David Morton

Professor

  • 1487 Citations
  • 23 h-Index
1983 …2019
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Research Output 1983 2019

  • 1487 Citations
  • 23 h-Index
  • 59 Article
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Article
2019

Deletion of a specific exon in the voltage-gated calcium channel gene cacophony disrupts locomotion in Drosophila larvae

Lembke, K. M., Law, A. D., Ahrar, J. & Morton, D., Jan 1 2019, In : Journal of Experimental Biology. 222, 1, jeb191106.

Research output: Contribution to journalArticle

calcium channels
locomotion
Calcium Channels
Locomotion
Drosophila
2017
4 Citations (Scopus)
Phosphorylation
Ubiquitination
Drosophila
Neurons
phosphorylation
1 Citation (Scopus)
Calcium Channels
Neurodegenerative Diseases
Drosophila
Amyotrophic Lateral Sclerosis
TDP-43 Proteinopathies
4 Citations (Scopus)

Restoration of motor defects caused by loss of drosophila TDP-43 by expression of the voltage-gated calcium channel, cacophony, in central neurons

Lembke, K. M., Scudder, C. & Morton, D., Sep 27 2017, In : Journal of Neuroscience. 37, 39, p. 9486-9497 12 p.

Research output: Contribution to journalArticle

Calcium Channels
Locomotion
Drosophila
Neuromuscular Junction
Motor Neurons
2016
53 Citations (Scopus)

Multifaceted biological insights from a draft genome sequence of the tobacco hornworm moth, Manduca sexta

Kanost, M. R., Arrese, E. L., Cao, X., Chen, Y. R., Chellapilla, S., Goldsmith, M. R., Grosse-Wilde, E., Heckel, D. G., Herndon, N., Jiang, H., Papanicolaou, A., Qu, J., Soulages, J. L., Vogel, H., Walters, J., Waterhouse, R. M., Ahn, S. J., Almeida, F. C., An, C., Aqrawi, P. & 94 others, Bretschneider, A., Bryant, W. B., Bucks, S., Chao, H., Chevignon, G., Christen, J. M., Clarke, D. F., Dittmer, N. T., Ferguson, L. C. F., Garavelou, S., Gordon, K. H. J., Gunaratna, R. T., Han, Y., Hauser, F., He, Y., Heidel-Fischer, H., Hirsh, A., Hu, Y., Jiang, H., Kalra, D., Klinner, C., König, C., Kovar, C., Kroll, A. R., Kuwar, S. S., Lee, S. L., Lehman, R., Li, K., Li, Z., Liang, H., Lovelace, S., Lu, Z., Mansfield, J. H., McCulloch, K. J., Mathew, T., Morton, B., Muzny, D. M., Neunemann, D., Ongeri, F., Pauchet, Y., Pu, L. L., Pyrousis, I., Rao, X. J., Redding, A., Roesel, C., Sanchez-Gracia, A., Schaack, S., Shukla, A., Tetreau, G., Wang, Y., Xiong, G. H., Traut, W., Walsh, T. K., Worley, K. C., Wu, D., Wu, W., Wu, Y. Q., Zhang, X., Zou, Z., Zucker, H., Briscoe, A. D., Burmester, T., Clem, R. J., Feyereisen, R., Grimmelikhuijzen, C. J. P., Hamodrakas, S. J., Hansson, B. S., Huguet, E., Jermiin, L. S., Lan, Q., Lehman, H. K., Lorenzen, M., Merzendorfer, H., Michalopoulos, I., Morton, D., Muthukrishnan, S., Oakeshott, J. G., Palmer, W., Park, Y., Passarelli, A. L., Rozas, J., Schwartz, L. M., Smith, W., Southgate, A., Vilcinskas, A., Vogt, R., Wang, P., Werren, J., Yu, X. Q., Zhou, J. J., Brown, S. J., Scherer, S. E., Richards, S. & Blissard, G. W., Sep 1 2016, In : Insect Biochemistry and Molecular Biology. 76, p. 118-147 30 p.

