Ben Emery

Associate Professor

  • 4636 Citations
  • 24 h-Index
20012019
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Research Output 2001 2019

  • 4636 Citations
  • 24 h-Index
  • 40 Article
  • 2 Review article
  • 1 Chapter
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Article
2019
2 Citations (Scopus)

Variants in myelin regulatory factor (MYRF) cause autosomal dominant and syndromic nanophthalmos in humans and retinal degeneration in mice

Genomic Ascertainment Cohort, May 1 2019, In : PLoS genetics. 15, 5, p. e1008130

Research output: Contribution to journalArticle

Open Access
Retinal Degeneration
myelin sheath
Myelin Sheath
Hyperopia
gene
2018
2 Citations (Scopus)

Amyloid precursor protein and amyloid precursor-like protein 2 have distinct roles in modulating myelination, demyelination, and remyelination of axons

Truong, P. H., Ciccotosto, G. D., Merson, T. D., Spoerri, L., Chuei, M. J., Ayers, M., Xing, Y. L., Emery, B. & Cappai, R., Jan 1 2018, (Accepted/In press) In : GLIA.

Research output: Contribution to journalArticle

Amyloid beta-Protein Precursor
Demyelinating Diseases
Axons
Cuprizone
Proteins
9 Citations (Scopus)

A TLR/AKT/FoxO3 immune tolerance-like pathway disrupts the repair capacity of oligodendrocyte progenitors

Srivastava, T., Diba, P., Dean, J. M., Banine, F., Shaver, D., Hagen, M., Gong, X., Su, W., Emery, B., Marks, D., Harris, E. N., Baggenstoss, B., Weigel, P. H., Sherman, L. L. & Back, S., May 1 2018, In : Journal of Clinical Investigation. 128, 5, p. 2025-2041 17 p.

Research output: Contribution to journalArticle

Immune Tolerance
Oligodendroglia
Stem Cells
Hyaluronic Acid
Cell Differentiation
44 Citations (Scopus)

Pharmacogenetic stimulation of neuronal activity increases myelination in an axon-specific manner

Mitew, S., Gobius, I., Fenlon, L. R., McDougall, S. J., Hawkes, D., Xing, Y. L., Bujalka, H., Gundlach, A. L., Richards, L. J., Kilpatrick, T. J., Merson, T. D. & Emery, B., Dec 1 2018, In : Nature Communications. 9, 1, 306.

Research output: Contribution to journalArticle

axons
Pharmacogenetics
stimulation
Axons
myelin
2017
22 Citations (Scopus)

Myelin regulatory factor drives remyelination in multiple sclerosis

Duncan, G. J., Plemel, J. R., Assinck, P., Manesh, S. B., Muir, F. G. W., Hirata, R., Berson, M., Liu, J., Wegner, M., Emery, B., Moore, G. R. W. & Tetzlaff, W., Jun 19 2017, (Accepted/In press) In : Acta Neuropathologica. p. 1-20 20 p.

Research output: Contribution to journalArticle

Oligodendroglia
Myelin Sheath
Multiple Sclerosis
Demyelinating Diseases
Transcription Factors
2016
1 Citation (Scopus)

Cellular mechanisms of adaptive myelination: bridging the gap between animal studies and human cognition

Bujalka, H. & Emery, B., Jul 22 2016, (Accepted/In press) In : Cognitive Neuroscience. p. 1-3 3 p.

Research output: Contribution to journalArticle

Cognition
Learning
Neuronal Plasticity
Oligodendroglia
Myelin Sheath
26 Citations (Scopus)

Functional Characterization of DNA Methylation in the Oligodendrocyte Lineage

Moyon, S., Huynh, J. L., Dutta, D., Zhang, F., Ma, D., Yoo, S., Lawrence, R., Wegner, M., John, G. R., Emery, B., Lubetzki, C., Franklin, R. J. M., Fan, G., Zhu, J., Dupree, J. L. & Casaccia, P., Apr 26 2016, In : Cell Reports. 15, 4, p. 748-760 13 p.

