Aaron Nilsen

Senior Staff Scientist

  • 665 Citations
  • 15 h-Index
20042019
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Research Output 2004 2019

  • 665 Citations
  • 15 h-Index
  • 32 Article

4′-Phosphopantetheine corrects CoA, iron, and dopamine metabolic defects in mammalian models of PKAN

Jeong, S. Y., Hogarth, P., Placzek, A., Gregory, A. M., Fox, R., Zhen, D., Hamada, J., van der Zwaag, M., Lambrechts, R., Jin, H., Nilsen, A., Cobb, J., Pham, T., Gray, N., Ralle, M., Duffy, M., Schwanemann, L., Rai, P., Freed, A., Wakeman, K. & 3 others, Woltjer, R. L., Sibon, O. C. M. & Hayflick, S. J., Jan 1 2019, (Accepted/In press) In : EMBO Molecular Medicine. e10489.

Research output: Contribution to journalArticle

Open Access
Pantothenate Kinase-Associated Neurodegeneration
Coenzyme A
Dopamine
Iron
Biomarkers

ELQ-331 as a prototype for extremely durable chemoprotection against malaria

Smilkstein, M. J., Pou, S., Krollenbrock, A., Bleyle, L. A., Dodean, R. A., Frueh, L., Hinrichs, D. J., Li, Y., Martinson, T., Munar, M. Y., Winter, R. W., Bruzual, I., Whiteside, S., Nilsen, A., Koop, D., Kelly, J. X., Kappe, S. H. I., Wilder, B. K. & Riscoe, M., Aug 27 2019, In : Malaria Journal. 18, 1, 291.

Research output: Contribution to journalArticle

Open Access
Malaria
Prodrugs
Plasmodium yoelii
Pharmacokinetics
Sporozoites
4 Citations (Scopus)

Mitochondrial type II NADH dehydrogenase of Plasmodium falciparum (PfNDH2) is dispensable in the asexual blood stages

Ke, H., Ganesan, S. M., Dass, S., Morrisey, J. M., Pou, S., Nilsen, A., Riscoe, M., Mather, M. W. & Vaidya, A. B., Apr 1 2019, In : PloS one. 14, 4, e0214023.

Research output: Contribution to journalArticle

Open Access
NADH dehydrogenase
Plasmodium falciparum
Parasites
antimalarials
Blood
1 Citation (Scopus)

Second-Generation Inhibitors of the Mitochondrial Permeability Transition Pore with Improved Plasma Stability

Šileikytė, J., Devereaux, J., de Jong, J., Schiavone, M., Jones, K., Nilsen, A., Bernardi, P., Forte, M. & Cohen, M. S., Oct 17 2019, In : ChemMedChem. 14, 20, p. 1771-1782 12 p.

Research output: Contribution to journalArticle

Plasma stability
Isoxazoles
Triazoles
Click Chemistry
Oxidative stress

Targeting mitochondria in cancer therapy could provide a basis for the selective anticancer activity

Rozanov, D., Cheltsov, A., Nilsen, A., Boniface, C., Forquer, I., Korkola, J., Gray, J., Tyner, J., Tognon, C. E., Mills, G. & Spellman, P., Mar 1 2019, In : PloS one. 14, 3, e0205623.

Research output: Contribution to journalArticle

Open Access
Mitochondria
Assays
mitochondria
therapeutics
neoplasms