Marc Freeman

Professor

  • 4284 Citations
  • 32 h-Index
19992019
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Research Output 1999 2019

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Article
2019
1 Citation (Scopus)

Glutathione S-Transferase Regulates Mitochondrial Populations in Axons through Increased Glutathione Oxidation

Smith, G. A., Lin, T. H., Sheehan, A. E., Van der Goes van Naters, W., Neukomm, L. J., Graves, H. K., Bis-Brewer, D. M., Züchner, S. & Freeman, M., Jul 3 2019, In : Neuron. 103, 1, p. 52-65.e6

Research output: Contribution to journalArticle

Open Access
Glutathione Disulfide
Glutathione Transferase
Mitochondrial Dynamics
Glutathione
Axons

Neural JNK3 regulates blood flow recovery after hindlimb ischemia in mice via an Egr1/Creb1 axis

Kant, S., Craige, S. M., Chen, K., Reif, M. M., Learnard, H., Kelly, M., Caliz, A. D., Tran, K. V., Ramo, K., Peters, O. M., Freeman, M., Davis, R. J. & Keaney, J. F., Dec 1 2019, In : Nature communications. 10, 1, 4223.

Research output: Contribution to journalArticle

Open Access
ischemia
Hindlimb
blood flow
mice
Blood
2018
4 Citations (Scopus)

Focal adhesion molecules regulate astrocyte morphology and glutamate transporters to suppress seizure-like behavior

Cho, S., Muthukumar, A. K., Stork, W. T., Coutinho-Budd, J. C. & Freeman, M., Oct 30 2018, In : Proceedings of the National Academy of Sciences of the United States of America. 115, 44, p. 11316-11321 6 p.

Research output: Contribution to journalArticle

Amino Acid Transport System X-AG
Focal Adhesions
Astrocytes
Seizures
Matrix Metalloproteinase 1
6 Citations (Scopus)

Loss of Sarm1 does not suppress motor neuron degeneration in the SOD1G93A mouse model of amyotrophic lateral sclerosis

Peters, O. M., Lewis, E. A., Osterloh, J. M., Weiss, A., Salameh, J. S., Metterville, J., Brown, R. H. & Freeman, M., Nov 1 2018, In : Human Molecular Genetics. 27, 21, p. 3761-3771 11 p.

Research output: Contribution to journalArticle

Nerve Degeneration
Amyotrophic Lateral Sclerosis
Motor Neurons
Axons
Axotomy
7 Citations (Scopus)

Transcription factor Pebbled/RREB1 regulates injury-induced axon degeneration

Farley, J. E., Burdett, T. C., Barria, R., Neukomm, L. J., Kenna, K. P., Landers, J. E. & Freeman, M., Feb 6 2018, In : Proceedings of the National Academy of Sciences of the United States of America. 115, 6, p. 1358-1363 6 p.

Research output: Contribution to journalArticle

Axons
Carrier Proteins
Transcription Factors
Wounds and Injuries
Sensory Receptor Cells
2017
18 Citations (Scopus)

Axon Death Pathways Converge on Axundead to Promote Functional and Structural Axon Disassembly

Neukomm, L. J., Burdett, T. C., Seeds, A. M., Hampel, S., Coutinho-Budd, J. C., Farley, J. E., Wong, J., Karadeniz, Y. B., Osterloh, J. M., Sheehan, A. E. & Freeman, M., Jul 5 2017, In : Neuron. 95, 1, p. 78-91 14 p.

Research output: Contribution to journalArticle

Axons
Diptera
NAD
Axotomy
Neurodegenerative Diseases
15 Citations (Scopus)

Axon degeneration induces glial responses through Draper-TRAF4-JNK signalling

Lu, T. Y., MacDonald, J. M., Neukomm, L. J., Sheehan, A. E., Bradshaw, R., Logan, M. & Freeman, M., Feb 6 2017, In : Nature Communications. 8, 14355.

