Kelly Monk

Professor

  • 2103 Citations
  • 23 h-Index
20022019

Research output per year

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Research Output

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Article
2019

Myelinating Schwann cells ensheath multiple axons in the absence of E3 ligase component Fbxw7

Harty, B. L., Coelho, F., Pease-Raissi, S. E., Mogha, A., Ackerman, S. D., Herbert, A. L., Gereau, R. W., Golden, J. P., Lyons, D. A., Chan, J. R. & Monk, K. R., Dec 1 2019, In : Nature communications. 10, 1, 2976.

Research output: Contribution to journalArticle

Open Access
3 Scopus citations
2018

Deletion of tsc2 in nociceptors reduces target innervation, ion channel expression, and sensitivity to heat

Carlin, D., Golden, J. P., Mogha, A., Samineni, V. K., Monk, K. R., Gereau, R. W. & Cavalli, V., Mar 1 2018, In : eNeuro. 5, 2, e0436-17.2018.

Research output: Contribution to journalArticle

2 Scopus citations

GPR56/ADG RG1 regulates development and maintenance of peripheral myelin

Ackerman, S. D., Luo, R., Poitelon, Y., Mogha, A., Harty, B. L., D'Rozario, M., Sanchez, N. E., Lakkaraju, A. K. K., Gamble, P., Li, J., Qu, J., MacEwan, M. R., Ray, W. Z., Aguzzi, A., Feltri, M. L., Piao, X. & Monk, K. R., Mar 1 2018, In : Journal of Experimental Medicine. 215, 3, p. 941-961 21 p.

Research output: Contribution to journalArticle

15 Scopus citations

Microglial transglutaminase-2 drives myelination and myelin repair via GPR56/ADGRG1 in oligodendrocyte precursor cells

Giera, S., Luo, R., Ying, Y., Ackerman, S. D., Jeong, S. J., Stoveken, H. M., Folts, C. J., Welsh, C. A., Tall, G. G., Stevens, B., Monk, K. R. & Piao, X., May 29 2018, In : eLife. 7, e33385.

Research output: Contribution to journalArticle

23 Scopus citations

Mutations in dock1 disrupt early Schwann cell development

Cunningham, R. L., Herbert, A. L., Harty, B. L., Ackerman, S. D. & Monk, K. R., Aug 8 2018, In : Neural Development. 13, 1, 17.

Research output: Contribution to journalArticle

1 Scopus citations
2017

Analysis of myelinated axon formation in zebrafish

D'Rozario, M., Monk, K. & Petersen, S. C., Jan 1 2017, In : Methods in Cell Biology. 138, p. 383-414 32 p.

Research output: Contribution to journalArticle

10 Scopus citations

Dynein/dynactin is necessary for anterograde transport of Mbp mRNA in oligodendrocytes and for myelination in vivo

Herbert, A. L., Fu, M. M., Drerup, C. M., Gray, R. S., Harty, B. L., Ackerman, S. D., O'Reilly-Pol, T., Johnson, S. L., Nechiporuk, A., Barres, B. A. & Monk, K., Oct 24 2017, In : Proceedings of the National Academy of Sciences of the United States of America. 114, 43, p. E9153-E9162

Research output: Contribution to journalArticle

12 Scopus citations

Laminin 211 inhibits protein kinase A in Schwann cells to modulate neuregulin 1 type III-driven myelination

Ghidinelli, M., Poitelon, Y., Shin, Y. K., Ameroso, D., Williamson, C., Ferri, C., Pellegatta, M., Espino, K., Mogha, A., Monk, K., Podini, P., Taveggia, C., Nave, K. A., Wrabetz, L., Park, H. T. & Feltri, M. L., Jun 21 2017, In : PLoS Biology. 15, 6, e2001408.

Research output: Contribution to journalArticle

14 Scopus citations

Regulation of mitochondria-dynactin interaction and mitochondrial retrograde transport in axons

Drerup, C. M., Herbert, A. L., Monk, K. R. & Nechiporuk, A. V., Apr 17 2017, In : eLife. 6, e22234.

Research output: Contribution to journalArticle

10 Scopus citations

Whole genome sequencing-based mapping and candidate identification of mutations from fixed zebrafish tissue

Sanchez, N. E., Harty, B. L., O'Reilly-Pol, T., Ackerman, S. D., Herbert, A. L., Holmgren, M., Johnson, S. L., Gray, R. S. & Monk, K. R., Oct 1 2017, In : G3: Genes, Genomes, Genetics. 7, 10, p. 3415-3425 11 p.

