• 5967 Citations
  • 43 h-Index
1982 …2020
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Research Output 1982 2019

  • 5967 Citations
  • 43 h-Index
  • 186 Article
  • 1 Chapter
  • 1 Conference contribution
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Article
2019

Identification, Quantification, and System Analysis of Protein N-ε Lysine Methylation in Anucleate Blood Platelets

Rocheleau, A. D., Melrose, A. R., Cunliffe, J. M., Klimek, J., Babur, O., Tassi Yunga, S., Ngo, A. T. P., Pang, J., David, L., McCarty, O. & Aslan, J., Jan 1 2019, In : Proteomics. 1900001.

Research output: Contribution to journalArticle

Methylation
Platelets
Systems Analysis
Lysine
Identification (control systems)

Identification of PKCα-dependent phosphoproteins in mouse retina

Wakeham, C. M., Wilmarth, P., Cunliffe, J. M., Klimek, J. E., Ren, G., David, L. & Morgans, C., Aug 30 2019, In : Journal of Proteomics. 206, 103423.

Research output: Contribution to journalArticle

Protein Kinase C-alpha
Phosphoproteins
Retina
Phosphorylation
Cell Physiological Phenomena
4 Citations (Scopus)

Proteome-transcriptome analysis and proteome remodeling in mouse lens epithelium and fibers

Zhao, Y., Wilmarth, P., Cheng, C., Limi, S., Fowler, V. M., Zheng, D., David, L. & Cvekl, A., Feb 1 2019, In : Experimental Eye Research. 179, p. 32-46 15 p.

Research output: Contribution to journalArticle

Gene Expression Profiling
Proteome
Lenses
Epithelium
Proteins

Structure of the gene therapy vector, adeno-associated virus with its cell receptor, AAVR

Meyer, N. L., Hu, G., Davulcu, O., Xie, Q., Noble, A. J., Yoshioka, C., Gingerich, D. S., Trzynka, A., David, L., Stagg, S. M. & Chapman, M., May 22 2019, In : eLife. 8

Research output: Contribution to journalArticle

Open Access
Gene therapy
Dependovirus
Viruses
Genetic Therapy
Electron Microscope Tomography
2018
1 Citation (Scopus)
Angiogenic Proteins
Retinal Vessels
Proteomics
Endothelial Cells
Pharmaceutical Preparations
4 Citations (Scopus)

Anticancer Pyrroloquinazoline LBL1 Targets Nuclear Lamins

Li, B. X., Chen, J., Chao, B., David, L. & Xiao, X., May 18 2018, In : ACS Chemical Biology. 13, 5, p. 1380-1387 8 p.

Research output: Contribution to journalArticle

Lamins
Intermediate Filament Proteins
Lamin Type A
Cytoskeletal Proteins
Actin Cytoskeleton
2 Citations (Scopus)

Biomechanical rigidity and quantitative proteomics analysis of segmental regions of the trabecular meshwork at physiologic and elevated pressures

Vranka, J., Staverosky, J., Reddy, A. P., Wilmarth, P., David, L., Acott, T., Russell, P. & Raghunathan, V. K., Jan 1 2018, In : Investigative Ophthalmology and Visual Science. 59, 1, p. 246-259 14 p.

Research output: Contribution to journalArticle

Trabecular Meshwork
Proteomics
Pressure
Elastic Modulus
Extracellular Matrix Proteins
2 Citations (Scopus)

Combining Chemical Genetics with Proximity-Dependent Labeling Reveals Cellular Targets of Poly(ADP-ribose) Polymerase 14 (PARP14)

Carter-O'Connell, I., Vermehren-Schmaedick, A., Jin, H., Morgan, R. K., David, L. & Cohen, M., Oct 19 2018, In : ACS Chemical Biology. 13, 10, p. 2841-2848 8 p.

Research output: Contribution to journalArticle

Poly(ADP-ribose) Polymerases
Labeling
Adenosine Diphosphate
NAD
Proteins
4 Citations (Scopus)

Coordinated responses to individual tumor antigens by IgG antibody and CD8+ T cells following cancer vaccination

Hulett, T. W., Jensen, S. M., Wilmarth, P., Reddy, A. P., Ballesteros-Merino, C., Afentoulis, M. E., Dubay, C., David, L. & Fox, B. A., Apr 5 2018, In : Journal for ImmunoTherapy of Cancer. 6, 1, 27.

Research output: Contribution to journalArticle

Neoplasm Antigens
Vaccination
Immunoglobulin G
T-Lymphocytes
Antibodies

Data Descriptor: Mass spectrometry quantitation of proteins from small pools of developing auditory and vestibular cells

Krey, J. F., Scheffer, D. I., Choi, D., Reddy, A., David, L., Corey, D. P. & Barr-Gillespie, P., Jul 17 2018, In : Scientific data. 5, 180128.

