Daniel Streblow

Associate Professor

  • 4344 Citations
  • 36 h-Index
1978 …2019

Research output per year

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Research Output

Article

Additives for vaccine storage to improve thermal stability of adenoviruses from hours to months

Pelliccia, M., Andreozzi, P., Paulose, J., D'Alicarnasso, M., Cagno, V., Donalisio, M., Civra, A., Broeckel, R. M., Haese, N., Silva, P. J., Carney, R. P., Marjomäki, V., Streblow, D. N., Lembo, D., Stellacci, F., Vitelli, V. & Krol, S., Nov 30 2016, In : Nature communications. 7, 13520.

Research output: Contribution to journalArticle

19 Scopus citations

Animal models of chikungunya virus infection and disease

Haese, N. N., Broeckel, R. M., Hawman, D. W., Heise, M. T., Morrison, T. E. & Streblow, D. N., Dec 1 2016, In : Journal of Infectious Diseases. 214, p. S482-S487

Research output: Contribution to journalArticle

17 Scopus citations

A novel agonist of the trif pathway induces a cellular state refractory to replication of Zika, Chikungunya, and dengue viruses

Pryke, K. M., Abraham, J., Sali, T. M., Gall, B. J., Archer, I., Liu, A., Bambina, S., Baird, J., Gough, M., Chakhtoura, M., Haddad, E. K., Kirby, I. T., Nilsen, A., Streblow, D. N., Hirsch, A. J., Smith, J. L. & Defilippis, V. R., May 1 2017, In : mBio. 8, 3, e00452-17.

Research output: Contribution to journalArticle

19 Scopus citations

A novel human cytomegalovirus locus modulates cell type-specific outcomes of infection

Umashankar, M., Petrucelli, A., Cicchini, L., Caposio, P., Kreklywich, C. N., Rak, M., Bughio, F., Goldman, D. C., Hamlin, K. L., Nelson, J. A., Fleming, W. H., Streblow, D. N. & Goodrum, F., Dec 1 2011, In : PLoS pathogens. 7, 12, e1002444.

Research output: Contribution to journalArticle

80 Scopus citations

Characterization of a Novel Human-Specific STING Agonist that Elicits Antiviral Activity Against Emerging Alphaviruses

Sali, T. M., Pryke, K. M., Abraham, J., Liu, A., Archer, I., Broeckel, R., Staverosky, J., Smith, J. L., Al-Shammari, A., Amsler, L., Sheridan, K., Nilsen, A., Streblow, D. & De Filippis, V., 2015, In : PLoS Pathogens. 11, 12, e1005324.

Research output: Contribution to journalArticle

38 Scopus citations

Chikungunya viruses that escape monoclonal antibody therapy are clinically attenuated, stable, and not purified in mosquitoes

Pal, P., Fox, J. M., Hawman, D. W., Huang, Y. J. S., Messaoudi, I., Kreklywich, C., Denton, M., Legasse, A. W., Smith, P. P., Johnson, S., Axthelm, M. K., Vanlandingham, D. L., Streblow, D. N., Higgs, S., Morrison, T. E. & Diamond, M. S., 2014, In : Journal of virology. 88, 15, p. 8213-8226 14 p.

Research output: Contribution to journalArticle

35 Scopus citations

Chikungunya virus induces IPS-1-dependent innate immune activation and protein kinase R-independent translational shutoff

White, L. K., Sali, T., Alvarado, D., Gatti, E., Pierre, P., Streblow, D. & DeFilippis, V. R., Jan 1 2011, In : Journal of virology. 85, 1, p. 606-620 15 p.

Research output: Contribution to journalArticle

85 Scopus citations

Chikungunya Virus Infection Results in Higher and Persistent Viral Replication in Aged Rhesus Macaques Due to Defects in Anti-Viral Immunity

Messaoudi, I., Vomaske, J., Totonchy, T., Kreklywich, C. N., Haberthur, K., Springgay, L., Brien, J. D., Diamond, M. S., DeFilippis, V. R. & Streblow, D. N., Jul 2013, In : PLoS neglected tropical diseases. 7, 7, e2343.