Research output: Contribution to journalArticle

RNA Sequence Analysis
Oligodendroglia
DNA Methylation
RNA
Ablation
101 Citations (Scopus)

Rapid production of new oligodendrocytes is required in the earliest stages of motor-skill learning

Xiao, L., Ohayon, D., McKenzie, I. A., Sinclair-Wilson, A., Wright, J. L., Fudge, A. D., Emery, B., Li, H. & Richardson, W. D., Jul 25 2016, (Accepted/In press) In : Nature Neuroscience.

Research output: Contribution to journalArticle

Motor Skills
Oligodendroglia
Learning
Running
Motor Cortex
2015
45 Citations (Scopus)

Differential Sox10 genomic occupancy in myelinating glia

Lopez-Anido, C., Sun, G., Koenning, M., Srinivasan, R., Hung, H. A., Emery, B., Keles, S. & Svaren, J., Nov 1 2015, In : GLIA. 63, 11, p. 1897-1914 18 p.

Research output: Contribution to journalArticle

Schwann Cells
Neuroglia
Oligodendroglia
Myelin Sheath
Binding Sites
73 Citations (Scopus)
Oligodendroglia
Neurology
Epigenomics
Transcription Factors
Central Nervous System
2014
13 Citations (Scopus)

Axonally derived matrilin-2 induces proinflammatory responses that exacerbate autoimmune neuroinflammation

Jonas, A., Thiem, S., Kuhlmann, T., Wagener, R., Aszodi, A., Nowell, C., Hagemeier, K., Laverick, L., Perreau, V., Jokubaitis, V., Emery, B., Kilpatrick, T., Butzkueven, H. & Gresle, M., Nov 3 2014, In : Journal of Clinical Investigation. 124, 11, p. 5042-5056 15 p.

Research output: Contribution to journalArticle

Matrilin Proteins
Autoimmunity
Autoimmune Experimental Encephalomyelitis
Multiple Sclerosis
Wounds and Injuries
115 Citations (Scopus)

Mechanisms regulating the development of oligodendrocytes and central nervous system myelin

Mitew, S., Hay, C. M., Peckham, H., Xiao, J., Koenning, M. & Emery, B., Sep 12 2014, In : Neuroscience. 276, p. 29-47 19 p.

Research output: Contribution to journalArticle

Oligodendroglia
Myelin Sheath
Central Nervous System
Neural Conduction
Axons
351 Citations (Scopus)

Motor skill learning requires active central myelination

McKenzie, I. A., Ohayon, D., Li, H., De Faria, J. P., Emery, B., Tohyama, K. & Richardson, W. D., Oct 17 2014, In : Science. 346, 6207, p. 318-322 5 p.

Research output: Contribution to journalArticle

Problem-Based Learning
Motor Skills
Oligodendroglia
Myelin Sheath
Learning
2013
90 Citations (Scopus)

MYRF Is a Membrane-Associated Transcription Factor That Autoproteolytically Cleaves to Directly Activate Myelin Genes

Bujalka, H., Koenning, M., Jackson, S., Perreau, V. M., Pope, B., Hay, C. M., Mitew, S., Hill, A. F., Lu, Q. R., Wegner, M., Srinivasan, R., Svaren, J., Willingham, M., Barres, B. A. & Emery, B., Aug 2013, In : PLoS Biology. 11, 8, e1001625.

Research output: Contribution to journalArticle

myelin sheath
Neurology
Myelin Sheath
Transcription Factors
transcription factors
9 Citations (Scopus)

Playing the Field: Sox10 Recruits Different Partners to Drive Central and Peripheral Myelination

Emery, B., Oct 2013, In : PLoS Genetics. 9, 10, e1003918.

Research output: Contribution to journalArticle

SOXE Transcription Factors
Early Growth Response Protein 2
myelination
Schwann cells
Gene Regulatory Networks
9 Citations (Scopus)

Purification and culture of oligodendrocyte lineage cells

Dugas, J. C. & Emery, B., 2013, In : Cold Spring Harbor Protocols. 2013, 9, p. 810-814 5 p.