Research output: Contribution to journalArticle

Manduca
Tobacco
Moths
Manduca sexta
moths
2015
5 Citations (Scopus)

Role for Rab10 in methamphetamine-induced behavior

Vanderwerf, S. M., Buck, D. C., Wilmarth, P., Sears, L. M., David, L., Morton, D. & Neve, K., Aug 20 2015, In : PLoS One. 10, 8, e0136167.

Research output: Contribution to journalArticle

Methamphetamine
receptors
rats
Membranes
Rats
2014
16 Citations (Scopus)

Motor neuron expression of the voltage-gated calcium channel cacophony restores locomotion defects in a Drosophila, TDP-43 loss of function model of ALS

Chang, J. C., Hazelett, D. J., Stewart, J. A. & Morton, D., Oct 10 2014, In : Brain Research. 1584, p. 39-51 13 p.

Research output: Contribution to journalArticle

Amyotrophic Lateral Sclerosis
Motor Neurons
Calcium Channels
Locomotion
Drosophila
2013
29 Citations (Scopus)

Phosphodiesterase-8A binds to and regulates Raf-1 kinase

Brown, K. M., Day, J. P., Huston, E., Zimmermann, B., Hampel, K., Christian, F., Romano, D., Terhzaz, S., Lee, L. C. Y., Willis, M. J., Morton, D., Beavo, J. A., Shimizu-Albergine, M., Davies, S. A., Kolch, W., Houslay, M. D. & Baillie, G. S., Apr 16 2013, In : Proceedings of the National Academy of Sciences of the United States of America. 110, 16

Research output: Contribution to journalArticle

Proto-Oncogene Proteins c-raf
Phosphoric Diester Hydrolases
Phosphorylation
MAP Kinase Signaling System
Drosophila melanogaster
2012
33 Citations (Scopus)
Tars
High-Throughput Nucleotide Sequencing
DNA-Binding Proteins
Drosophila
Central Nervous System
2011
8 Citations (Scopus)

Behavioral responses to hypoxia and hyperoxia in Drosophila larvae molecular and neuronal sensors

Morton, D., Apr 2011, In : Fly. 5, 2, p. 119-125 7 p.

Research output: Contribution to journalArticle

hyperoxia
sensors (equipment)
hypoxia
Drosophila
oxygen
7 Citations (Scopus)

Drosophila gustatory preference behaviors require the atypical soluble guanylyl cyclases

Vermehren-Schmaedick, A., Scudder, C., Timmermans, W. & Morton, D., Jul 2011, In : Journal of Comparative Physiology A: Neuroethology, Sensory, Neural, and Behavioral Physiology. 197, 7, p. 717-727 11 p.

Research output: Contribution to journalArticle

preference behavior
guanylate cyclase
food choices
Drosophila
caffeine
11 Citations (Scopus)

Response properties of visual neurons in the turtle nucleus isthmi

Saha, D., Morton, D., Ariel, M. & Wessel, R., 2011, In : Journal of Comparative Physiology A: Neuroethology, Sensory, Neural, and Behavioral Physiology. 197, 2, p. 153-165 13 p.

Research output: Contribution to journalArticle

Turtles
Superior Colliculi
optics
turtle
turtles
2010
33 Citations (Scopus)

Behavioral responses to hypoxia in drosophila larvae are mediated by atypical soluble guanylyl cyclases

Vermehren-Schmaedick, A., Ainsley, J. A., Johnson, W. A., Davies, S. A. & Morton, D., Sep 2010, In : Genetics. 186, 1, p. 183-196 14 p.

Research output: Contribution to journalArticle

Drosophila
Larva
Neurons
Cyclic Nucleotide-Gated Cation Channels
Oxygen
6 Citations (Scopus)

Infertility and male mating behavior deficits associated with Pde1c in Drosophila melanogaster

Morton, D., Clemens-Grisham, R., Hazelett, D. J. & Vermehren-Schmaedick, A., Sep 2010, In : Genetics. 186, 1, p. 159-165 7 p.