Research output: Contribution to journalArticle

52 Scopus citations

Complex interplay of the UL136 isoforms balances cytomegalovirus replication and Latency

Caviness, K., Bughio, F., Crawford, L. B., Streblow, D. N., Nelson, J. A., Caposio, P. & Goodrum, F., Mar 1 2016, In : mBio. 7, 2, e01986-15.

Research output: Contribution to journalArticle

22 Scopus citations

Cross-Species Rhesus Cytomegalovirus Infection of Cynomolgus Macaques

Burwitz, B., Malouli, D., Bimber, B. N., Reed, J. S., Ventura, A. B., Hancock, M., Uebelhoer, L. S., Bhusari, A., Hammond, K. B., Espinosa Trethewy, R. G., Klug, A., Legasse, A. W., Axthelm, M., Nelson, J., Park, B., Streblow, D., Hansen, S., Picker, L., Frueh, K. & Sacha, J., Nov 1 2016, In : PLoS Pathogens. 12, 11, e1006014.

Research output: Contribution to journalArticle

16 Scopus citations

Cyclophilin A modulates processing of human immunodeficiency virus type 1 p55(Gag): Mechanism for antiviral effects of cyclosporin A

Streblow, D. N., Kitabwalla, M., Malkovsky, M. & Pauza, C. D., Jun 5 1998, In : Virology. 245, 2, p. 197-202 6 p.

Research output: Contribution to journalArticle

51 Scopus citations

Cytomegalovirus Accelerates Chronic Allograft Nephropathy in a Rat Renal Transplant Model With Associated Provocative Chemokine Profiles

Soule, J. L., Streblow, D. N., Andoh, T. F., Kreklywich, C. N. & Orloff, S. L., Dec 1 2006, In : Transplantation proceedings. 38, 10, p. 3214-3220 7 p.

Research output: Contribution to journalArticle

12 Scopus citations

Cytomegalovirus CC chemokine promotes immune cell migration

Vomaske, J., Denton, M., Kreklywich, C., Andoh, T., Osborn, J. M., Chen, D., Messaoudi, I., Orloff, S. L. & Streblow, D. N., Nov 1 2012, In : Journal of virology. 86, 21, p. 11833-11844 12 p.

Research output: Contribution to journalArticle

22 Scopus citations

Cytomegalovirus infection of the rat developing brain in utero prominently targets immune cells and promotes early microglial activation

Cloarec, R., Bauer, S., Luche, H., Buhler, E., Pallesi-Pocachard, E., Salmi, M., Courtens, S., Massacrier, A., Grenot, P., Teissier, N., Watrin, F., Schaller, F., Adle-Biassette, H., Gressens, P., Malissen, M., Stamminger, T., Streblow, D. N., Bruneau, N. & Szepetowski, P., Jul 2016, In : PloS one. 11, 7, e0160176.

Research output: Contribution to journalArticle

7 Scopus citations

Cytomegalovirus latency promotes cardiac lymphoid neogenesis and accelerated allograft rejection in CMV Naïve recipients

Orloff, S. L., Hwee, Y. K., Kreklywich, C., Andoh, T. F., Hart, E., Smith, P. A., Messaoudi, I. & Streblow, D. N., Jan 1 2011, In : American Journal of Transplantation. 11, 1, p. 45-55 11 p.

Research output: Contribution to journalArticle

19 Scopus citations

Cytomegalovirus-mediated upregulation of chemokine expression correlates with the acceleration of chronic rejection in rat heart transplants

Streblow, D. N., Kreklywich, C., Yin, Q., De La Melena, V. T., Corless, C. L., Smith, P. A., Brakebill, C., Cook, J. W., Vink, C., Bruggeman, C. A., Nelson, J. A. & Orloff, S. L., Feb 1 2003, In : Journal of virology. 77, 3, p. 2182-2194 13 p.

