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Hiroyuki Nakai

Professor, Molecular and Medical Genetics, Molecular Microbiology and Immunology, School of Medicine Distinguished Professor in Molecular Medicine

  • 5712 Citations
  • 32 h-Index
1989 …2019

Research output per year

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Projects

Gene Therapy for Diabetes

Grompe, M. & Nakai, H.

Project: Research project

Mechanistic Studies of AAP and Capsid Assembly of AAV Vectors

Nakai, H.

Project: Research project

In vivo targeting of diabetes-relevant human cell types with rAAV vectors

Grompe, M., Kay, M. & Nakai, H.

National Institutes of Health

9/30/14 → 6/30/19

Project: Research project

    • AAV capsid functions, immune evasion and neuronal targeting in mice and NHP

    Nakai, H.

    National Institutes of Health

    7/1/14 → 4/30/20

    Project: Research project

    • Vector and host cellular biology in AAV vector transduction in vivo

    Nakai, H.

    National Institutes of Health

    4/1/07 → 7/31/14

    Project: Research project

    • Research Output

    • 5712 Citations
    • 32 h-Index
    • 71 Article
    • 4 Letter
    • 2 Comment/debate
    • 1 Review article

    Codon-Optimization of Wild-Type Adeno-Associated Virus Capsid Sequences Enhances DNA Family Shuffling while Conserving Functionality

    Cabanes-Creus, M., Ginn, S. L., Amaya, A. K., Liao, S. H. Y., Westhaus, A., Hallwirth, C. V., Wilmott, P., Ward, J., Dilworth, K. L., Santilli, G., Rybicki, A., Nakai, H., Thrasher, A. J., Filip, A. C., Alexander, I. E. & Lisowski, L., Mar 15 2019, In : Molecular Therapy - Methods and Clinical Development. 12, p. 71-84 14 p.

    Research output: Contribution to journal › Article

    • 4 Scopus citations

    A quantitative dot blot assay for AAV titration and its use for functional assessment of the adeno-associated virus assembly-activating proteins

    Powers, J. M., Chang, X. L., Song, Z. & Nakai, H., Jun 12 2018, In : Journal of Visualized Experiments. 2018, 136, e56766.

    Research output: Contribution to journal › Article

    • Adeno-associated virus (AAV) assembly-activating protein is not an essential requirement for capsid assembly of AAV serotypes 4, 5, and 11

    Earley, L. F., Powers, J. M., Adachi, K., Baumgart, J. T., Meyer, N. L., Xie, Q., Chapman, M. & Nakai, H., 2017, In : Journal of Virology. 91, 3, e01980-16.

    Research output: Contribution to journal › Article

    • 30 Scopus citations

    Site-directed RNA repair of endogenous Mecp2 RNA in neurons

    Sinnamon, J. R., Kim, S. Y., Corson, G. M., Song, Z., Nakai, H., Adelman, J. & Mandel, G., Oct 31 2017, In : Proceedings of the National Academy of Sciences of the United States of America. 114, 44, p. E9395-E9402

    Research output: Contribution to journal › Article

    • 21 Scopus citations

    Engineering a gene silencing viral construct that targets the cat hypothalamus to induce permanent sterility: An update

    Dissen, G., Adachi, K., Lomniczi, A., Chatkupt, T., Davidson, B., Nakai, H. & Ojeda, S., 2016, (Accepted/In press) In : Reproduction in Domestic Animals.

    Research output: Contribution to journal › Article

    • 5 Scopus citations