• 5945 Citations
  • 43 h-Index
1982 …2020
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Research Output 1982 2019

  • 5945 Citations
  • 43 h-Index
  • 185 Article
  • 1 Chapter
  • 1 Conference contribution
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Article
2005
69 Citations (Scopus)

γN-crystallin and the evolution of the βγ-crystallin superfamily in vertebrates

Wistow, G., Wyatt, K., David, L., Gao, C., Bateman, O., Bernstein, S., Tomarev, S., Segovia, L., Slingsby, C. & Vihtelic, T., May 2005, In : FEBS Journal. 272, 9, p. 2276-2291 16 p.

Research output: Contribution to journalArticle

Crystallins
Vertebrates
Fish
Fishes
Mammals
2004
40 Citations (Scopus)

Ectopic Pax6 expression disturbs lens fiber cell differentiation

Duncan, M. K., Xie, L., David, L., Robinson, M. L., Taube, J. R., Cui, W. & Reneker, L. W., Oct 2004, In : Investigative Ophthalmology and Visual Science. 45, 10, p. 3589-3598 10 p.

Research output: Contribution to journalArticle

Crystallins
Lenses
Cell Differentiation
Reverse Transcriptase Polymerase Chain Reaction
Transgenic Mice
122 Citations (Scopus)

High-Throughput Identification of Proteins and Unanticipated Sequence Modifications Using a Mass-Based Alignment Algorithm for MS/MS de Novo Sequencing Results

Searle, B. O., Dasari, S., Turner, M., Reddy, A. P., Choi, D., Wilmarth, P., McCormack, A. L., David, L. & Nagalla, S. B., Apr 15 2004, In : Analytical Chemistry. 76, 8, p. 2220-2230 11 p.

Research output: Contribution to journalArticle

Throughput
Proteins
Amino Acids
Peptides
Mass spectrometry
30 Citations (Scopus)

Laser light-scattering evidence for an altered association of βB1-crystallin deamidated in the connecting peptide

Harms, M. J., Wilmarth, P., Kapfer, D. M., Steel, E. A., David, L., Bächinger, H. P. & Lampi, K., Mar 2004, In : Protein Science. 13, 3, p. 678-686 9 p.

Research output: Contribution to journalArticle

Crystallins
C-Peptide
Light scattering
Lasers
Light
31 Citations (Scopus)

Proteomic and sequence analysis of chicken lens crystallins reveals alternate splicing and translational forms of βB2 and βA2 crystallins

Wilmarth, P., Taube, J. R., Riviere, M. A., Duncan, M. K. & David, L., Aug 2004, In : Investigative Ophthalmology and Visual Science. 45, 8, p. 2705-2715 11 p.

Research output: Contribution to journalArticle

Crystallins
Alternative Splicing
varespladib methyl
Proteomics
Lenses
354 Citations (Scopus)

Ribosomal protein L23 activates p53 by inhibiting MDM2 function in response to ribosomal perturbation but not to translation inhibition

Dai, M., Zeng, S. X., Jin, Y., Sun, X-X., David, L. & Lu, H., Sep 2004, In : Molecular and Cellular Biology. 24, 17, p. 7654-7668 15 p.

Research output: Contribution to journalArticle

Ribosomal Proteins
Polyribosomes
Ubiquitination
Dactinomycin
Ribosomes
6 Citations (Scopus)

Sequence and peptide map of guinea pig aquaporin 0

Han, J., Little, M., David, L., Giblin, F. J. & Schey, K. L., Mar 26 2004, In : Molecular Vision. 10, p. 215-222 8 p.

Research output: Contribution to journalArticle

Guinea Pigs
Post Translational Protein Processing
Peptides
Cataract
Phosphorylation
112 Citations (Scopus)

Two-dimensional liquid chromatography study of the human whole saliva proteome

Wilmarth, P., Riviere, M. A., Rustvold, D. L., Lauten, J. D., Madden, T. E. & David, L., Sep 2004, In : Journal of Proteome Research. 3, 5, p. 1017-1023 7 p.

Research output: Contribution to journalArticle

Liquid chromatography
Proteome
Saliva
Liquid Chromatography
Proteins
2003
41 Citations (Scopus)

Nucleophosmin Interacts with and Inhibits the Catalytic Function of Eukaryotic Initiation Factor 2 Kinase PKR

Pang, Q., Christianson, T. A., Koretsky, T., Carlson, H., David, L., Keeble, W., Faulkner, G. R., Speckhart, A. & Bagby, G. C., Oct 24 2003, In : Journal of Biological Chemistry. 278, 43, p. 41709-41717 9 p.