Research output: Contribution to journalArticle

TNF Receptor-Associated Factor 4
axons
degeneration
Neuroglia
Axons
13 Citations (Scopus)

The secreted neurotrophin spätzle 3 promotes glial morphogenesis and supports neuronal survival and function

Coutinho-Budd, J. C., Sheehan, A. E. & Freeman, M., Oct 15 2017, In : Genes and Development. 31, 20, p. 2023-2038 16 p.

Research output: Contribution to journalArticle

Neurotrophin 3
Morphogenesis
Neuroglia
Neurons
Central Nervous System
2016
43 Citations (Scopus)

Attenuated traumatic axonal injury and improved functional outcome after traumatic brain injury in mice lacking Sarm1

Henninger, N., Bouley, J., Sikoglu, E. M., An, J., Moore, C. M., King, J. A., Bowser, R., Freeman, M. & Brown, R. H., Apr 1 2016, In : Brain. 139, 4, p. 1094-1105 12 p.

Research output: Contribution to journalArticle

Wounds and Injuries
Axons
Traumatic Brain Injury
Mouse
Brain Concussion
51 Citations (Scopus)

Neuromodulators signal through astrocytes to alter neural circuit activity and behaviour

Ma, Z., Stork, W. T., Bergles, D. E. & Freeman, M., 2016, In : Nature. 539, 7629, p. 428-432 5 p.

Research output: Contribution to journalArticle

Astrocytes
Neurotransmitter Agents
Octopamine
Tyramine
Dopaminergic Neurons
55 Citations (Scopus)

Prevalent presence of periodic actin-spectrin-based membrane skeleton in a broad range of neuronal cell types and animal species

He, J., Zhou, R., Wu, Z., Carrasco, M. A., Kurshan, P. T., Farley, J. E., Simon, D. J., Wang, G., Han, B., Hao, J., Heller, E., Freeman, M., Shen, K., Maniatis, T., Tessier-Lavigne, M. & Zhuang, X., May 24 2016, In : Proceedings of the National Academy of Sciences of the United States of America. 113, 21, p. 6029-6034 6 p.

Research output: Contribution to journalArticle

Spectrin
Skeleton
Actins
Dendrites
Membranes
2015
25 Citations (Scopus)

Age-dependent TDP-43-mediated motor neuron degeneration requires GSK3, hat-trick, and xmas-2

Sreedharan, J., Neukomm, L. J., Brown, R. H. & Freeman, M., Aug 17 2015, In : Current Biology. 25, 16, p. 2130-2136 7 p.

Research output: Contribution to journalArticle

Wallerian Degeneration
Nerve Degeneration
Motor Neurons
motor neurons
Neurons
2014
38 Citations (Scopus)

Activity-dependent regulation of astrocyte GAT levels during synaptogenesis

Muthukumar, A. K., Stork, W. T. & Freeman, M., Oct 1 2014, In : Nature Neuroscience. 17, 10, p. 1340-1350 11 p.

Research output: Contribution to journalArticle

GABA Plasma Membrane Transport Proteins
Astrocytes
Synapses
GABA Receptors
Neuropil
95 Citations (Scopus)

Astrocytes engage unique molecular programs to engulf pruned neuronal debris from distinct subsets of neurons

Tasdemir-Yilmaz, O. E. & Freeman, M., Jan 1 2014, In : Genes and Development. 28, 1, p. 20-33 14 p.

Research output: Contribution to journalArticle

Neuroglia
Astrocytes
Neurites
Neurons
Mushroom Bodies
13 Citations (Scopus)
Myoblasts
Neuroglia
Phosphotransferases
Guanine Nucleotide Exchange Factors
Wounds and Injuries
8 Citations (Scopus)

Drosophila models of neuronal injury

Rooney, T. M. & Freeman, M., Apr 2014, In : ILAR Journal. 54, 3, p. 291-295 5 p., ilt057.

Research output: Contribution to journalArticle

neurites
Neurites
Drosophila
fruit flies
Fruits
41 Citations (Scopus)

Glial wingless/wnt regulates glutamate receptor clustering and synaptic physiology at the Drosophila neuromuscular junction

Kerr, K. S., Fuentes-Medel, Y., Brewer, C., Barria, R., Ashley, J., Abruzzi, K. C., Sheehan, A., Tasdemir-Yilmaz, O. E., Freeman, M. & Budnik, V., 2014, In : Journal of Neuroscience. 34, 8, p. 2910-2920 11 p.

