John Muschler

Research Associate Professor

  • 3303 SW Bond Avenue, CH13B, Portland OR 97239

  • 2205 Citations
  • 21 h-Index
1989 …2019
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Research Output 1989 2019

  • 2205 Citations
  • 21 h-Index
  • 30 Article
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Article
2019

3D-Imaging of Whole Neuronal and Vascular Networks of the Human Dental Pulp via CLARITY and Light Sheet Microscopy

França, C. M., Riggers, R., Muschler, J., Widbiller, M., Lococo, P. M., Diogenes, A. & Bertassoni, L., Dec 1 2019, In : Scientific Reports. 9, 1, 10860.

Research output: Contribution to journalArticle

Open Access
Dental Pulp
Acrylamide
Hydrogel
Blood Vessels
Microscopy
7 Citations (Scopus)

Modeling Tumor Phenotypes In Vitro with Three-Dimensional Bioprinting

Langer, E. M., Allen-Petersen, B. L., King, S. M., Kendsersky, N. D., Turnidge, M. A., Kuziel, G. M., Riggers, R., Samatham, R., Amery, T. S., Jacques, S., Sheppard, B., Korkola, J., Muschler, J., Thibault, G., Chang, Y. H., Gray, J., Presnell, S. C., Nguyen, D. G. & Sears, R., Jan 15 2019, In : Cell Reports. 26, 3, p. 608-623.e6

Research output: Contribution to journalArticle

Bioprinting
Tumors
Tissue
Phenotype
Scaffolds
2017
10 Citations (Scopus)

Far-Red and Near-Infrared Seminaphthofluorophores for Targeted Pancreatic Cancer Imaging

Wang, L., Barth, C. W., Sibrian-Vazquez, M., Escobedo, J. O., Lowry, M., Muschler, J., Li, H., Gibbs, S. & Strongin, R. M., Jan 31 2017, In : ACS Omega. 2, 1, p. 154-163 10 p.

Research output: Contribution to journalArticle

Infrared radiation
Fluorescent Dyes
Imaging techniques
Tissue
Molecular Probes
2014
10 Citations (Scopus)

Endocytic trafficking of laminin is controlled by dystroglycan and is disrupted in cancers

Leonoudakis, D., Huang, G., Akhavan, A., Fata, J. E., Singh, M., Gray, J. & Muschler, J., 2014, In : Journal of Cell Science. 127, 22, p. 4894-4903 10 p.

Research output: Contribution to journalArticle

Dystroglycans
Laminin
Neoplasms
Basement Membrane
Laminin Receptors
2012
26 Citations (Scopus)

Loss of cell-surface laminin anchoring promotes tumor growth and is associated with poor clinical outcomes

Akhavan, A., Griffith, O. L., Soroceanu, L., Leonoudakis, D., Luciani-Torres, M. G., Daemen, A., Gray, J. & Muschler, J., May 15 2012, In : Cancer Research. 72, 10, p. 2578-2588 11 p.

Research output: Contribution to journalArticle

Laminin
Growth
Neoplasms
Brain Neoplasms
Disease Progression
2010
82 Citations (Scopus)

Cell-matrix interactions in mammary gland development and breast cancer.

Muschler, J. & Streuli, C. H., Oct 1 2010, In : Cold Spring Harbor perspectives in biology. 2, 10

Research output: Contribution to journalArticle

Human Mammary Glands
Cell Communication
Breast
Breast Neoplasms
Tissue
21 Citations (Scopus)

Dystroglycan controls signaling of multiple hormones through modulation of STAT5 activity

Leonoudakis, D., Singh, M., Mohajer, R., Mohajer, P., Fata, J. E., Campbell, K. P. & Muschler, J., Nov 1 2010, In : Journal of Cell Science. 123, 21, p. 3683-3692 10 p.

Research output: Contribution to journalArticle

STAT5 Transcription Factor
Dystroglycans
Hormones
Laminin
Basement Membrane
70 Citations (Scopus)

Raf-induced MMP9 disrupts tissue architecture of human breast cells in three-dimensional culture and is necessary for tumor growth in vivo

Beliveau, A., Mott, J. D., Lo, A., Chen, E. I., Koller, A. A., Yaswen, P., Muschler, J. & Bissell, M. J., Dec 15 2010, In : Genes and Development. 24, 24, p. 2800-2811 12 p.

Research output: Contribution to journalArticle

Breast
Growth
Mitogen-Activated Protein Kinase Kinases
Laminin
Neoplasms
2009
77 Citations (Scopus)

Sustained activation of STAT5 is essential for chromatin remodeling and maintenance of mammary-specifi c function

Xu, R., Nelson, C. M., Muschler, J., Veiseh, M., Vonderhaar, B. K. & Bissell, M. J., Jan 12 2009, In : Journal of Cell Biology. 184, 1, p. 57-66 10 p.