Research output: Contribution to journalArticle

2 Scopus citations
2016

Gpr126/Adgrg6 has Schwann cell autonomous and nonautonomous functions in peripheral nerve injury and repair

Mogha, A., Harty, B. L., Carlin, D., Joseph, J., Sanchez, N. E., Suter, U., Piao, X., Cavalli, V. & Monk, K. R., Dec 7 2016, In : Journal of Neuroscience. 36, 49, p. 12351-12367 17 p.

Research output: Contribution to journalArticle

23 Scopus citations

Structural Basis for Regulation of GPR56/ADGRG1 by Its Alternatively Spliced Extracellular Domains

Salzman, G. S., Ackerman, S. D., Ding, C., Koide, A., Leon, K., Luo, R., Stoveken, H. M., Fernandez, C. G., Tall, G. G., Piao, X., Monk, K., Koide, S. & Araç, D., Sep 21 2016, In : Neuron. 91, 6, p. 1292-1304 13 p.

Research output: Contribution to journalArticle

28 Scopus citations

The prion protein is an agonistic ligand of the G protein-coupled receptor Adgrg6

Küffer, A., Lakkaraju, A. K. K., Mogha, A., Petersen, S. C., Airich, K., Doucerain, C., Marpakwar, R., Bakirci, P., Senatore, A., Monnard, A., Schiavi, C., Nuvolone, M., Grosshans, B., Hornemann, S., Bassilana, F., Monk, K. R. & Aguzzi, A., Aug 8 2016, In : Nature. 536, 7617, p. 464-468 5 p.

Research output: Contribution to journalArticle

81 Scopus citations
2015

Adhesion G protein-coupled receptors: From in vitro pharmacology to in vivo mechanisms

Monk, K. R., Hamann, J., Langenhan, T., Nijmeijer, S., Schöneberg, T. & Liebscher, I., Sep 1 2015, In : Molecular pharmacology. 88, 3, p. 617-623 7 p.

Research output: Contribution to journalArticle

27 Scopus citations

Defining the gene repertoire and spatiotemporal expression profiles of adhesion G protein-coupled receptors in zebrafish

Harty, B. L., Krishnan, A., Sanchez, N. E., Schiöth, H. B. & Monk, K. R., Feb 8 2015, In : BMC Genomics. 16, 1, 59.

Research output: Contribution to journalArticle

19 Scopus citations

Gpr126/Adgrg6 deletion in cartilage models idiopathic scoliosis and pectus excavatum in mice

Karner, C. M., Long, F., Solnica-Krezel, L., Monk, K. R. & Gray, R. S., Aug 1 2015, In : Human molecular genetics. 24, 15, p. 4365-4373 9 p.

Research output: Contribution to journalArticle

33 Scopus citations

International union of basic and clinical pharmacology. XCIV. adhesion G protein-coupled receptors

Hamann, J., Aust, G., Araç, D., Engel, F. B., Formstone, C., Fredriksson, R., Hall, R. A., Harty, B. L., Kirchhoff, C., Knapp, B., Krishnan, A., Liebscher, I., Lin, H. H., Martinelli, D. C., Monk, K. R., Peeters, M. C., Piao, X., Prömel, S., Schöneberg, T., Schwartz, T. W. & 9 others, Singer, K., Stacey, M., Ushkaryov, Y. A., Vallon, M., Wolfrum, U., Wright, M. W., Xu, L., Langenhan, T. & Schiöth, H. B., Feb 23 2015, In : Pharmacological Reviews. 67, 2, p. 338-367 30 p.

Research output: Contribution to journalArticle

162 Scopus citations

Model organisms in G protein-coupled receptor research

Langenhan, T., Barr, M. M., Bruchas, M. R., Ewer, J., Griffith, L. C., Maiellaro, I., Taghert, P. H., White, B. H. & Monk, K. R., Sep 1 2015, In : Molecular pharmacology. 88, 3, p. 596-603 8 p.

Research output: Contribution to journalArticle

9 Scopus citations

Tethered agonists: A new mechanism underlying adhesion G protein-coupled receptor activation

Schöneberg, T., Liebscher, I., Luo, R., Monk, K. R. & Piao, X., Sep 11 2015, In : Journal of Receptors and Signal Transduction. 35, 3, p. 220-223 4 p.