Research output: Contribution to journalArticle

Mass Spectrometry
Descriptors
Digital differential analyzers
Mass spectrometry
Cells
3 Citations (Scopus)

ELMOD1 stimulates ARF6-GTP hydrolysis to stabilize apical structures in developing vestibular hair cells

Krey, J. F., Dumont, R. A., Wilmarth, P., David, L., Johnson, K. R. & Barr-Gillespie, P., Jan 24 2018, In : Journal of Neuroscience. 38, 4, p. 843-857 15 p.

Research output: Contribution to journalArticle

Vestibular Hair Cells
Guanosine Triphosphate
Hydrolysis
ADP-Ribosylation Factors
Saccule and Utricle
Lacrimal Apparatus
Nociception
Denervation
Tears
Menthol
5 Citations (Scopus)

MHC class I loaded ligands from breast cancer cell lines: A potential HLA-I-typed antigen collection

Rozanov, D., Rozanov, N. D., Chiotti, K. E., Reddy, A., Wilmarth, P., David, L., Cha, S. W., Woo, S., Pevzner, P., Bafna, V., Burrows, G. G., Rantala, J. K., Levin, T., Anur, P., Johnson-Camacho, K., Tabatabaei, S., Munson, D. J., Bruno, T. C., Slansky, J. E., Kappler, J. W. & 9 others, Hirano, N., Boegel, S., Fox, B. A., Egelston, C., Simons, D. L., Jimenez, G., Lee, P. P., Gray, J. & Spellman, P., Mar 30 2018, In : Journal of Proteomics. 176, p. 13-23 11 p.

Research output: Contribution to journalArticle

Cells
Breast Neoplasms
Ligands
Cell Line
Peptides
3 Citations (Scopus)

Platelet procoagulant phenotype is modulated by a p38-MK2 axis that regulates RTN4/Nogo proximal to the endoplasmic reticulum: utility of pathway analysis

Babur, O., Ngo, A. T. P., Rigg, R. A., Pang, J., Rub, Z. T., Buchanan, A. E., Mitrugno, A., David, L., McCarty, O., Demir, E. & Aslan, J., May 1 2018, In : American journal of physiology. Cell physiology. 314, 5, p. C603-C615

Research output: Contribution to journalArticle

Endoplasmic Reticulum
Blood Platelets
Phenotype
Hemostatics
Systems Biology
2017
17 Citations (Scopus)

Extended multiplexing of tandem mass tags (TMT) labeling reveals age and high fat diet specific proteome changes in mouse epididymal adipose tissue

Plubell, D. L., Wilmarth, P., Zhao, Y., Fenton, A. M., Minnier, J., Reddy, A. P., Klimek, J., Yang, X., David, L. & Pamir, N., May 1 2017, In : Molecular and Cellular Proteomics. 16, 5, p. 873-890 18 p.

Research output: Contribution to journalArticle

High Fat Diet
Proteome
Nutrition
Multiplexing
Labeling
11 Citations (Scopus)
Hemodynamics
Endocardium
Confocal Microscopy
Electron Scanning Microscopy
Proteomics
4 Citations (Scopus)
Myofibrils
Myocardium
Hemodynamics
Proteomics
Renin-Angiotensin System
3 Citations (Scopus)

Persulfide Formation Mediates Cysteine and Homocysteine Biosynthesis in Methanosarcina acetivorans

Rauch, B. J., Klimek, J., David, L. & Perona, J. J., Feb 28 2017, In : Biochemistry. 56, 8, p. 1051-1061 11 p.

Research output: Contribution to journalArticle

Methanosarcina
Biosynthesis
Homocysteine
RNA, Transfer, Cys
Cysteine
14 Citations (Scopus)

Proteomic analysis of the bovine and human ciliary zonule

De Maria, A., Wilmarth, P., David, L. & Bassnett, S., Jan 1 2017, In : Investigative Ophthalmology and Visual Science. 58, 1, p. 573-585 13 p.

Research output: Contribution to journalArticle

Proteomics
Proteins
Mass Spectrometry
Ectopia Lentis
High Pressure Liquid Chromatography
3 Citations (Scopus)
Epithelial-Mesenchymal Transition
Heat-Shock Proteins
Proteomics
Lenses
Glutathione
3 Citations (Scopus)

The zebrafish as a model system for analyzing mammalian and native α-crystallin promoter function

Posner, M., Murray, K. L., McDonald, M. S., Eighinger, H., Andrew, B., Drossman, A., Haley, Z., Nussbaum, J., David, L. & Lampi, K., Jan 1 2017, In : PeerJ. 2017, 11, 4093.