Research output: Contribution to journalArticle

STAT Transcription Factors
STAT5 Transcription Factor
Chromatin Assembly and Disassembly
Laminin
Breast
2008
22 Citations (Scopus)

Nuclear translocation of β-dystroglycan reveals a distinctive trafficking pattern of autoproteolyzed mucins

Oppizzi, M. L., Akhavan, A., Singh, M., Fata, J. E. & Muschler, J., 2008, In : Traffic. 9, 12, p. 2063-2072 10 p.

Research output: Contribution to journalArticle

Dystroglycans
Mucins
Agrin
Enteropeptidase
Ligands
37 Citations (Scopus)

SEA domain proteolysis determines the functional composition of dystroglycan

Akhavan, A., Crivelli, S. N., Singh, M., Lingappa, V. R. & Muschler, J., Feb 2008, In : FASEB Journal. 22, 2, p. 612-621 10 p.

Research output: Contribution to journalArticle

Dystroglycans
Proteolysis
proteolysis
muscular dystrophy
Chemical analysis
2007
18 Citations (Scopus)

Regulation of clusterin expression in mammary epithelial cells

Itahana, Y., Piens, M., Sumida, T., Fong, S., Muschler, J. & Desprez, P. Y., Mar 10 2007, In : Experimental Cell Research. 313, 5, p. 943-951 9 p.

Research output: Contribution to journalArticle

Clusterin
Breast
Epithelial Cells
Human Mammary Glands
Up-Regulation
2006
73 Citations (Scopus)

Dystroglycan loss disrupts polarity and β-casein induction in mammary epithelial cells by perturbing laminin anchoring

Weir, M. L., Oppizzi, M. L., Henry, M. D., Onishi, A., Campbell, K. P., Bissell, M. J. & Muschler, J., Oct 1 2006, In : Journal of Cell Science. 119, 19, p. 4047-4058 12 p.

Research output: Contribution to journalArticle

Dystroglycans
Laminin
Caseins
Breast
Epithelial Cells
2004
216 Citations (Scopus)

Molecular recognition by LARGE is essential for expression of functional dystroglycan

Kanagawa, M., Saito, F., Kunz, S., Yoshida-Moriguchi, T., Barresi, R., Kobayashi, Y. M., Muschler, J., Dumanski, J. P., Michele, D. E., Oldstone, M. B. A. & Campbell, K. P., Jun 25 2004, In : Cell. 117, 7, p. 953-964 12 p.

Research output: Contribution to journalArticle

Dystroglycans
Molecular recognition
Glycosylation
Muscle
Mucins
81 Citations (Scopus)

Proteolytic enzymes and altered glycosylation modulate dystroglycan function in carcinoma cells

Singh, J., Itahana, Y., Knight-Krajewski, S., Kanagawa, M., Campbell, K. P., Bissell, M. J. & Muschler, J., Sep 1 2004, In : Cancer Research. 64, 17, p. 6152-6159 8 p.

Research output: Contribution to journalArticle

Dystroglycans
Glycosylation
Peptide Hydrolases
Carcinoma
Furin
2003
51 Citations (Scopus)

CpG content affects gene silencing in mice: evidence from novel transgenes.

Chevalier-Mariette, C., Henry, I., Montfort, L., Capgras, S., Forlani, S., Muschler, J. & Nicolas, J. F., 2003, In : Genome Biology. 4, 9

Research output: Contribution to journalArticle

methylation
Gene Silencing
gene silencing
Transgenes
transgenes
18 Citations (Scopus)

Dystroglycan: Emerging roles in mammary gland function

Weir, M. L. & Muschler, J., Oct 2003, In : Journal of Mammary Gland Biology and Neoplasia. 8, 4, p. 409-419 11 p.

Research output: Contribution to journalArticle

Dystroglycans
Human Mammary Glands
Basement Membrane
Dystrophin
Muscular Dystrophies
2002
120 Citations (Scopus)

A role for dystroglycan in epithelial polarization: Loss of function in breast tumor cells

Muschler, J., Levy, D., Boudreau, R., Henry, M., Campbell, K. & Bissell, M. J., Dec 1 2002, In : Cancer Research. 62, 23, p. 7102-7109 8 p.

Research output: Contribution to journalArticle

Dystroglycans
Breast Neoplasms
Basement Membrane
Aptitude
Breast
69 Citations (Scopus)

Order and disorder: The role of extracellular matrix in epithelial cancer

Radisky, D., Muschler, J. & Bissell, M. J., 2002, In : Cancer Investigation. 20, 1, p. 139-153 15 p.