Research output: Contribution to journalArticle

Eukaryotic Initiation Factor-2
Phosphotransferases
Chemical activation
Cues
Fanconi Anemia
46 Citations (Scopus)

Proteome Analysis of Lens Epithelia, Fibers, and the HLE B-3 Cell Line

Wang-Su, S. T., McCormack, A. L., Yang, S., Hosler, M. R., Mixon, A., Riviere, M. A., Wilmarth, P., Andley, U. P., Garland, D., Li, H., David, L. & Wagner, B. J., Nov 2003, In : Investigative Ophthalmology and Visual Science. 44, 11, p. 4829-4836 8 p.

Research output: Contribution to journalArticle

Proteome
Lenses
Epithelium
Cell Line
Crystallins
2002
9 Citations (Scopus)

Altered patterns of phosphorylation in cultured mouse lenses during development of buthionine sulfoximine cataracts

Li, W., Calvin, H. I., David, L., Wu, K., McCormack, A. L., Zhu, G. P. & Joseph Fu, S. C., 2002, In : Experimental Eye Research. 75, 3, p. 335-346 12 p.

Research output: Contribution to journalArticle

Buthionine Sulfoximine
Crystallins
Cataract
Lenses
Phosphorylation
62 Citations (Scopus)

Deamidation, but not truncation, decreases the urea stability of a lens structural protein, βB1-crystallin

Kim, Y. H., Kapfer, D. M., Boekhorst, J., Lubsen, N. H., Bächinger, H. P., Shearer, T. T., David, L., Feix, J. B. & Lampi, K., Nov 26 2002, In : Biochemistry. 41, 47, p. 14076-14084 9 p.

Research output: Contribution to journalArticle

Crystallins
Denaturation
Urea
Lenses
Cataract
44 Citations (Scopus)

Decreased heat stability and increased chaperone requirement of modified human βB1-crystallins

Lampi, K., Kim, Y. H., Bächinger, H. P., Boswell, B. A., Lindner, R. A., Carver, J. A., Shearer, T. T., David, L. & Kapfer, D. M., 2002, In : Molecular Vision. 8, p. 359-366 8 p.

Research output: Contribution to journalArticle

Crystallins
Hot Temperature
Lenses
Molecular Chaperones
Protein Stability
9 Citations (Scopus)

General utility of the chicken βB1-crystallin promoter to drive protein expression in lens fiber cells of transgenic mice

Taube, J. R., Gao, C. Y., Ueda, Y., Zelenka, P. S., David, L. & Duncan, M. K., Aug 2002, In : Transgenic Research. 11, 4, p. 397-410 14 p.

Research output: Contribution to journalArticle

crystallins
fiber cells
Crystallins
Lens
Transgenic Mice
82 Citations (Scopus)
Crystallins
Proteomics
Lenses
Electrophoresis
Complementary DNA
151 Citations (Scopus)

Lens proteomics: The accumulation of crystallin modifications in the mouse lens with age

Ueda, Y., Duncan, M. K. & David, L., 2002, In : Investigative Ophthalmology and Visual Science. 43, 1, p. 205-215 11 p.

Research output: Contribution to journalArticle

Crystallins
Proteomics
Lenses
Cataract
Proteome
53 Citations (Scopus)
alpha-Crystallins
Endopeptidases
Lenses
Rats
Gels
2001
62 Citations (Scopus)

Deamidation of human βB1 alters the elongated structure of the dimer

Lampi, K., Oxford, J. T., Bachinger, H. P., Shearer, T. T., David, L. & Kapfer, D. M., 2001, In : Experimental Eye Research. 72, 3, p. 279-288 10 p.

Research output: Contribution to journalArticle

Gel Chromatography
Crystallins
Molecular Weight
Light
Protein Conformation
28 Citations (Scopus)

Proteolysis by m-calpain enhances in vitro light scattering by crystallins from human and bovine lenses

Shih, M., David, L., Lampi, K., Ma, H., Fukiage, C., Azuma, M. & Shearer, T. T., 2001, In : Current Eye Research. 22, 6, p. 458-469 12 p.

Research output: Contribution to journalArticle

Crystallins
Lenses
Proteolysis
Light
Hot Temperature
21 Citations (Scopus)

Purification and characterization of lens specific calpain (Lp82) from bovine lens

Ueda, Y., McCormack, A. L., Shearer, T. T. & David, L., 2001, In : Experimental Eye Research. 73, 5, p. 625-637 13 p.

Research output: Contribution to journalArticle

Lenses
Crystallins
Calpain
Phenylmethylsulfonyl Fluoride
Calcium
36 Citations (Scopus)

Resistance of human βB2-crystallin to in vivo modification

Zhang, Z., David, L., Smith, D. L. & Smith, J. B., 2001, In : Experimental Eye Research. 73, 2, p. 203-211 9 p.