Research output: Contribution to journalArticle

Neuromuscular Junction
Glutamate Receptors
Neuroglia
Drosophila
Cluster Analysis
85 Citations (Scopus)

Neuron-Glia interactions through the heartless fgf receptor signaling pathway mediate morphogenesis of drosophila astrocytes

Stork, W. T., Sheehan, A., Tasdemir-Yilmaz, O. E. & Freeman, M., Jul 16 2014, In : Neuron. 83, 2, p. 388-403 16 p.

Research output: Contribution to journalArticle

Morphogenesis
Neuroglia
Astrocytes
Drosophila
Neurons
21 Citations (Scopus)

PI3K Signaling and Stat92E Converge to Modulate Glial Responsiveness to Axonal Injury

Doherty, J., Sheehan, A. E., Bradshaw, R., Fox, A. N., Lu, T. Y. & Freeman, M., 2014, In : PLoS Biology. 12, 11

Research output: Contribution to journalArticle

phosphatidylinositol 3-kinase
neuroglia
Phosphatidylinositol 3-Kinases
Neuroglia
automobiles
24 Citations (Scopus)

Rapid in vivo forward genetic approach for identifying axon death genes in Drosophila

Neukomm, L. J., Burdett, T. C., Gonzalez, M. A., Züchner, S. & Freeman, M., Jul 8 2014, In : Proceedings of the National Academy of Sciences of the United States of America. 111, 27, p. 9965-9970 6 p.

Research output: Contribution to journalArticle

Drosophila
Axons
Genes
Wallerian Degeneration
Axotomy
2013
18 Citations (Scopus)

Deletions within its subcellular targeting domain enhance the axon protective capacity of Nmnat2 in vivo

Milde, S., Fox, A. N., Freeman, M. & Coleman, M. P., 2013, In : Scientific Reports. 3, 2567.

Research output: Contribution to journalArticle

Axons
Protein Isoforms
Wallerian Degeneration
Olfactory Receptor Neurons
Transport Vesicles
28 Citations (Scopus)

The c-Jun kinase signaling cascade promotes glial engulfment activity through activation of draper and phagocytic function

MacDonald, J. M., Doherty, J., Hackett, R. & Freeman, M., Sep 2013, In : Cell Death and Differentiation. 20, 9, p. 1140-1148 9 p.

Research output: Contribution to journalArticle

Neuroglia
Phosphotransferases
JNK Mitogen-Activated Protein Kinases
Drosophila
Axons
2012
66 Citations (Scopus)

Analysis of glial cell development and function in Drosophila

Stork, W. T., Bernardos, R. & Freeman, M., Jan 2012, In : Cold Spring Harbor Protocols. 7, 1, p. 1-17 17 p.

Research output: Contribution to journalArticle

Neuroglia
Drosophila
Cytology
Neurology
Drosophila melanogaster
32 Citations (Scopus)

Combining Comparative Proteomics and Molecular Genetics Uncovers Regulators of Synaptic and Axonal Stability and Degeneration In Vivo

Wishart, T. M., Rooney, T. M., Lamont, D. J., Wright, A. K., Morton, A. J., Jackson, M., Freeman, M. & Gillingwater, T. H., Aug 2012, In : PLoS Genetics. 8, 8, e1002936.

Research output: Contribution to journalArticle

proteomics
synapse
molecular genetics
Proteomics
Synapses
37 Citations (Scopus)

Distinct molecular pathways mediate glial activation and engulfment of axonal debris after axotomy

Ziegenfuss, J. S., Doherty, J. & Freeman, M., Jul 2012, In : Nature Neuroscience. 15, 7, p. 979-987 9 p.