Research output: Contribution to journalArticle

Glandular and Epithelial Neoplasms
Neoplasm Antigens
Extracellular Matrix
Signal Transduction
Neoplasms
1999
97 Citations (Scopus)

Division of labor among the α6β4 integrin, β1 integrins, and an E3 laminin receptor to signal morphogenesis and β-casein expression in mammary epithelial cells

Muschler, J., Lochter, A., Roskelley, C. D., Yurchenco, P. & Bissell, M. J., Sep 1999, In : Molecular Biology of the Cell. 10, 9, p. 2817-2828 12 p.

Research output: Contribution to journalArticle

Laminin Receptors
Laminin
Caseins
Morphogenesis
Integrins
6 Citations (Scopus)

LagoZ et LagZ, deux genes appauvris en dinucleotides CpG derives du gene LacZ pour l'etude des controles epigenetiques

Translated title of the contribution: LagoZ and LagZ, two genes derived from the LacZ gene to study epigeneticsHenry, I., Forlani, S., Vaillant, S., Muschler, J., Choulika, A. & Nicolas, J. F., Dec 1999, In : Comptes Rendus de l'Academie des Sciences - Serie III. 322, 12, p. 1061-1070 10 p.

Research output: Contribution to journalArticle

Lac Operon
Epigenomics
Genes
gene
Histone Deacetylases
1998
1 Citation (Scopus)

Immunopurification of a sarcomeric junctional protein complex containing GAPDH

McDonald, K. A., Muschler, J. & Horwitz, A. F., Sep 15 1998, In : Experimental Cell Research. 243, 2, p. 305-318 14 p.

Research output: Contribution to journalArticle

Glyceraldehyde-3-Phosphate Dehydrogenases
Antigens
Proteins
Actinin
Focal Adhesions
1997
494 Citations (Scopus)

Matrix metalloproteinase stromelysin-1 triggers a cascade of molecular alterations that leads to stable epithelial-to-mesenchymal conversion and a premalignant phenotype in mammary epithelial cells

Lochter, A., Galosy, S., Muschler, J., Freedman, N., Werb, Z. & Bissell, M. J., Dec 29 1997, In : Journal of Cell Biology. 139, 7, p. 1861-1872 12 p.

Research output: Contribution to journalArticle

Matrix Metalloproteinase 3
Matrix Metalloproteinase 1
Breast
Matrix Metalloproteinases
Epithelial Cells
1996
168 Citations (Scopus)

Integrin α subunit ratios, cytoplasmic domains, and growth factor synergy regulate muscle proliferation and differentiation

Sastry, S. K., Lakonishok, M., Thomas, D. A., Muschler, J. & Horwitz, A. F., Apr 1996, In : Journal of Cell Biology. 133, 1, p. 169-184 16 p.

Research output: Contribution to journalArticle

Myoblasts
Integrins
Intercellular Signaling Peptides and Proteins
Muscles
Serum
92 Citations (Scopus)

The extracellular matrix in epithelial biology: Shared molecules and common themes in distant phyla

Ashkenas, J., Muschler, J. & Bissell, M. J., Dec 15 1996, In : Developmental Biology. 180, 2, p. 433-444 12 p.

Research output: Contribution to journalArticle

Extracellular Matrix
1992
109 Citations (Scopus)

Developmentally regulated expression of α6 integrin in avian embryos

Bronner-Fraser, M., Artinger, M., Muschler, J. & Horwitz, A. F., May 1992, In : Development. 115, 1, p. 197-211 15 p.

Research output: Contribution to journalArticle

Neural Tube
Integrins
Embryonic Structures
Mesonephros
Neuroepithelial Cells
9 Citations (Scopus)

LBL, a novel, developmentally regulated, laminin-binding lectin

Bao, Z. Z., Muschler, J. & Horwitz, A. F., Mar 5 1992, In : Journal of Biological Chemistry. 267, 7, p. 4974-4980 7 p.

Research output: Contribution to journalArticle

Laminin
Lectins
Integrins
Proteins
Galactosides
60 Citations (Scopus)

The alpha;5β1 integrin associates with a dystrophin-containing lattice during muscle development

Lakonishok, M., Muschler, J. & Horwitz, A. F., 1992, In : Developmental Biology. 152, 2, p. 203-207 5 p.

Research output: Contribution to journalArticle

Dystrophin
Muscle Development
Integrins
Focal Adhesions
Myofibrils
1991
64 Citations (Scopus)

Down-regulation of the chicken α5β1 integrin fibronectin receptor during development

Muschler, J. & Horwitz, A. F., Sep 1991, In : Development. 113, 1, p. 327-337 11 p.

Research output: Contribution to journalArticle

Integrin alpha5beta1
Integrins
Chickens
Down-Regulation
Embryonic Structures
1989
97 Citations (Scopus)

Integrin on developing and adult skeletal muscle

Bozyczko, D., Decker, C., Muschler, J. & Horwitz, A. F., 1989, In : Experimental Cell Research. 183, 1, p. 72-91 20 p.

Research output: Contribution to journalArticle

Integrins
Skeletal Muscle
Muscles
Talin
Vinculin