Research output: Contribution to journalArticle

68 Scopus citations

Cytomegalovirus microRNA expression is tissue specific and is associated with persistence

Meyer, C., Grey, F., Kreklywich, C. N., Andoh, T. F., Tirabassi, R. S., Orloff, S. L. & Streblow, D. N., Jan 1 2011, In : Journal of virology. 85, 1, p. 378-389 12 p.

Research output: Contribution to journalArticle

27 Scopus citations

Cytomegalovirus pp65 limits dissemination but is dispensable for persistence

Malouli, D., Hansen, S. G., Nakayasu, E. S., Marshall, E. E., Hughes, C. M., Ventura, A. B., Gilbride, R. M., Lewis, M. S., Xu, G., Kreklywich, C., Whizin, N., Fischer, M., Legasse, A. W., Viswanathan, K., Siess, D., Camp, D. G., Axthelm, M. K., Kahl, C., DeFilippis, V. R., Smith, R. D. & 3 others, Streblow, D. N., Picker, L. J. & Früh, K., 2014, In : Journal of Clinical Investigation. 124, 5, p. 1928-1944 17 p.

Research output: Contribution to journalArticle

19 Scopus citations

Differential ligand binding to a human cytomegalovirus chemokine receptor determines cell type-specific motility

Vomaske, J., Melnychuk, R. M., Smith, P. P., Powell, J., Hall, L., DeFilippis, V., Früh, K., Smit, M., Schlaepfer, D. D., Nelson, J. A. & Streblow, D. N., Feb 1 2009, In : PLoS pathogens. 5, 2, e1000304.

Research output: Contribution to journalArticle

38 Scopus citations

Differential regulation of cell motility and invasion by FAK

Hsia, D. A., Mitra, S. K., Hauck, C. R., Streblow, D. N., Nelson, J. A., Ilic, D., Huang, S., Li, E., Nemerow, G. R., Leng, J., Spencer, K. S. R., Cheresh, D. A. & Schlaepfer, D. D., Mar 3 2003, In : Journal of Cell Biology. 160, 5, p. 753-767 15 p.

Research output: Contribution to journalArticle

422 Scopus citations

Do pathogens accelerate atherosclerosis?

Streblow, D. N., Orloff, S. L. & Nelson, J. A., Oct 20 2001, In : Journal of Nutrition. 131, 10, p. 2798S-2804S

Research output: Contribution to journalArticle

115 Scopus citations

Dysregulated TGF-β Production Underlies the Age-Related Vulnerability to Chikungunya Virus

Uhrlaub, J. L., Pulko, V., DeFilippis, V. R., Broeckel, R., Streblow, D. N., Coleman, G. D., Park, B. S., Lindo, J. F., Vickers, I., Anzinger, J. J. & Nikolich-Žugich, J., Oct 2016, In : PLoS pathogens. 12, 10, e1005891.

Research output: Contribution to journalArticle

14 Scopus citations

Elimination of donor-specific alloreactivity prevents cytomegalovirus-accelerated chronic rejection in rat small bowel and heart transplants

Orloff, S. L., Streblow, D. N., Soderberg-Naucler, C., Yin, Q., Kreklywich, C., Corless, C. L., Smith, P. A., Loomis, C. B., Mills, L. K., Cook, J. W., Bruggeman, C. A., Nelson, J. A. & Wagner, C. R., Mar 15 2002, In : Transplantation. 73, 5, p. 679-688 10 p.

Research output: Contribution to journalArticle

38 Scopus citations

Emerging alphaviruses are sensitive to cellular states induced by a novel small-molecule agonist of the STING pathway

Gall, B., Pryke, K., Abraham, J., Mizuno, N., Botto, S., Sali, T. M., Broeckel, R., Haese, N., Nilsen, A., Placzek, A., Morrison, T., Heise, M., Streblow, D. & De Filippis, V., Mar 1 2018, In : Journal of Virology. 92, 6, e01913-17.