Research output: Contribution to journalArticle

Oligodendroglia
Gene expression
Purification
Fibroblast Growth Factors
Platelet-Derived Growth Factor
34 Citations (Scopus)

Purification of oligodendrocyte lineage cells from mouse cortices by immunopanning

Emery, B. & Dugas, J. C., 2013, In : Cold Spring Harbor Protocols. 2013, 9, p. 854-868 15 p.

Research output: Contribution to journalArticle

Oligodendroglia
Neurology
Purification
Genetic Models
Myelin Sheath
21 Citations (Scopus)

Purification of oligodendrocyte precursor cells from rat cortices by immunopanning

Dugas, J. C. & Emery, B., Aug 2013, In : Cold Spring Harbor Protocols. 2013, 8, p. 745-758 14 p.

Research output: Contribution to journalArticle

Oligodendroglia
Purification
Rats
Brain
Tissue

Transcriptional regulation and specification of neural stem cells.

Christie, K. J., Emery, B., Denham, M., Bujalka, H., Cate, H. S. & Turnley, A. M., 2013, In : Advances in Experimental Medicine and Biology. 786, p. 129-155 27 p.

Research output: Contribution to journalArticle

Neural Stem Cells
Stem cells
Specifications
Adult Stem Cells
Induced Pluripotent Stem Cells
2012
15 Citations (Scopus)

Leukemia Inhibitory Factor Protects Axons in Experimental Autoimmune Encephalomyelitis via an Oligodendrocyte-Independent Mechanism

Gresle, M. M., Alexandrou, E., Wu, Q., Egan, G., Jokubaitis, V., Ayers, M., Jonas, A., Doherty, W., Friedhuber, A., Shaw, G., Sendtner, M., Emery, B., Kilpatrick, T. & Butzkueven, H., Oct 15 2012, In : PLoS One. 7, 10, e47379.

Research output: Contribution to journalArticle

Ciliary Neurotrophic Factor
Leukemia Inhibitory Factor
Autoimmune Experimental Encephalomyelitis
Oligodendroglia
encephalitis
83 Citations (Scopus)

Myelin gene regulatory factor is required for maintenance of myelin and mature oligodendrocyte identity in the adult CNS

Koenning, M., Jackson, S., Hay, C. M., Faux, C., Kilpatrick, T. J., Willingham, M. & Emery, B., Sep 5 2012, In : Journal of Neuroscience. 32, 36, p. 12528-12542 15 p.

Research output: Contribution to journalArticle

Oligodendroglia
Regulator Genes
Myelin Sheath
Maintenance
Demyelinating Diseases
2010
330 Citations (Scopus)

Dicer1 and miR-219 Are Required for Normal Oligodendrocyte Differentiation and Myelination

Dugas, J. C., Cuellar, T. L., Scholze, A., Ason, B., Ibrahim, A., Emery, B., Zamanian, J. L., Foo, L. C., McManus, M. T. & Barres, B. A., Mar 11 2010, In : Neuron. 65, 5, p. 597-611 15 p.

Research output: Contribution to journalArticle

Oligodendroglia
MicroRNAs
Transgenic Mice
Cell Proliferation
Proteins
57 Citations (Scopus)

Modulation of bone morphogenic protein signalling alters numbers of astrocytes and oligodendroglia in the subventricular zone during cuprizone-induced demyelination

Cate, H. S., Sabo, J. K., Merlo, D., Kemper, D., Aumann, T. D., Robinson, J., Merson, T. D., Emery, B., Perreau, V. M. & Kilpatrick, T. J., 2010, In : Journal of Neurochemistry. 115, 1, p. 11-22 12 p.

Research output: Contribution to journalArticle

Cuprizone
Lateral Ventricles
Oligodendroglia
Demyelinating Diseases
Astrocytes
327 Citations (Scopus)

Regulation of oligodendrocyte differentiation and myelination

Emery, B., Nov 5 2010, In : Science. 330, 6005, p. 779-782 4 p.

Research output: Contribution to journalArticle

Oligodendroglia
Myelin Sheath
Central Nervous System
Demyelinating Diseases
Regulator Genes
66 Citations (Scopus)

Transcriptional and post-transcriptional control of CNS myelination

Emery, B., Oct 2010, In : Current Opinion in Neurobiology. 20, 5, p. 601-607 7 p.