Research output: Contribution to journalArticle

Male Infertility
Drosophila melanogaster
Infertility
Copulation
Cyclic Nucleotides
2009
145 Citations (Scopus)

Neurons Detect Increases and Decreases in Oxygen Levels Using Distinct Guanylate Cyclases

Zimmer, M., Gray, J. M., Pokala, N., Chang, A. J., Karow, D. S., Marletta, M. A., Hudson, M. L., Morton, D., Chronis, N. & Bargmann, C. I., Mar 26 2009, In : Neuron. 61, 6, p. 865-879 15 p.

Research output: Contribution to journalArticle

Guanylate Cyclase
Oxygen
Neurons
Sensory Receptor Cells
Psychological Adaptation
2008
13 Citations (Scopus)

Synaptic transmission in neurons that express the Drosophila atypical soluble guanylyl cyclases, Gyc-89Da and Gyc-89Db, is necessary for the successful completion of larval and adult ecdysis

Morton, D., Stewart, J. A., Langlais, K. K., Clemens-Grisham, R. A. & Vermehren, A., May 2008, In : Journal of Experimental Biology. 211, 10, p. 1645-1656 12 p.

Research output: Contribution to journalArticle

tetanus
Molting
guanylate cyclase
synaptic transmission
ecdysis
2007
5 Citations (Scopus)

Soluble guanylyl cyclases in invertebrates: Targets for NO and O2

Morton, D. & Vermehren, A., 2007, In : Advances in Experimental Biology. 1, p. 65-82 18 p.

Research output: Contribution to journalArticle

Guanylate Cyclase
Invertebrates
Oxygen sensors
Oxygen
Molecular oxygen
2006
24 Citations (Scopus)

Oxygen-sensitive guanylyl cyclases in insects and their potential roles in oxygen detection and in feeding behaviors

Vermehren, A., Langlais, K. K. & Morton, D., Apr 2006, In : Journal of Insect Physiology. 52, 4, p. 340-348 9 p.

Research output: Contribution to journalArticle

guanylate cyclase
Guanylate Cyclase
Feeding Behavior
feeding behavior
Insects
2005
13 Citations (Scopus)

Comparison of the properties of the five soluble guanylyl cyclase subunits in Drosophila melanogaster

Morton, D., Langlais, K. K., Stewart, J. A. & Vermehren, A., Apr 19 2005, In : Journal of Insect Science. 5, p. 1-10 10 p.

Research output: Contribution to journalArticle

guanylate cyclase
Drosophila melanogaster
peripheral nervous system
enzymes
central nervous system
2004
42 Citations (Scopus)

Atypical soluble guanylyl cyclases in Drosophila can function as molecular oxygen sensors

Morton, D., Dec 3 2004, In : Journal of Biological Chemistry. 279, 49, p. 50651-50653 3 p.

Research output: Contribution to journalArticle

Oxygen sensors
Molecular oxygen
Guanylate Cyclase
Drosophila
Oxygen
49 Citations (Scopus)

Invertebrates yield a plethora of atypical guanylyl cyclases

Morton, D., Apr 2004, In : Molecular Neurobiology. 29, 2, p. 97-115 19 p.

Research output: Contribution to journalArticle

Guanylate Cyclase
Invertebrates
Drosophila
Manduca
Nitric Oxide
19 Citations (Scopus)

Preliminary characterization of two atypical soluble guanylyl cyclases in the central and peripheral nervous system of Drosophila melanogaster

Langlais, K. K., Stewart, J. A. & Morton, D., Jun 2004, In : Journal of Experimental Biology. 207, 13, p. 2323-2338 16 p.

Research output: Contribution to journalArticle

guanylate cyclase
peripheral nervous system
Nitric Oxide Donors
Peripheral Nervous System
nitric oxide
2003
13 Citations (Scopus)

MsGC-II, a receptor guanylyl cyclase isolated from the CNS of Manduca sexta that is inhibited by calcium

Morton, D. & Nighorn, A., Jan 2003, In : Journal of Neurochemistry. 84, 2, p. 363-372 10 p.