Research output: Contribution to journalArticle

Axotomy
Neuroglia
Phagocytosis
Nervous System Trauma
Guanine Nucleotide Exchange Factors
218 Citations (Scopus)

dSarm/Sarm1 is required for activation of an injury-induced axon death pathway

Osterloh, J. M., Yang, J., Rooney, T. M., Fox, A. N., Adalbert, R., Powell, E. H., Sheehan, A. E., Avery, M. A., Hackett, R., Logan, M., MacDonald, J. M., Ziegenfuss, J. S., Milde, S., Hou, Y. J., Nathan, C., Ding, A., Brown, R. H., Conforti, L., Coleman, M., Tessier-Lavigne, M. & 2 others, Züchner, S. & Freeman, M., Jul 27 2012, In : Science. 337, 6093, p. 481-484 4 p.

Research output: Contribution to journalArticle

Axons
Wounds and Injuries
Interleukin Receptors
Armadillos
Wallerian Degeneration
65 Citations (Scopus)

Integration of a retrograde signal during synapse formation by glia-secreted TGF-β ligand

Fuentes-Medel, Y., Ashley, J., Barria, R., Maloney, R., Freeman, M. & Budnik, V., Oct 9 2012, In : Current Biology. 22, 19, p. 1831-1838 8 p.

Research output: Contribution to journalArticle

synapse
Neuroglia
Synapses
Muscle
boats
40 Citations (Scopus)

Negative regulation of glial engulfment activity by Draper terminates glial responses to axon injury

Logan, M., Hackett, R., Doherty, J., Sheehan, A., Speese, S. & Freeman, M., May 2012, In : Nature Neuroscience. 15, 5, p. 722-730 9 p.

Research output: Contribution to journalArticle

Neuroglia
Axons
Wounds and Injuries
Axotomy
Tyrosine
8 Citations (Scopus)

Whole genome sequencing and a new bioinformatics platform allow for rapid gene identification in d. melanogaster EMS screens

Gonzalez, M. A., VanBooven, D., Hulme, W., Ulloa, R. H., Lebrigio, R. F. A., Osterloh, J., Logan, M., Freeman, M. & Zuchner, S., Dec 5 2012, In : Biology. 1, 3, p. 766-777 12 p.

Research output: Contribution to journalArticle

Ethyl Methanesulfonate
ethyl methanesulfonate
Melanogaster
Bioinformatics
Computational Biology
90 Citations (Scopus)

Wld S prevents axon degeneration through increased mitochondrial flux and enhanced mitochondrial Ca 2+ buffering

Avery, M. A., Rooney, T. M., Pandya, J. D., Wishart, T. M., Gillingwater, T. H., Geddes, J. W., Sullivan, P. G. & Freeman, M., Apr 10 2012, In : Current Biology. 22, 7, p. 596-600 5 p.

Research output: Contribution to journalArticle

Mitochondria
axons
Axons
Wallerian Degeneration
mitochondria
2010
89 Citations (Scopus)

Activation of autophagy during cell death requires the engulfment receptor Draper

McPhee, C. K., Logan, M., Freeman, M. & Baehrecke, E. H., Jun 24 2010, In : Nature. 465, 7301, p. 1093-1096 4 p.

Research output: Contribution to journalArticle

Autophagy
Cell Death
Salivary Glands
Cell Survival
Starvation
2009
155 Citations (Scopus)

Ensheathing glia function as phagocytes in the adult Drosophila brain

Doherty, J., Logan, M., Taşdemir, Ö. E. & Freeman, M., Apr 15 2009, In : Journal of Neuroscience. 29, 15, p. 4768-4781 14 p.

Research output: Contribution to journalArticle

Phagocytes
Neuroglia
Drosophila
Brain
Axons
83 Citations (Scopus)

Glia and muscle sculpt neuromuscular arbors by engulfing destabilized synaptic boutons and shed presynaptic debris

Fuentes-Medel, Y., Logan, M., Ashley, J., Ataman, B., Budnik, V. & Freeman, M., Aug 2009, In : PLoS Biology. 7, 8, e1000184.