Research output: Contribution to journalArticle

7 Scopus citations

The Adhesion GPCR GPR126 Has Distinct, Domain-Dependent Functions in Schwann Cell Development Mediated by Interaction with Laminin-211

Petersen, S. C., Luo, R., Liebscher, I., Giera, S., Jeong, S. J., Mogha, A., Ghidinelli, M., Feltri, M. L., Schöneberg, T., Piao, X. & Monk, K. R., Feb 18 2015, In : Neuron. 85, 4, p. 755-769 15 p.

Research output: Contribution to journalArticle

107 Scopus citations

The adhesion GPCR Gpr56 regulates oligodendrocyte development via interactions with Gα12/13 and RhoA

Ackerman, S. D., Garcia, C., Piao, X., Gutmann, D. H. & Monk, K. R., Jan 21 2015, In : Nature communications. 6, 6122.

Research output: Contribution to journalArticle

59 Scopus citations

The adhesion G protein-coupled receptor GPR56 is a cell-autonomous regulator of oligodendrocyte development

Giera, S., Deng, Y., Luo, R., Ackerman, S. D., Mogha, A., Monk, K. R., Ying, Y., Jeong, S. J., Makinodan, M., Bialas, A. R., Chang, B. S., Stevens, B., Corfas, G. & Piao, X., Jan 21 2015, In : Nature communications. 6, 6121.

Research output: Contribution to journalArticle

55 Scopus citations
2014

A Tethered Agonist within the Ectodomain Activates the Adhesion G Protein-Coupled Receptors GPR126 and GPR133

Liebscher, I., Schön, J., Petersen, S. C., Fischer, L., Auerbach, N., Demberg, L. M., Mogha, A., Cöster, M., Simon, K. U., Rothemund, S., Monk, K. R. & Schöneberg, T., Dec 24 2014, In : Cell Reports. 9, 6, p. 2018-2026 9 p.

Research output: Contribution to journalArticle

106 Scopus citations

New functions and signaling mechanisms for the class of adhesion G protein-coupled receptors

Liebscher, I., Ackley, B., Araç, D., Ariestanti, D. M., Aust, G., Bae, B. I., Bista, B. R., Bridges, J. P., Duman, J. G., Engel, F. B., Giera, S., Goffinet, A. M., Hall, R. A., Hamann, J., Hartmann, N., Lin, H. H., Liu, M., Luo, R., Mogha, A., Monk, K. R. & 12 others, Peeters, M. C., Prömel, S., Ressl, S., Schiöth, H. B., Sigoillot, S. M., Song, H., Talbot, W. S., Tall, G. G., White, J. P., Wolfrum, U., Xu, L. & Piao, X., Dec 1 2014, In : Annals of the New York Academy of Sciences. 1333, 1, p. 43-64 22 p.

Research output: Contribution to journalArticle

13 Scopus citations
2013

An anti-inflammatory nod-like receptor is required for microglia development

Shiau, C. E., Monk, K. R., Joo, W. & Talbot, W. S., Dec 12 2013, In : Cell Reports. 5, 5, p. 1342-1352 11 p.

Research output: Contribution to journalArticle

52 Scopus citations

Gpr126 functions in schwann cells to control differentiation and myelination via G-protein activation

Mogha, A., Benesh, A. E., Patra, C., Engel, F. B., Schöneberg, T., Liebscher, I. & Monk, K. R., Nov 15 2013, In : Journal of Neuroscience. 33, 46, p. 17976-17985 10 p.

Research output: Contribution to journalArticle

86 Scopus citations

Mutation of sec63 in zebrafish causes defects in myelinated axons and liver pathology

Monk, K. R., Voas, M. G., Franzini-Armstrong, C., Hakkinen, I. S. & Talbot, W. S., Jan 2013, In : DMM Disease Models and Mechanisms. 6, 1, p. 135-145 11 p.

Research output: Contribution to journalArticle

18 Scopus citations

Organ-specific function of adhesion G protein-coupled receptor GPR126 is domain-dependent

Patra, C., Van Amerongen, M. J., Ghosh, S., Ricciardi, F., Sajjad, A., Novoyatleva, T., Mogha, A., Monk, K. R., Mühlfeld, C. & Engel, F. B., Oct 15 2013, In : Proceedings of the National Academy of Sciences of the United States of America. 110, 42, p. 16898-16903 6 p.