Research output: Contribution to journalArticle

9 Scopus citations

Enhancing safety of cytomegalovirus-based vaccine vectors by engaging host intrinsic immunity

Marshall, E., Malouli, D., Hansen, S., Gilbride, R. M., Hughes, C. M., Ventura, A. B., Ainslie, E., Selseth, A. N., Ford, J. C., Burke, D., Kreklywich, C. N., Womack, J., Legasse, A. W., Axthelm, M., Kahl, C., Streblow, D., Edlefsen, P. T., Picker, L. & Frueh, K., Jul 17 2019, In : Science Translational Medicine. 11, 501, eaaw2603.

Research output: Contribution to journalArticle

6 Scopus citations

FAK promotes organization of fibronectin matrix and fibrillar adhesions

Ilić, D., Kovačič, B., Johkura, K., Schlaepfer, D. D., Tomašević, N., Han, Q., Kim, J. B., Howerton, K., Baumbusch, C., Ogiwara, N., Streblow, D. N., Nelson, J. A., Dazin, P., Shino, Y., Sasaki, K. & Damsky, C. H., Jan 15 2004, In : Journal of Cell Science. 117, 2, p. 177-187 11 p.

Research output: Contribution to journalArticle

88 Scopus citations

Fluorescence-based laser capture microscopy technology facilitates identification of critical in vivo cytomegalovirus transcriptional programs

Kreklywich, C. N., Smith, P. P., Jones, C. B., Cornea, A., Orloff, S. L. & Streblow, D. N., Jan 1 2014, In : Methods in Molecular Biology. 1119, p. 217-237 21 p.

Research output: Contribution to journalArticle

2 Scopus citations

Focal adhesion kinase is critical for entry of Kaposi's sarcoma-associated herpesvirus into target cells

Krishnan, H. H., Sharma-Walia, N., Streblow, D. N., Naranatt, P. P. & Chandran, B., Feb 1 2006, In : Journal of virology. 80, 3, p. 1167-1180 14 p.

Research output: Contribution to journalArticle

73 Scopus citations

Gag protein from human immunodeficiency virus type 1 assembles in the absence of cyclophilin A

Streblow, D. N., Kitabwalla, M. & Pauza, C. D., Dec 5 1998, In : Virology. 252, 1, p. 228-234 7 p.

Research output: Contribution to journalArticle

7 Scopus citations

Granulocyte-colony stimulating factor reactivates human cytomegalovirus in a latently infected humanized mouse model

Smith, M. S., Goldman, D. C., Bailey, A. S., Pfaffle, D. L., Kreklywich, C. N., Spencer, D. B., Othieno, F. A., Streblow, D. N., Garcia, J. V., Fleming, W. H. & Nelson, J. A., Sep 16 2010, In : Cell Host and Microbe. 8, 3, p. 284-291 8 p.

Research output: Contribution to journalArticle

81 Scopus citations
20 Scopus citations

HCMV trimer- and pentamer-specific antibodies synergize for virus neutralization but do not correlate with congenital transmission

Vanarsdall, A., Chin, A. L., Liu, J., Jardetzky, T. S., Mudd, J., Orloff, S., Streblow, D., Mussi-Pinhata, M. M., Yamamoto, A. Y., Duarte, G., Britt, W. J. & Johnson, D., Feb 26 2019, In : Proceedings of the National Academy of Sciences of the United States of America. 116, 9, p. 3728-3733 6 p.

Research output: Contribution to journalArticle

Open Access
8 Scopus citations

HLA-E-dependent presentation of Mtb-derived antigen to human CD8+ T cells

Heinzel, A. S., Grotzke, J. E., Lines, R. A., Lewinsohn, D. A., McNabb, A. L., Streblow, D. N., Brand, V. M., Grieser, H. J., Belisle, J. T. & Lewinsohn, D. M., Dec 2 2002, In : Journal of Experimental Medicine. 196, 11, p. 1473-1481 9 p.