Research output: Contribution to journalArticle

Guanylate Cyclase-Coupled Receptors
Manduca
Guanylate Cyclase
COS Cells
Calcium
17 Citations (Scopus)

MsGC-β3 forms active homodimers and inactive heterodimers with NO-sensitive soluble guanylyl cyclase subunits

Morton, D. & Anderson, E. J., Mar 2003, In : Journal of Experimental Biology. 206, 6, p. 937-947 11 p.

Research output: Contribution to journalArticle

guanylate cyclase
nitric oxide
enzyme activity
Manduca
Manduca sexta
2002
19 Citations (Scopus)

Cellular signaling in eclosion hormone action

Morton, D. & Simpson, P. J., 2002, In : Journal of Insect Physiology. 48, 1, p. 1-13 13 p.

Research output: Contribution to journalArticle

eclosion hormone
cell communication
guanylate cyclase
neuropeptides
Neuropeptides
25 Citations (Scopus)

Cyclic GMP regulation and function in insects

Morton, D. & Hudson, M. L., 2002, In : Advances in Insect Physiology. 29, p. 1-54 54 p.

Research output: Contribution to journalArticle

cyclic GMP
guanylate cyclase
insects
proteins
cGMP-dependent protein kinase
36 Citations (Scopus)

Nicotinic-acetylcholine receptors are functionally coupled to the nitric oxide/cGMP-pathway in insect neurons

Zayas, R. M., Qazi, S., Morton, D. & Trimmer, B. A., Oct 2002, In : Journal of Neurochemistry. 83, 2, p. 421-431 11 p.

Research output: Contribution to journalArticle

Nicotinic Receptors
Neurons
Insects
Nitric Oxide
Insect control
2001
21 Citations (Scopus)

The novel guanylyl cyclase MsGC-I is strongly expressed in higher-order neuropils in the brain of Manduca sexta

Nighorn, A., Simpson, P. J. & Morton, D., 2001, In : Journal of Experimental Biology. 204, 2, p. 305-314 10 p.

Research output: Contribution to journalArticle

Manduca
guanylate cyclase
Neuropil
Guanylate Cyclase
Manduca sexta
2000
8 Citations (Scopus)
Manduca
Abdominal Muscles
Cyclic GMP
Axons
Diaphragm
28 Citations (Scopus)

Neurons involved in nitric oxide-mediated cGMP signaling in the tobacco hornworm, Manduca sexta

Zayas, R. M., Qazi, S., Morton, D. & Trimmer, B. A., Apr 17 2000, In : Journal of Comparative Neurology. 419, 4, p. 422-438 17 p.

Research output: Contribution to journalArticle

Manduca
Cyclic GMP
Nitric Oxide
Neurons
Nitric Oxide Synthase
1999
44 Citations (Scopus)
Manduca
Guanylate Cyclase
Nitric Oxide
Amino Acids
Neurology
28 Citations (Scopus)

Identification of a novel guanylyl cyclase that is related to receptor guanylyl cyclases, but lacks extracellular and transmembrane domains

Simpson, P. J., Nighorn, A. & Morton, D., Feb 12 1999, In : Journal of Biological Chemistry. 274, 7, p. 4440-4446 7 p.

Research output: Contribution to journalArticle

Guanylate Cyclase-Coupled Receptors
Guanylate Cyclase
Nervous System
Manduca
Neurology
32 Citations (Scopus)

Soluble guanylyl cyclases in Caenorhabditis elegans: NO is not the answer [1]

Morton, D., Hudson, M. L., Waters, E. & O'Shea, M., Aug 12 1999, In : Current Biology. 9, 15

Research output: Contribution to journalArticle

guanylate cyclase
Caenorhabditis elegans
Soluble Guanylyl Cyclase
1998
16 Citations (Scopus)

Norepinephrine increases cyclic GMP levels in cerebellar cells from neuronal nitric oxide synthase knockout mice

Morton, D. & Bredt, D. S., Jul 1998, In : Journal of Neurochemistry. 71, 1, p. 440-443 4 p.