Research output: Contribution to journalArticle

Crystallins
Solubility
Lenses
Water
Post Translational Protein Processing
2000
48 Citations (Scopus)

Contribution of calpain Lp82-induced proteolysis to experimental cataractogenesis in mice

Nakamura, Y., Fukiage, C., Shih, M., Ma, H., David, L., Azuma, M. & Shearer, T. T., 2000, In : Investigative Ophthalmology and Visual Science. 41, 6, p. 1460-1466 7 p.

Research output: Contribution to journalArticle

Lenses
Proteolysis
Crystallins
Cataract
Buthionine Sulfoximine
39 Citations (Scopus)

Isolation and identification of Prevotella tannerae from endodontic infections

Xia, T., Baumgartner, J. C. & David, L., Aug 2000, In : Oral Microbiology and Immunology. 15, 4, p. 273-275 3 p.

Research output: Contribution to journalArticle

Prevotella
Endodontics
Infection
rRNA Genes
Bacteria
1999
48 Citations (Scopus)

Lens cytoskeleton and transparency: A model

Clark, J. I., Matsushima, H., David, L. & Clark, J. M., Jun 1999, In : Eye. 13, 3 B, p. 417-424 8 p.

Research output: Contribution to journalArticle

Cytoskeleton
Lenses
Cytoskeletal Proteins
Vimentin
Tubulin
36 Citations (Scopus)

Modifications to rat lens major intrinsic protein in selenite-induced cataract

Schey, K. L., Fowler, J. G., Shearer, T. T. & David, L., 1999, In : Investigative Ophthalmology and Visual Science. 40, 3, p. 657-667 11 p.

Research output: Contribution to journalArticle

Selenious Acid
Cataract
Lenses
Tandem Mass Spectrometry
Protein C
19 Citations (Scopus)
Prevotella nigrescens
Prevotella intermedia
Sodium Dodecyl Sulfate
Polyacrylamide Gel Electrophoresis
Polymerase Chain Reaction
10 Citations (Scopus)

Survey for collagenase gene prtC in Porphyromonas gingivalis and Porphyromonas endodontalis isolated from endodontic infections

Odell, L. J., Baumgartner, J. C., Xia, T. & David, L., Aug 1999, In : Journal of Endodontics. 25, 8, p. 555-558 4 p.

Research output: Contribution to journalArticle

Porphyromonas endodontalis
Porphyromonas gingivalis
Endodontics
Collagenases
Infection
1998
142 Citations (Scopus)

Age-related changes in human lens crystallins identified by HPLC and mass spectrometry

Ma, Z., Hanson, S. R. A., Lampi, K., David, L., Smith, D. L. & Smith, J. B., Jul 1998, In : Experimental Eye Research. 67, 1, p. 21-30 10 p.

Research output: Contribution to journalArticle

Crystallins
Lenses
Mass Spectrometry
High Pressure Liquid Chromatography
Proteins
194 Citations (Scopus)

Age-related changes in human lens crystallins identified by two- dimensional electrophoresis and mass spectrometry

Lampi, K., Ma, Z., Hanson, S. R. A., Azuma, M., Shih, M., Shearer, T. T., Smith, D. L., Smith, J. B. & David, L., Jul 1998, In : Experimental Eye Research. 67, 1, p. 31-43 13 p.

Research output: Contribution to journalArticle

Crystallins
Lenses
Electrophoresis
Mass Spectrometry
Proteins
36 Citations (Scopus)

Cleavage of beta crystallins during maturation of bovine lens.

Shih, M., Lampi, K., Shearer, T. T. & David, L., Feb 27 1998, In : Molecular Vision. 4, p. 4 1 p.

Research output: Contribution to journalArticle

beta-Crystallins
Lenses
Crystallins
Peptide Hydrolases
Proline
9 Citations (Scopus)

Local microdomain structure in the terminal extensions of betaA3- and betaB2-crystallins.

Sergeev, Y. V., David, L., Chen, H. C., Hope, J. N. & Hejtmancik, J. F., Jun 18 1998, In : Molecular Vision. 4, p. 9 1 p.

Research output: Contribution to journalArticle

Crystallins
Baculoviridae
Proteolysis
Peptide Hydrolases
Sf9 Cells
1997
58 Citations (Scopus)

Activation of calpain in lens: A review and proposed mechanism

Azuma, M., Fukiage, C., David, L. & Shearer, T. T., Apr 1997, In : Experimental Eye Research. 64, 4, p. 529-538 10 p.

Research output: Contribution to journalArticle

Calpain
Lenses
Crystallins
Proteolysis
Caseins
12 Citations (Scopus)

Changes in calpain II mRNA in young rat lens during maturation and cataract formation

Ma, H., Shih, M., Throneberg, D. B., David, L. & Shearer, T. T., Mar 1997, In : Experimental Eye Research. 64, 3, p. 437-445 9 p.

