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Hiroyuki Nakai

Professor, Molecular and Medical Genetics, Molecular Microbiology and Immunology, School of Medicine Distinguished Professor in Molecular Medicine

  • 5782 Citations
  • 32 h-Index
1989 …2020

Research output per year

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Projects

Gene Therapy for Diabetes

Grompe, M. & Nakai, H.

Project: Research project

Mechanistic Studies of AAP and Capsid Assembly of AAV Vectors

Nakai, H.

Project: Research project

In vivo targeting of diabetes-relevant human cell types with rAAV vectors

Grompe, M., Kay, M. & Nakai, H.

National Institutes of Health

9/30/14 → 6/30/19

Project: Research project

    • AAV capsid functions, immune evasion and neuronal targeting in mice and NHP

    Nakai, H.

    National Institutes of Health

    7/1/14 → 4/30/20

    Project: Research project

    • Vector and host cellular biology in AAV vector transduction in vivo

    Nakai, H.

    National Institutes of Health

    4/1/07 → 7/31/14

    Project: Research project

    • Research Output

    • 5782 Citations
    • 32 h-Index
    • 73 Article
    • 4 Letter
    • 2 Comment/debate
    • 1 Review article

    Adeno-associated virus-binding antibodies detected in cats living in the Northeastern United States lack neutralizing activity

    Adachi, K., Dissen, G. A., Lomniczi, A., Xie, Q., Ojeda, S. R. & Nakai, H., Dec 1 2020, In : Scientific Reports. 10, 1, 10073.

    Research output: Contribution to journal › Article

    Open Access

    • In Vivo Repair of a Protein Underlying a Neurological Disorder by Programmable RNA Editing

    Sinnamon, J. R., Kim, S. Y., Fisk, J. R., Song, Z., Nakai, H., Jeng, S., McWeeney, S. K. & Mandel, G., Jul 14 2020, In : Cell Reports. 32, 2, 107878.

    Research output: Contribution to journal › Article

    Open Access
    • 1 Scopus citations

    Codon-Optimization of Wild-Type Adeno-Associated Virus Capsid Sequences Enhances DNA Family Shuffling while Conserving Functionality

    Cabanes-Creus, M., Ginn, S. L., Amaya, A. K., Liao, S. H. Y., Westhaus, A., Hallwirth, C. V., Wilmott, P., Ward, J., Dilworth, K. L., Santilli, G., Rybicki, A., Nakai, H., Thrasher, A. J., Filip, A. C., Alexander, I. E. & Lisowski, L., Mar 15 2019, In : Molecular Therapy - Methods and Clinical Development. 12, p. 71-84 14 p.

    Research output: Contribution to journal › Article

    • 5 Scopus citations

    A quantitative dot blot assay for AAV titration and its use for functional assessment of the adeno-associated virus assembly-activating proteins

    Powers, J. M., Chang, X. L., Song, Z. & Nakai, H., Jun 12 2018, In : Journal of Visualized Experiments. 2018, 136, e56766.

    Research output: Contribution to journal › Article

    • Adeno-associated virus (AAV) assembly-activating protein is not an essential requirement for capsid assembly of AAV serotypes 4, 5, and 11

    Earley, L. F., Powers, J. M., Adachi, K., Baumgart, J. T., Meyer, N. L., Xie, Q., Chapman, M. S. & Nakai, H., 2017, In : Journal of virology. 91, 3, e01980-16.

    Research output: Contribution to journal › Article

    • 31 Scopus citations