Research output: Contribution to journalArticle

151 Scopus citations

Human cytomegalovirus carries a cell-derived phospholipase A2 required for infectivity

Allal, C., Buisson-Brenac, C., Marion, V., Claudel-Renard, C., Faraut, T., Dal Monte, P., Streblow, D., Record, M. & Davignon, J. L., Jul 1 2004, In : Journal of virology. 78, 14, p. 7717-7726 10 p.

Research output: Contribution to journalArticle

17 Scopus citations

Human Cytomegalovirus Chemokine Receptor US28-induced Smooth Muscle Cell Migration is Mediated by Focal Adhesion Kinase and Src

Streblow, D. N., Vomaske, J., Smith, P., Melnychuk, R., Hall, L., Pancheva, D., Smit, M., Casarosa, P., Schlaepfer, D. D. & Nelson, J. A., Dec 12 2003, In : Journal of Biological Chemistry. 278, 50, p. 50456-50465 10 p.

Research output: Contribution to journalArticle

74 Scopus citations

Human cytomegalovirus-encoded G protein-coupled receptor US28 mediates smooth muscle cell migration through Gα12

Melnychuk, R. M., Streblow, D. N., Smith, P. P., Hirsch, A. J., Pancheva, D. & Nelson, J. A., Aug 1 2004, In : Journal of virology. 78, 15, p. 8382-8391 10 p.

Research output: Contribution to journalArticle

50 Scopus citations

Human Cytomegalovirus Immediate Early 86-kDa Protein Blocks Transcription and Induces Degradation of the Immature Interleukin-1β Protein during Virion-Mediated Activation of the AIM2 Inflammasome

Botto, S., Abraham, J., Mizuno, N., Pryke, K., Gall, B., Landais, I., Streblow, D., Frueh, K. & De Filippis, V., Feb 12 2019, In : mBio. 10, 1

Research output: Contribution to journalArticle

Open Access
4 Scopus citations

Human cytomegalovirus induces cellular and humoral virus-specific immune responses in humanized BLT mice

Crawford, L. B., Tempel, R., Streblow, D., Kreklywich, C., Smith, P., Picker, L., Nelson, J. & Caposio, P., Dec 1 2017, In : Scientific Reports. 7, 1, 937.

Research output: Contribution to journalArticle

17 Scopus citations

Human cytomegalovirus induces upregulation of arginase II: Possible implications for vasculopathies

Yaiw, K. C., Mohammad, A. A., Taher, C., Wilhelmi, V., Davoudi, B., Strååt, K., Assinger, A., Ovchinnikova, O., Shlyakhto, E., Rahbar, A., Koutonguk, O., Religa, P., Butler, L., Khan, Z., Streblow, D., Pernow, J. & Söderberg-Nauclér, C., Mar 2014, In : Basic Research in Cardiology. 109, 2, 401.

Research output: Contribution to journalArticle

9 Scopus citations

Human Cytomegalovirus miR-UL112-3p Targets TLR2 and Modulates the TLR2/IRAK1/NFκB Signaling Pathway

Landais, I., Pelton, C., Streblow, D., DeFilippis, V., McWeeney, S. & Nelson, J. A., May 1 2015, In : PLoS pathogens. 11, 5, e1004881.

Research output: Contribution to journalArticle

50 Scopus citations

Human cytomegalovirus secretome contains factors that induce angiogenesis and wound healing

Dumortier, J., Streblow, D. N., Moses, A. V., Jacobs, J. M., Kreklywich, C. N., Camp, D., Smith, R. D., Orloff, S. L. & Nelson, J. A., Jul 1 2008, In : Journal of virology. 82, 13, p. 6524-6535 12 p.