Research output: Contribution to journalArticle

Calpain
Cataract
Lenses
Messenger RNA
Crystallins

Changes in rat lens calpastatin mrna during aging

Ma, H., Taytor, M., Mizuno, T., Shih, M., David, L. & Shearer, T. T., 1997, In : Investigative Ophthalmology and Visual Science. 38, 4

Research output: Contribution to journalArticle

Lenses
Messenger RNA
Calpain
RNA
calpastatin
1 Citation (Scopus)
Crystallins
Lenses
Complementary DNA
Mass Spectrometry
Amino Acid Sequence
Crystallins
Lenses
Calpain
Automatic Data Processing
Human Activities
Crystallins
Lenses
Peptides
varespladib methyl
Cataract
59 Citations (Scopus)

Loss of cytoskeletal proteins and lens cell opacification in the selenite cataract model

Matsushima, H., David, L., Hiraoka, T. & Clark, J. I., Mar 1997, In : Experimental Eye Research. 64, 3, p. 387-395 9 p.

Research output: Contribution to journalArticle

Selenious Acid
Cytoskeletal Proteins
Cataract
Lenses
Crystallins
33 Citations (Scopus)
Prevotella nigrescens
Prevotella intermedia
Endodontics
Infection
Bacteria
152 Citations (Scopus)

Sequence analysis of βA3, βB3, and βA4 crystallins completes the identification of the major proteins in young human lens

Lampi, K., Ma, Z., Shih, M., Shearer, T. T., Smith, J. B., Smith, D. L. & David, L., 1997, In : Journal of Biological Chemistry. 272, 4, p. 2268-2275 8 p.

Research output: Contribution to journalArticle

Crystallins
Lenses
Sequence Analysis
Amino Acids
Proteins
1996

Analysis of proteins during early stage selenite cataract & cataract prevention in rats

Matsushima, H., Clark, J. I., David, L. & Hiraoka, T., Feb 15 1996, In : Investigative Ophthalmology and Visual Science. 37, 3

Research output: Contribution to journalArticle

Selenious Acid
Cataract
Injections
Crystallins
Proteins

Calpain II mRNA expression in young rat lens is relatively high and dynamic

Shearer, T. T., Ma, H., Throneburg, D. B. & David, L., Feb 15 1996, In : Investigative Ophthalmology and Visual Science. 37, 3

Research output: Contribution to journalArticle

Calpain
Lenses
Messenger RNA
Cataract
Selenious Acid
21 Citations (Scopus)

Crystallins from rat lens are especially susceptible to calpain-induced light scattering compared to other species

Shearer, T. T., Shih, M., Mizuno, T. & David, L., Aug 1996, In : Current Eye Research. 15, 8, p. 860-868 9 p.

Research output: Contribution to journalArticle

Crystallins
Calpain
Lenses
Light
Proteolysis

Crystallins vary in their tendency to precipitate after proteolysis

Mizuno, T., Shih, M., David, L. & Shearer, T. T., Feb 15 1996, In : Investigative Ophthalmology and Visual Science. 37, 3

Research output: Contribution to journalArticle

Crystallins
Proteolysis
Lenses
Calpain
Cataract

Human βB1-crystallin is partially degraded at its N-terminal extension during lens maturation

David, L., Lampi, K., Lund, A. L. & Smith, J. B., Feb 15 1996, In : Investigative Ophthalmology and Visual Science. 37, 3

Research output: Contribution to journalArticle

Crystallins
Lenses
Complementary DNA
Water
Amino Acid Sequence

Quantitative analysis of calpain ii mrna in rat tissues

Ma, H., Shih, M., Thronebera, D. B., David, L. & Shearer, T. T., 1996, In : FASEB Journal. 10, 6

Research output: Contribution to journalArticle

calpain
Calpain
Lens
Lenses
quantitative analysis
Crystallins
Lenses
Amino Acids
Complementary DNA
Chickens
60 Citations (Scopus)

The sequence of human βB1 -crystallin cDNA allows mass spectrometric detection of βBl protein missing portions of its N-terminal extension

David, L., Lampi, K., Lund, A. L. & Smith, J. B., Feb 23 1996, In : Journal of Biological Chemistry. 271, 8, p. 4273-4279 7 p.

Research output: Contribution to journalArticle

Crystallins
Lenses
Complementary DNA
Amino Acids
Proteins
1995
17 Citations (Scopus)
Crystallins
Calcium Ionophores
Cataract
Lenses
Ionophores
35 Citations (Scopus)

Precipitation of crystallins from young rat lens by endogenous calpain

Shearer, T. T., Shih, M., Azuma, M. & David, L., 1995, In : Experimental Eye Research. 61, 2, p. 141-150 10 p.

Research output: Contribution to journalArticle

Crystallins
Calpain
Lenses
Proteolysis
Peptides