Research output: Contribution to journalArticle

Oligodendroglia
Axons
Myelin Sheath
Lateral Ventricles
Demyelinating Diseases
44 Citations (Scopus)

ZFP191 is required by oligodendrocytes for CNS myelination

Howng, S. Y. B., Avila, R. L., Emery, B., Traka, M., Lin, W., Watkins, T., Cook, S., Bronson, R., Davisson, M., Barres, B. A. & Popko, B., Feb 1 2010, In : Genes and Development. 24, 3, p. 301-311 11 p.

Research output: Contribution to journalArticle

Oligodendroglia
Zinc Fingers
Myelin Sheath
Mutant Strains Mice
Insertional Mutagenesis
2009
232 Citations (Scopus)

Myelin Gene Regulatory Factor Is a Critical Transcriptional Regulator Required for CNS Myelination

Emery, B., Agalliu, D., Cahoy, J. D., Watkins, T. A., Dugas, J. C., Mulinyawe, S. B., Ibrahim, A., Ligon, K. L., Rowitch, D. H. & Barres, B. A., Jul 10 2009, In : Cell. 138, 1, p. 172-185 14 p.

Research output: Contribution to journalArticle

Regulator Genes
Myelin Sheath
Genes
Oligodendroglia
Gene Expression
2008
1686 Citations (Scopus)

A transcriptome database for astrocytes, neurons, and oligodendrocytes: A new resource for understanding brain development and function

Cahoy, J. D., Emery, B., Kaushal, A., Foo, L. C., Zamanian, J. L., Christopherson, K. S., Xing, Y., Lubischer, J. L., Krieg, P. A., Krupenko, S. A., Thompson, W. J. & Barres, B. A., Jan 2 2008, In : Journal of Neuroscience. 28, 1, p. 264-278 15 p.

Research output: Contribution to journalArticle

Oligodendroglia
Transcriptome
Astrocytes
Databases
Neurons
213 Citations (Scopus)

Distinct Stages of Myelination Regulated by γ-Secretase and Astrocytes in a Rapidly Myelinating CNS Coculture System

Watkins, T. A., Emery, B., Mulinyawe, S. & Barres, B. A., Nov 26 2008, In : Neuron. 60, 4, p. 555-569 15 p.

Research output: Contribution to journalArticle

Amyloid Precursor Protein Secretases
Oligodendroglia
Myelin Sheath
Coculture Techniques
Astrocytes
61 Citations (Scopus)

Leukemia inhibitory factor signaling modulates both central nervous system demyelination and myelin repair

Marriott, M. P., Emery, B., Cate, H. S., Binder, M. D., Kemper, D., Wu, Q., Kolbe, S., Gordon, I. R., Wang, H., Egan, G., Murray, S., Butzkueven, H. & Kilpatrick, T. J., Apr 15 2008, In : GLIA. 56, 6, p. 686-698 13 p.

Research output: Contribution to journalArticle

Leukemia Inhibitory Factor
Demyelinating Diseases
Myelin Sheath
Central Nervous System
Cuprizone
9 Citations (Scopus)

Unlocking CNS Cell Type Heterogeneity

Emery, B. & Barres, B. A., Nov 14 2008, In : Cell. 135, 4, p. 596-598 3 p.

Research output: Contribution to journalArticle

Neurology
Central Nervous System
Brain
Cells
Messenger RNA
2006
73 Citations (Scopus)

Endogenous leukemia inhibitory factor production limits autoimmune demyelination and oligodendrocyte loss

Butzkueven, H., Emery, B., Cipriani, T., Marriott, M. P. & Kilpatrick, T. J., May 2006, In : GLIA. 53, 7, p. 696-703 8 p.

