TY - CHAP
T1 - Interpretation of flood-illuminated adaptive optics images in subjects with Retinitis Pigmentosa
AU - Gale, Michael J.
AU - Feng, Shu
AU - Titus, Hope E.
AU - Smith, Travis
AU - Pennesi, Mark
N1 - Publisher Copyright:
© Springer International Publishing Switzerland 2016.
PY - 2016/10/1
Y1 - 2016/10/1
N2 - The purpose of this study was to correlate features on flood-illuminated adaptive optics (AO) images with color fundus, fundus autofluorescence (FAF) and spectral domain optical coherence tomography (SD-OCT) images in patients with retinitis pigmentosa (RP). We imaged 39 subjects diagnosed with RP using the rtx1TM flood-illuminated AO camera from Imagine Eyes (Orsay, France). We observed a correlation between hyper-autofluoresence changes on FAF, disruption of the interdigitation zone (IZ) on SD-OCT and loss of reflective cone profiles on AO. Four main patterns of cone-reflectivity were seen on AO: presumed healthy cone mosaics, hypo-reflective blurred cone-like structures, higher frequency disorganized hyper-reflective spots, and lower frequency hypo-reflective spots. These regions were correlated to progressive phases of cone photoreceptor degeneration observed using SD-OCT and FAF. These results help provide interpretation of en face images obtained by flood-illuminated AO in subjects with RP. However, significant ambiguity remains as to what truly constitutes a cone, especially in areas of degeneration. With further refinements in technology, flood illuminated AO imaging has the potential to provide rapid, standardized, longitudinal and lower cost imaging in patients with retinal degeneration.
AB - The purpose of this study was to correlate features on flood-illuminated adaptive optics (AO) images with color fundus, fundus autofluorescence (FAF) and spectral domain optical coherence tomography (SD-OCT) images in patients with retinitis pigmentosa (RP). We imaged 39 subjects diagnosed with RP using the rtx1TM flood-illuminated AO camera from Imagine Eyes (Orsay, France). We observed a correlation between hyper-autofluoresence changes on FAF, disruption of the interdigitation zone (IZ) on SD-OCT and loss of reflective cone profiles on AO. Four main patterns of cone-reflectivity were seen on AO: presumed healthy cone mosaics, hypo-reflective blurred cone-like structures, higher frequency disorganized hyper-reflective spots, and lower frequency hypo-reflective spots. These regions were correlated to progressive phases of cone photoreceptor degeneration observed using SD-OCT and FAF. These results help provide interpretation of en face images obtained by flood-illuminated AO in subjects with RP. However, significant ambiguity remains as to what truly constitutes a cone, especially in areas of degeneration. With further refinements in technology, flood illuminated AO imaging has the potential to provide rapid, standardized, longitudinal and lower cost imaging in patients with retinal degeneration.
KW - Cone photoreceptors
KW - Flood
KW - Illuminated adaptive optics
KW - Multimodal imaging
KW - Retinal degeneration
KW - Retinitis pigmentosa
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U2 - 10.1007/978-3-319-17121-0_39
DO - 10.1007/978-3-319-17121-0_39
M3 - Chapter
C2 - 26427424
AN - SCOPUS:84943327783
T3 - Advances in Experimental Medicine and Biology
SP - 291
EP - 297
BT - Advances in Experimental Medicine and Biology
PB - Springer New York LLC
ER -