensheathing glia function as phagocytes in the adult Drosophila brain

Doherty, J., Logan, M. A., Taşdemir, Ö. E. & Freeman, M. R., Apr 15 2009, In : Journal of Neuroscience. 29, 15, p. 4768-4781 14 p.

Research output: Contribution to journalArticle

167 Scopus citations

Focal adhesion molecules regulate astrocyte morphology and glutamate transporters to suppress seizure-like behavior

Cho, S., Muthukumar, A. K., Stork, W. T., Coutinho-Budd, J. C. & Freeman, M., Oct 30 2018, In : Proceedings of the National Academy of Sciences of the United States of America. 115, 44, p. 11316-11321 6 p.

Research output: Contribution to journalArticle

8 Scopus citations

Glia and muscle sculpt neuromuscular arbors by engulfing destabilized synaptic boutons and shed presynaptic debris

Fuentes-Medel, Y., Logan, M. A., Ashley, J., Ataman, B., Budnik, V. & Freeman, M. R., Aug 1 2009, In : PLoS Biology. 7, 8, e1000184.

Research output: Contribution to journalArticle

89 Scopus citations

Glial wingless/wnt regulates glutamate receptor clustering and synaptic physiology at the Drosophila neuromuscular junction

Kerr, K. S., Fuentes-Medel, Y., Brewer, C., Barria, R., Ashley, J., Abruzzi, K. C., Sheehan, A., Tasdemir-Yilmaz, O. E., Freeman, M. R. & Budnik, V., 2014, In : Journal of Neuroscience. 34, 8, p. 2910-2920 11 p.

Research output: Contribution to journalArticle

46 Scopus citations

Glutathione S-Transferase Regulates Mitochondrial Populations in Axons through Increased Glutathione Oxidation

Smith, G. A., Lin, T. H., Sheehan, A. E., Van der Goes van Naters, W., Neukomm, L. J., Graves, H. K., Bis-Brewer, D. M., Züchner, S. & Freeman, M. R., Jul 3 2019, In : Neuron. 103, 1, p. 52-65.e6

Research output: Contribution to journalArticle

Open Access
5 Scopus citations

Integration of a retrograde signal during synapse formation by glia-secreted TGF-β ligand

Fuentes-Medel, Y., Ashley, J., Barria, R., Maloney, R., Freeman, M. & Budnik, V., Oct 9 2012, In : Current Biology. 22, 19, p. 1831-1838 8 p.

Research output: Contribution to journalArticle

67 Scopus citations

Loss of Sarm1 does not suppress motor neuron degeneration in the SOD1 G93A mouse model of amyotrophic lateral sclerosis

Peters, O. M., Lewis, E. A., Osterloh, J. M., Weiss, A., Salameh, J. S., Metterville, J., Brown, R. H. & Freeman, M. R., 2018, In : Human molecular genetics. 27, 21, p. 3761-3771 11 p.

Research output: Contribution to journalArticle

12 Scopus citations

Negative regulation of glial engulfment activity by Draper terminates glial responses to axon injury

Logan, M. A., Hackett, R., Doherty, J., Sheehan, A., Speese, S. D. & Freeman, M. R., May 1 2012, In : Nature Neuroscience. 15, 5, p. 722-730 9 p.

Research output: Contribution to journalArticle

44 Scopus citations

Neural JNK3 regulates blood flow recovery after hindlimb ischemia in mice via an Egr1/Creb1 axis

Kant, S., Craige, S. M., Chen, K., Reif, M. M., Learnard, H., Kelly, M., Caliz, A. D., Tran, K. V., Ramo, K., Peters, O. M., Freeman, M., Davis, R. J. & Keaney, J. F., Dec 1 2019, In : Nature communications. 10, 1, 4223.

Research output: Contribution to journalArticle

Open Access
2 Scopus citations

Neuromodulators signal through astrocytes to alter neural circuit activity and behaviour

Ma, Z., Stork, W. T., Bergles, D. E. & Freeman, M., 2016, In : Nature. 539, 7629, p. 428-432 5 p.

Research output: Contribution to journalArticle

66 Scopus citations

Neuron-Glia interactions through the heartless fgf receptor signaling pathway mediate morphogenesis of drosophila astrocytes

Stork, T., Sheehan, A., Tasdemir-Yilmaz, O. E. & Freeman, M. R., Jul 16 2014, In : Neuron. 83, 2, p. 388-403 16 p.