Research output: Contribution to journalArticle

crystallins
Crystallins
Zebrafish
Danio rerio
promoter regions
2016
3 Citations (Scopus)

Cyanide and the human brain: perspectives from a model of food (cassava) poisoning

Tshala-Katumbay, D., Ngombe, N. N., Okitundu, D., David, L., Westaway, S., Boivin, M. J., Mumba, N. D. & Banea, J. P., Aug 1 2016, In : Annals of the New York Academy of Sciences. 1378, 1, p. 50-57 8 p.

Research output: Contribution to journalArticle

Manihot
Foodborne Diseases
Cyanides
Brain
Toxicity
1 Citation (Scopus)

Differences in solution dynamics between lens β-crystallin homodimers and heterodimers probed by hydrogen-deuterium exchange and deamidation

Lampi, K., Murray, M. R., Peterson, M. P., Eng, B. S., Yue, E., Clark, A. R., Barbar, E. & David, L., Jan 1 2016, In : Biochimica et Biophysica Acta - General Subjects. 1860, 1, p. 304-314 11 p.

Research output: Contribution to journalArticle

Crystallins
Deuterium
Lenses
Hydrogen
Dimers
5 Citations (Scopus)

Evidence that the Rhodopsin Kinase (GRK1) N-Terminus and the Transducin Gα C-Terminus Interact with the Same "hydrophobic Patch" on Rhodopsin TM5

Jones Brunette, A. M., Sinha, A., David, L. & Farrens, D., Jun 7 2016, In : Biochemistry. 55, 22, p. 3123-3135 13 p.

Research output: Contribution to journalArticle

G-Protein-Coupled Receptor Kinase 1
Transducin
Rhodopsin
Phosphotransferases
G-Protein-Coupled Receptors
6 Citations (Scopus)

γ-Crystallins of the chicken lens: Remnants of an ancient vertebrate gene family in birds

Chen, Y., Sagar, V., Len, H. S., Peterson, K., Fan, J., Mishra, S., Mcmurtry, J., Wilmarth, P., David, L. & Wistow, G., 2016, (Accepted/In press) In : FEBS Journal.

Research output: Contribution to journalArticle

Crystallins
Birds
Lenses
Vertebrates
Chickens
2015
14 Citations (Scopus)

A novel, stable, aqueous Glucagon formulation using Ferulic acid as an Excipient

Bakhtiani, P. A., Caputo, N., Castle, J., El Youssef, J., Carroll, J. M., David, L., Roberts, C. & Kenneth, W., Jan 1 2015, In : Journal of diabetes science and technology. 9, 1, p. 17-23 7 p.

Research output: Contribution to journalArticle

ferulic acid
Excipients
Glucagon
Acids
Agglomeration
33 Citations (Scopus)

Coordinate regulation of residual bone marrow function by paracrine trafficking of AML exosomes

Huan, J., Hornick, N. I., Goloviznina, N. A., Kamimae-Lanning, A. N., David, L., Wilmarth, P., Mori, M. T., Chevillet, J. R., Narla, A., Roberts, C., Loriaux, M., Chang, B. & Kurre, P., Jun 25 2015, (Accepted/In press) In : Leukemia.

Research output: Contribution to journalArticle

Exosomes
Hematopoietic Stem Cells
Acute Myeloid Leukemia
Bone Marrow
Exosome Multienzyme Ribonuclease Complex
34 Citations (Scopus)

Cotranslational Stabilization of Sec62/63 within the ER Sec61 Translocon Is Controlled by Distinct Substrate-Driven Translocation Events

Conti, B. J., Devaraneni, P. K., Yang, Z., David, L. & Skach, W., Apr 16 2015, In : Molecular Cell. 58, 2, p. 269-283 15 p.

Research output: Contribution to journalArticle

Membranes
Peptides
Lipid Bilayers
Cytosol
Proteins
1 Citation (Scopus)

Data detailing the platelet acetyl-lysine proteome

Aslan, J., David, L. & McCarty, O., Dec 1 2015, In : Data in Brief. 5, p. 368-371 4 p.

Research output: Contribution to journalArticle

regulation
lack
3 Citations (Scopus)

Determination of Histidine pKa Values in the Propeptides of Furin and Proprotein Convertase 1/3 Using Histidine Hydrogen-Deuterium Exchange Mass Spectrometry

Elferich, J., Williamson, D. M., David, L. & Shinde, U., Aug 4 2015, In : Analytical Chemistry. 87, 15, p. 7909-7917 9 p.