Research output: Contribution to journalArticle

82 Scopus citations

Human cytomegalovirus UL97 kinase activity is required for the hyperphosphorylation of retinoblastoma protein and inhibits the formation of nuclear aggresomes

Prichard, M. N., Sztul, E., Daily, S. L., Perry, A. L., Frederick, S. L., Gill, R. B., Hartline, C. B., Streblow, D. N., Varnum, S. M., Smith, R. D. & Kern, E. R., May 1 2008, In : Journal of virology. 82, 10, p. 5054-5067 14 p.

Research output: Contribution to journalArticle

80 Scopus citations

Human cytomegalovirus US28: A functionally selective chemokine binding receptor

Vomaske, J., Nelson, J. A. & Streblow, D. N., Oct 5 2009, In : Infectious Disorders - Drug Targets. 9, 5, p. 548-556 9 p.

Research output: Contribution to journalArticle

29 Scopus citations

Human Cytomegalovirus US28 ligand binding activity is required for latency in CD34+ hematopoietic progenitor cells and humanized NSG mice

Crawford, L. B., Caposio, P., Kreklywich, C., Pham, A. H., Hancock, M. H., Jones, T. A., Smith, P. P., Yurochko, A. D., Nelson, J. A. & Streblow, D. N., Jan 1 2019, In : mBio. 10, 4, e01889-19.

Research output: Contribution to journalArticle

Open Access
5 Scopus citations

Identification of proteins in human cytomegalovirus (HCMV) particles: The HCMV proteome

Varnum, S. M., Streblow, D. N., Monroe, M. E., Smith, P., Auberry, K. J., Paša-Tolić, L., Wang, D., Camp, D. G., Rodland, K., Wiley, S., Britt, W., Shenk, T., Smith, R. D. & Nelson, J. A., Oct 1 2004, In : Journal of virology. 78, 20, p. 10960-10966 7 p.

Research output: Contribution to journalArticle

409 Scopus citations

IL-6 in human cytomegalovirus secretome promotes angiogenesis and survival of endothelial cells through the stimulation of survivin

Botto, S., Streblow, D. N., DeFilippis, V., White, L., Kreklywich, C. N., Smith, P. P. & Caposio, P., Jan 6 2011, In : Blood. 117, 1, p. 352-361 10 p.

Research output: Contribution to journalArticle

67 Scopus citations

Infection of APC by human cytomegalovirus controlled through recognition of endogenous nuclear immediate early protein 1 by specific CD4+ T lymphocytes

Le Roy, E., Baron, M., Faigle, W., Clément, D., Lewinsohn, D. M., Streblow, D. N., Nelson, J. A., Amigorena, S. & Davignon, J. L., Aug 1 2002, In : Journal of Immunology. 169, 3, p. 1293-1301 9 p.

Research output: Contribution to journalArticle

Open Access
21 Scopus citations

Integrin α4β1 promotes focal adhesion kinase-independent cell motility via α4 cytoplasmic domain-specific activation of c-Src

Hsia, D. A., Lim, S. T., Bernard-Trifilo, J. A., Mitra, S. K., Tanaka, S., Den Hertog, J., Streblow, D. N., Ilic, D., Ginsberg, M. H. & Schlaepfer, D. D., Nov 1 2005, In : Molecular and cellular biology. 25, 21, p. 9700-9712 13 p.

Research output: Contribution to journalArticle

65 Scopus citations

In utero administration of drugs targeting microglia improves the neurodevelopmental outcome following cytomegalovirus infection of the rat fetal brain

Cloarec, R., Bauer, S., Teissier, N., Schaller, F., Luche, H., Courtens, S., Salmi, M., Pauly, V., Bois, E., Pallesi-Pocachard, E., Buhler, E., Michel, F. J., Gressens, P., Malissen, M., Stamminger, T., Streblow, D. N., Bruneau, N. & Szepetowski, P., Mar 6 2018, In : Frontiers in Cellular Neuroscience. 12, 55.

Research output: Contribution to journalArticle

3 Scopus citations
8 Scopus citations