Research output: Contribution to journalArticle

Leukemia Inhibitory Factor
Oligodendroglia
Demyelinating Diseases
Encephalomyelitis
Spinal Cord
9 Citations (Scopus)
STAT1 Transcription Factor
Leukemia Inhibitory Factor
Oligodendroglia
Interferon-gamma
Cytokines
22 Citations (Scopus)

SOCS3 negatively regulates LIF signaling in neural precursor cells

Emery, B., Merson, T. D., Snell, C., Young, K. M., Ernst, M. & Kilpatrick, T. J., Apr 2006, In : Molecular and Cellular Neuroscience. 31, 4, p. 739-747 9 p.

Research output: Contribution to journalArticle

Cytokines
Ciliary Neurotrophic Factor
Embryonic Structures
Cell Culture Techniques
Phosphorylation
55 Citations (Scopus)

Suppressor of cytokine signaling 3 limits protection of leukemia inhibitory factor receptor signaling against central demyelination

Emery, B., Cate, H. S., Marriott, M., Merson, T., Binder, M. D., Snell, C., Soo, P. Y., Murray, S., Croker, B., Zhang, J. G., Alexander, W. S., Cooper, H., Butzkueven, H. & Kilpatrick, T. J., May 16 2006, In : Proceedings of the National Academy of Sciences of the United States of America. 103, 20, p. 7859-7864 6 p.

Research output: Contribution to journalArticle

OSM-LIF Receptors
Oligodendroglia
Demyelinating Diseases
Cytokines
Knockout Mice
2004
74 Citations (Scopus)

LIF receptor signaling modulates neural stem cell renewal

Pitman, M., Emery, B., Binder, M., Wang, S., Butzkueven, H. & Kilpatrick, T. J., Nov 2004, In : Molecular and Cellular Neuroscience. 27, 3, p. 255-266 12 p.

Research output: Contribution to journalArticle

OSM-LIF Receptors
Neural Stem Cells
Leukemia Inhibitory Factor
Fibroblast Growth Factor 2
Epidermal Growth Factor
2 Citations (Scopus)

Neuroglial responses to CNS injury: Prospects for novel therapeutics

Kilpatrick, T. J., Butzkueven, H., Emery, B., Marriott, M., Taylor, B. V. & Tubridy, N., Sep 2004, In : Expert Review of Neurotherapeutics. 4, 5, p. 869-878 10 p.

Research output: Contribution to journalArticle

Multiple Sclerosis
Wounds and Injuries
OSM-LIF Receptors
Oligodendroglia
Demyelinating Diseases
2003
35 Citations (Scopus)

Schwann cell apoptosis in the postnatal axotomized sciatic nerve is mediated via NGF through the low-affinity neurotrophin receptor

Petratos, S., Butzkueven, H., Shipham, K., Cooper, H., Bucci, T., Reid, K., Lopes, E., Emery, B., Cheema, S. S. & Kilpatrick, T. J., Apr 1 2003, In : Journal of Neuropathology and Experimental Neurology. 62, 4, p. 398-411 14 p.

Research output: Contribution to journalArticle

Nerve Growth Factor Receptors
Schwann Cells
Nerve Growth Factor
Sciatic Nerve
Apoptosis
2002
224 Citations (Scopus)

LIF receptor signaling limits immune-mediated demyelination by enhancing oligodendrocyte survival

Butzkueven, H., Zhang, J. G., Soilu-Hanninen, M., Hochrein, H., Chionh, F., Shipham, K. A., Emery, B., Turnley, A. M., Petratos, S., Ernst, M., Bartlett, P. F. & Kilpatrick, T. J., 2002, In : Nature Medicine. 8, 6, p. 613-619 7 p.

Research output: Contribution to journalArticle

OSM-LIF Receptors
Oligodendroglia
Neurology
Demyelinating Diseases
Multiple Sclerosis
2001
24 Citations (Scopus)

Localization of the netrin guidance receptor, DCC, in the developing peripheral and enteric nervous systems

Seaman, C., Anderson, R., Emery, B. & Cooper, H. M., May 2001, In : Mechanisms of Development. 103, 1-2, p. 173-175 3 p.

Research output: Contribution to journalArticle

Enteric Nervous System
Peripheral Nervous System
Central Nervous System
Brain Fornix
Sensory Ganglia