Research output: Contribution to journalArticle

Proprotein Convertase 1
Furin
Deuterium
Histidine
Mass spectrometry
9 Citations (Scopus)

Hair-bundle proteomes of avian and mammalian inner-ear utricles

Wilmarth, P., Krey, J. F., Shin, J. B., Choi, D., David, L. & Barr-Gillespie, P., Dec 8 2015, In : Scientific data. 2, 150074.

Research output: Contribution to journalArticle

Bundle
Proteins
Mouse
Peptides
Rats
27 Citations (Scopus)

Identifying Family-Member-Specific Targets of Mono-ARTDs by Using a Chemical Genetics Approach

Carter-O'Connell, I., Jin, H., Morgan, R. K., Zaja, R., David, L., Ahel, I. & Cohen, M., Jul 22 2015, (Accepted/In press) In : Cell Reports.

Research output: Contribution to journalArticle

NAD
Catalytic Domain
Adenosine Diphosphate
ADP Ribose Transferases
Adenosine Diphosphate Ribose
7 Citations (Scopus)

Lysine acetyltransfer supports platelet function

Aslan, J., Rigg, R. A., Nowak, M. S., Loren, C. P., Baker-Groberg, S. M., Pang, J., David, L. & McCarty, O., Oct 1 2015, In : Journal of Thrombosis and Haemostasis. 13, 10, p. 1908-1917 10 p.

Research output: Contribution to journalArticle

Lysine
Blood Platelets
Actins
Acetylation
Proteins
5 Citations (Scopus)

Role for Rab10 in methamphetamine-induced behavior

Vanderwerf, S. M., Buck, D. C., Wilmarth, P., Sears, L. M., David, L., Morton, D. & Neve, K., Aug 20 2015, In : PLoS One. 10, 8, e0136167.

Research output: Contribution to journalArticle

Methamphetamine
receptors
rats
Membranes
Rats
10 Citations (Scopus)

Separating myoblast differentiation from muscle cell fusion using IGF-I and the p38 MAP kinase inhibitor SB202190

Gardner, S., Gross, S. M., David, L., Klimek, J. E. & Rotwein, P., Sep 1 2015, In : American Journal of Physiology - Cell Physiology. 309, 7, p. C491-C500

Research output: Contribution to journalArticle

Cell Fusion
Myoblasts
p38 Mitogen-Activated Protein Kinases
Insulin-Like Growth Factor I
Muscle Cells
2 Citations (Scopus)

Solution-phase crosstalk and regulatory interactions between multipotent adult progenitor cells and peripheral blood mononuclear cells

Burrows, G. G., Hof, W. VT., Reddy, A. P., Wilmarth, P., David, L., Raber, A., Bogaerts, A., Timmerman, L., Pinxteren, J., Roobrouck, V. D., Deans, R. J. & Maziarz, R., Dec 1 2015, In : Stem cells translational medicine. 4, 12, p. 1436-1449 14 p.

Research output: Contribution to journalArticle

Blood Cells
Stem Cells
Physiological Stress
Proteins
Cyclin D1
2014
51 Citations (Scopus)

Accurate label-free protein quantitation with high- and low-resolution mass spectrometers

Krey, J. F., Wilmarth, P., Shin, J. B., Klimek, J., Sherman, N. E., Jeffery, E. D., Choi, D., David, L. & Barr-Gillespie, P., Feb 7 2014, In : Journal of Proteome Research. 13, 2, p. 1034-1044 11 p.

Research output: Contribution to journalArticle

Mass spectrometers
Labels
Ions
Proteins
Tandem Mass Spectrometry
9 Citations (Scopus)

Biochemical stabilization of glucagon at alkaline pH

Caputo, N., Jackson, M. A., Castle, J., El Youssef, J., Bakhtiani, P. A., Bergstrom, C. P., Carroll, J. M., Breen, M. E., Leonard, G. L., David, L., Roberts, C. & Ward, W. K., 2014, In : Diabetes Technology and Therapeutics. 16, 11, p. 747-758 12 p.

Research output: Contribution to journalArticle

Glucagon
Insulin Infusion Systems
Curcumin
Excipients
Albumins
16 Citations (Scopus)

Correlation of actin crosslinker and capper expression levels with stereocilia growth phases

Avenarius, M. R., Saylor, K. W., Lundeberg, M. R., Wilmarth, P., Shin, J. B., Spinelli, K. J., Pagana, J. M., Andrade, L., Kachar, B., Choi, D., David, L. & Barr-Gillespie, P., Feb 2014, In : Molecular and Cellular Proteomics. 13, 2, p. 606-620 15 p.