Research output: Contribution to journalArticle

Nitric Oxide Synthase Type I
Cyclic GMP
Knockout Mice
Norepinephrine
Neurology
103 Citations (Scopus)

The nitric oxide-cGMP pathway may mediate communication between sensory afferents and projection neurons in the antennal lobe of Manduca sexta

Nighorn, A., Gibson, N. J., Rivers, D. M., Hildebrand, J. G. & Morton, D., Sep 15 1998, In : Journal of Neuroscience. 18, 18, p. 7244-7255 12 p.

Research output: Contribution to journalArticle

Manduca
Afferent Neurons
Sensory Receptor Cells
Nitric Oxide Synthase
Nitric Oxide
1997
11 Citations (Scopus)
Hormones
Nervous System
4 Citations (Scopus)
Ecdysteroids
Manduca
ecdysteroids
Manduca sexta
Trachea
1996
9 Citations (Scopus)
Ecdysterone
Ecdysteroids
Manduca
ecdysterone
ecdysteroids
5 Citations (Scopus)

Expression of a developmentally regulated gene, Mng10, in identified neurosecretory cells in the CNS of Manduca sexta

Mészáros, M. & Morton, D., Jul 1996, In : Journal of Neurobiology. 30, 3, p. 349-358 10 p.

Research output: Contribution to journalArticle

Manduca
Nervous System
Neuropeptides
Genes
Neurons
15 Citations (Scopus)
Manduca
Epididymis
epididymis
Manduca sexta
Molting
24 Citations (Scopus)

Insect physiology: The emerging story of ecdysis

Hesterlee, S. & Morton, D., 1996, In : Current Biology. 6, 6, p. 648-650 3 p.

Research output: Contribution to journalArticle

Insect Hormones
insect physiology
insect hormones
insect behavior
Molting
18 Citations (Scopus)
Cyclic GMP
Neuropeptides
Molting
Manduca
Nerve Endings
11 Citations (Scopus)

Subtractive hybridization strategy using paramagnetic oligo(dT) beads and PCR

Mészáros, M. & Morton, D., Mar 1996, In : BioTechniques. 20, 3, p. 413-419 7 p.

Research output: Contribution to journalArticle

Manduca
Complementary DNA
Polymerase Chain Reaction
Messenger RNA
Tobacco
1995
17 Citations (Scopus)
eclosion hormone
Manduca
Inositol 1,4,5-Trisphosphate
Manduca sexta
Neurology
9 Citations (Scopus)
Manduca
Molting
Tobacco
Phosphoproteins
Cycloheximide
102 Citations (Scopus)

Remodeling of the insect nervous system

Levine, R. B., Morton, D. & Restifo, L. L., 1995, In : Current Opinion in Neurobiology. 5, 1, p. 28-35 8 p.

Research output: Contribution to journalArticle

Nervous System
Insects
Ecdysteroids
Neurogenesis
Cell Death
1994
11 Citations (Scopus)
Ecdysteroids
Manduca
Trachea
Molting
Genes
34 Citations (Scopus)

Spatiotemporal pattern of expression of tenascin-like molecules in a developing insect olfactory system

Krull, C. E., Morton, D., Faissner, A., Schachner, M. & Tolbert, L. P., 1994, In : Journal of Neurobiology. 25, 5, p. 515-534 20 p.

Research output: Contribution to journalArticle

Tenascin
Neuroglia
Insects
Axons
Neuropil
1992
41 Citations (Scopus)
Manduca
Nerve Tissue
Cyclic GMP
Arachidonic Acid
Metabolism
1991
40 Citations (Scopus)

Expression of an eclosion hormone gene in insect cells using baculovirus vectors

Eldridge, R., Horodyski, F. M., Morton, D., O'Reilly, D. R., Truman, J. W., Riddiford, L. M. & Miller, L. K., 1991, In : Insect Biochemistry. 21, 3, p. 341-351 11 p.

Research output: Contribution to journalArticle

eclosion hormone
Insect Genes
Baculoviridae
polypeptides
Genes