Research output: Contribution to journalArticle

94 Scopus citations

PI3K Signaling and Stat92E Converge to Modulate Glial Responsiveness to Axonal Injury

Doherty, J., Sheehan, A. E., Bradshaw, R., Fox, A. N., Lu, T. Y. & Freeman, M. R., 2014, In : PLoS Biology. 12, 11

Research output: Contribution to journalArticle

24 Scopus citations

Polymodal Nociception in Drosophila Requires Alternative Splicing of TrpA1

Gu, P., Gong, J., Shang, Y., Wang, F., Ruppell, K. T., Ma, Z., Sheehan, A. E., Freeman, M. R. & Xiang, Y., Dec 2 2019, In : Current Biology. 29, 23, p. 3961-3973.e6

Research output: Contribution to journalArticle

Prevalent presence of periodic actin-spectrin-based membrane skeleton in a broad range of neuronal cell types and animal species

He, J., Zhou, R., Wu, Z., Carrasco, M. A., Kurshan, P. T., Farley, J. E., Simon, D. J., Wang, G., Han, B., Hao, J., Heller, E., Freeman, M. R., Shen, K., Maniatis, T., Tessier-Lavigne, M. & Zhuang, X., May 24 2016, In : Proceedings of the National Academy of Sciences of the United States of America. 113, 21, p. 6029-6034 6 p.

Research output: Contribution to journalArticle

68 Scopus citations

Rapid in vivo forward genetic approach for identifying axon death genes in Drosophila

Neukomm, L. J., Burdett, T. C., Gonzalez, M. A., Züchner, S. & Freeman, M. R., Jul 8 2014, In : Proceedings of the National Academy of Sciences of the United States of America. 111, 27, p. 9965-9970 6 p.

Research output: Contribution to journalArticle

28 Scopus citations

The c-Jun kinase signaling cascade promotes glial engulfment activity through activation of draper and phagocytic function

MacDonald, J. M., Doherty, J., Hackett, R. & Freeman, M. R., Sep 1 2013, In : Cell Death and Differentiation. 20, 9, p. 1140-1148 9 p.

Research output: Contribution to journalArticle

30 Scopus citations

The dare gene: Steroid hormone production, olfactory behavior, and neural degeneration in Drosophila

Freeman, M. R., Dobritsa, A., Gaines, P., Segraves, W. A. & Carlson, J. R., Oct 1 1999, In : Development. 126, 20, p. 4591-4602 12 p.

Research output: Contribution to journalArticle

88 Scopus citations

The Drosophila Cell Corpse Engulfment Receptor Draper Mediates Glial Clearance of Severed Axons

MacDonald, J. M., Beach, M. G., Porpiglia, E., Sheehan, A. E., Watts, R. J. & Freeman, M. R., Jun 1 2006, In : Neuron. 50, 6, p. 869-881 13 p.

Research output: Contribution to journalArticle

294 Scopus citations

The secreted neurotrophin spätzle 3 promotes glial morphogenesis and supports neuronal survival and function

Coutinho-Budd, J. C., Sheehan, A. E. & Freeman, M. R., Oct 15 2017, In : Genes and Development. 31, 20, p. 2023-2038 16 p.

Research output: Contribution to journalArticle

15 Scopus citations

Transcription factor Pebbled/RREB1 regulates injury-induced axon degeneration

Farley, J. E., Burdett, T. C., Barria, R., Neukomm, L. J., Kenna, K. P., Landers, J. E. & Freeman, M. R., Feb 6 2018, In : Proceedings of the National Academy of Sciences of the United States of America. 115, 6, p. 1358-1363 6 p.

Research output: Contribution to journalArticle

13 Scopus citations

Unwrapping glial biology: Gcm target genes regulating glial development, diversification, and function

Freeman, M. R., Delrow, J., Kim, J., Johnson, E. & Doe, C. Q., May 22 2003, In : Neuron. 38, 4, p. 567-580 14 p.

Research output: Contribution to journalArticle

268 Scopus citations

Whole genome sequencing and a new bioinformatics platform allow for rapid gene identification in d. melanogaster EMS screens

Gonzalez, M. A., VanBooven, D., Hulme, W., Ulloa, R. H., Lebrigio, R. F. A., Osterloh, J., Logan, M., Freeman, M. & Zuchner, S., Dec 5 2012, In : Biology. 1, 3, p. 766-777 12 p.

Research output: Contribution to journalArticle

8 Scopus citations

Wld S prevents axon degeneration through increased mitochondrial flux and enhanced mitochondrial Ca 2+ buffering

Avery, M. A., Rooney, T. M., Pandya, J. D., Wishart, T. M., Gillingwater, T. H., Geddes, J. W., Sullivan, P. G. & Freeman, M. R., Apr 10 2012, In : Current Biology. 22, 7, p. 596-600 5 p.

Research output: Contribution to journalArticle

96 Scopus citations

Wld s requires Nmnatl enzymatic activity and N16- VCP interactions to suppress Wallerian degeneration

Avery, M. A., Sheehan, A. E., Kerr, K. S., Wang, J. & Freeman, M. R., Feb 23 2009, In : Journal of Cell Biology. 184, 4, p. 501-513 13 p.

Research output: Contribution to journalArticle

95 Scopus citations