Research output: Contribution to journalArticle

Neuromuscular Junction
Presynaptic Terminals
Debris
Neuroglia
Muscle
94 Citations (Scopus)

Wld s requires Nmnatl enzymatic activity and N16- VCP interactions to suppress Wallerian degeneration

Avery, M. A., Sheehan, A. E., Kerr, K. S., Wang, J. & Freeman, M., Feb 23 2009, In : Journal of Cell Biology. 184, 4, p. 501-513 13 p.

Research output: Contribution to journalArticle

Wallerian Degeneration
Nicotinamide Mononucleotide
Axons
Drosophila melanogaster
Drosophila
2008
117 Citations (Scopus)

Draper-dependent glial phagocytic activity is mediated by Src and Syk family kinase signalling

Ziegenfuss, J. S., Biswas, R., Avery, M. A., Hong, K., Sheehan, A. E., Yeung, Y. G., Stanley, E. R. & Freeman, M., Jun 12 2008, In : Nature. 453, 7197, p. 935-939 5 p.

Research output: Contribution to journalArticle

Sharks
src-Family Kinases
Phagocytosis
Neuroglia
Immunoreceptor Tyrosine-Based Activation Motif
2007
26 Citations (Scopus)

The scoop on the fly brain: Glial engulfment functions in Drosophila

Logan, M. & Freeman, M., Feb 2007, In : Neuron Glia Biology. 3, 1, p. 63-74 12 p.

Research output: Contribution to journalArticle

Neuroglia
Diptera
Drosophila
Brain
Neurites
2006
272 Citations (Scopus)

The Drosophila Cell Corpse Engulfment Receptor Draper Mediates Glial Clearance of Severed Axons

MacDonald, J. M., Beach, M. G., Porpiglia, E., Sheehan, A. E., Watts, R. J. & Freeman, M., Jun 2006, In : Neuron. 50, 6, p. 869-881 13 p.

Research output: Contribution to journalArticle

Cadaver
Neuroglia
Drosophila
Axons
Wounds and Injuries
2003
258 Citations (Scopus)

Unwrapping glial biology: Gcm target genes regulating glial development, diversification, and function

Freeman, M., Delrow, J., Kim, J., Johnson, E. & Doe, C. Q., May 22 2003, In : Neuron. 38, 4, p. 567-580 14 p.

Research output: Contribution to journalArticle

Neuroglia
Genes
Drosophila
Human Development
Locomotion
2001
55 Citations (Scopus)

Asymmetric Prospero localization is required to generate mixed neuronal/glial lineages in the Drosophila CNS

Freeman, M. & Doe, C. Q., 2001, In : Development. 128, 20, p. 4103-4112 10 p.

Research output: Contribution to journalArticle

Neuroglia
Drosophila
Neurons
Cell Division
Up-Regulation
1999
730 Citations (Scopus)

A novel family of divergent seven-transmembrane proteins: Candidate odorant receptors in Drosophila

Clyne, P. J., Warr, C. G., Freeman, M., Lessing, D., Kim, J. & Carlson, J. R., 1999, In : Neuron. 22, 2, p. 327-338 12 p.

Research output: Contribution to journalArticle

Odorant Receptors
Olfactory Receptor Neurons
Drosophila
Insects
POU Domain Factors
195 Citations (Scopus)

Ecdysone response genes govern egg chamber development during mid-oogenesis in Drosophila

Buszczak, M., Freeman, M., Carlson, J. R., Bender, M., Cooley, L. & Segraves, W. A., Oct 1999, In : Development. 126, 20, p. 4581-4589 9 p.

Research output: Contribution to journalArticle

Ecdysone
Oogenesis
Drosophila
Ovum
Genes
87 Citations (Scopus)

The dare gene: Steroid hormone production, olfactory behavior, and neural degeneration in Drosophila

Freeman, M., Dobritsa, A., Gaines, P., Segraves, W. A. & Carlson, J. R., Oct 1999, In : Development. 126, 20, p. 4591-4602 12 p.

Research output: Contribution to journalArticle

Drosophila
Steroids
Hormones
Genes
Insect Hormones