Research output: Contribution to journalArticle

Stereocilia
Actins
Cochlea
Growth
Mass spectrometry
49 Citations (Scopus)

Engineering the substrate specificity of ADP-ribosyltransferases for identifying direct protein targets

Carter-O'Connell, I., Jin, H., Morgan, R. K., David, L. & Cohen, M., Apr 9 2014, In : Journal of the American Chemical Society. 136, 14, p. 5201-5204 4 p.

Research output: Contribution to journalArticle

ADP Ribose Transferases
Administrative data processing
Substrate Specificity
NAD
Proteins
19 Citations (Scopus)

Glutaredoxin 2 (Grx2) gene deletion induces early onset of age-dependent cataracts in mice

Wu, H., Yu, Y., David, L., Ho, Y. S. & Lou, M. F., Dec 26 2014, In : Journal of Biological Chemistry. 289, 52, p. 36125-36139 15 p.

Research output: Contribution to journalArticle

Glutaredoxins
Gene Deletion
Age of Onset
Cataract
Genes
42 Citations (Scopus)
Crystallins
Cataract
Lenses
Post Translational Protein Processing
Amides
31 Citations (Scopus)

Metabolic Reprogramming during Purine Stress in the Protozoan Pathogen Leishmania donovani

Martin, J. L., Yates, P., Soysa, R., Alfaro, J. F., Yang, F., Burnum-Johnson, K. E., Petyuk, V. A., Weitz, K. K., Camp, D. G., Smith, R. D., Wilmarth, P., David, L., Ramasamy, G., Myler, P. J. & Carter, N., 2014, In : PLoS Pathogens. 10, 2, e1003938.

Research output: Contribution to journalArticle

Leishmania donovani
Parasites
Starvation
Proteome
purine
26 Citations (Scopus)
Tumors
Carrier Proteins
Chemical activation
Enzymes
Neoplasms
8 Citations (Scopus)

Nascent proteomes in peripheral blood mononuclear cells as a novel source for biomarker discovery in human stroke

Bian, F., Simon, R. P., Li, Y., David, L., Wainwright, J., Hall, C. L., Frankel, M. & Zhou, A., 2014, In : Stroke. 45, 4, p. 1177-1179 3 p.

Research output: Contribution to journalArticle

Proteome
Blood Cells
Biomarkers
Stroke
Proteomics
4 Citations (Scopus)

Newborn mouse lens proteome and its alteration by lysine 6 mutant ubiquitin

Shang, F., Wilmarth, P., Chang, M. L., Liu, K., David, L., Caceres, M. A., Wawrousek, E. & Taylor, A., Mar 7 2014, In : Journal of Proteome Research. 13, 3, p. 1177-1189 13 p.

Research output: Contribution to journalArticle

Proteome
Ubiquitin
Lenses
Lysine
Crystallins
2013
8 Citations (Scopus)

Carbamoylation correlates of cyanate neuropathy and cyanide poisoning: Relevance to the biomarkers of cassava cyanogenesis and motor system toxicity

Kimani, S., Moterroso, V., Lasarev, M., Kipruto, S., Bukachi, F., Maitai, C., David, L. & Tshala-Katumbay, D., 2013, In : SpringerPlus. 2, 1, p. 1-8 8 p.

Research output: Contribution to journalArticle

Cyanates
Manihot
Cyanides
Sulfur Amino Acids
Poisoning
10 Citations (Scopus)
Semaphorin-3A
Heat-Shock Proteins
Autoantibodies
Chaperonin 60
Ocular Paraneoplastic Syndromes
4 Citations (Scopus)

Diagnostic and therapeutic potential of tetanus toxin-derivatives in neurological diseases

Kassa, R., Monterroso, V., David, L. & Tshala-Katumbay, D., Nov 2013, In : Journal of Molecular Neuroscience. 51, 3, p. 788-791 4 p.

Research output: Contribution to journalArticle

Tetanus Toxin
Motor Neurons
Mass Spectrometry
Blood-Nerve Barrier
Fluorescence
16 Citations (Scopus)

Dissection of the human multipotent adult progenitor cell secretome by proteomic analysis

Burrows, G. G., Van't Hof, W., Newell, L., Reddy, A., Wilmarth, P., David, L., Raber, A., Bogaerts, A., Pinxteren, J., Deans, R. J. & Maziarz, R., Oct 2013, In : Stem cells translational medicine. 2, 10, p. 745-757 13 p.

Research output: Contribution to journalArticle

Proteomics
Dissection
Stem Cells
Extracellular Matrix Proteins
Intercellular Signaling Peptides and Proteins