Research output: Contribution to journalArticle

55 Scopus citations

The NF2 tumor suppressor regulates microtubule-based vesicle trafficking via a novel Rac, MLK and p38 SAPK pathway

Hennigan, R. F., Moon, C. A., Parysek, L. M., Monk, K. R., Morfini, G., Berth, S., Brady, S. & Ratner, N., Feb 28 2013, In : Oncogene. 32, 9, p. 1135-1143 9 p.

Research output: Contribution to journalArticle

14 Scopus citations
2012

Dissecting signaling and functions of adhesion G protein-coupled receptors

Araç, D., Aust, G., Calebiro, D., Engel, F. B., Formstone, C., Goffinet, A., Hamann, J., Kittel, R. J., Liebscher, I., Lin, H. H., Monk, K. R., Petrenko, A., Piao, X., Prömel, S., Schiöth, H. B., Schwartz, T. W., Stacey, M., Ushkaryov, Y. A., Wobus, M., Wolfrum, U. & 2 others, Xu, L. & Langenhan, T., Dec 2012, In : Annals of the New York Academy of Sciences. 1276, 1, p. 1-25 25 p.

Research output: Contribution to journalArticle

28 Scopus citations
2011

Gpr126 is essential for peripheral nerve development and myelination in mammals

Monk, K. R., Oshima, K., Jörs, S., Heller, S. & Talbot, W. S., Jul 1 2011, In : Development. 138, 13, p. 2673-2680 8 p.

Research output: Contribution to journalArticle

117 Scopus citations
2009

A G protein-coupled receptor is essential for schwann cells to initiate myelination

Monk, K. R., Naylor, S. G., Glenn, T. D., Mercurio, S., Perlin, J. R., Dominguez, C., Moens, C. B. & Talbot, W. S., Sep 18 2009, In : Science. 325, 5946, p. 1402-1405 4 p.

Research output: Contribution to journalArticle

206 Scopus citations
2007

Mast cells can contribute to axon-glial dissociation and fibrosis in peripheral nerve

Monk, K. R., Wu, J., Williams, J. P., Finney, B. A., Fitzgerald, M. E., Filippi, M. D. & Ratner, N., Aug 1 2007, In : Neuron Glia Biology. 3, 3, p. 233-244 12 p.

Research output: Contribution to journalArticle

20 Scopus citations
2006

Perinatal epidermal growth factor receptor blockade prevents peripheral nerve disruption in a mouse model reminiscent of benign World Health Organization grade I neurofibroma

Wu, J., Crimmins, J. T., Monk, K. R., Williams, J. P., Fitzgerald, M. E., Tedesco, S. & Ratner, N., May 2006, In : American Journal of Pathology. 168, 5, p. 1686-1696 11 p.

Research output: Contribution to journalArticle

16 Scopus citations
2005

Role for the epidermal growth factor receptor in neurofibromatosis-related peripheral nerve tumorigenesis

Ling, B. C., Wu, J., Miller, S. J., Monk, K. R., Shamekh, R., Rizvi, T. A., Decourten-Myers, G., Vogel, K. S., Declue, J. E. & Ratner, N., Jan 1 2005, In : Cancer Cell. 7, 1, p. 65-75 11 p.

Research output: Contribution to journalArticle

99 Scopus citations
2003

Neurofibromin-deficient Schwann cells secrete a potent migratory stimulus for NF1+/- mast cells

Yang, F. C., Ingram, D. A., Chen, S., Hingtgen, C. M., Ratner, N., Monk, K. R., Clegg, T., White, H., Mead, L., Wenning, M. J., Williams, D. A., Kapur, R., Atkinson, S. J. & Clapp, D. W., Dec 2003, In : Journal of Clinical Investigation. 112, 12, p. 1851-1861 11 p.

Research output: Contribution to journalArticle

153 Scopus citations
2002

The xenoestrogen bisphenol a induces inappropriate androgen receptor activation and mitogenesis in prostatic adenocarcinoma cells

Wetherill, Y. B., Petre, C. E., Monk, K. R., Puga, A. & Knudsen, K. E., May 1 2002, In : Molecular cancer therapeutics. 1, 7, p. 515-524 10 p.

Research output: Contribution to journalArticle

154 Scopus citations