ZOning out Tight Junctions

Kunyoo Shin, Ben Margolis

Research output: Contribution to journalArticle

18 Scopus citations


The tight junction is an intricate seal between adjoining epithelial cells that also separates the apical and basolateral membranes within these cells. A paper in this issue of Cell by Umeda et al. (2006) demonstrates that loss of the ZO scaffolding proteins prevents the formation of tight junctions but surprisingly does not perturb apico-basal polarity.

Original languageEnglish (US)
Pages (from-to)647-649
Number of pages3
Issue number4
Publication statusPublished - Aug 25 2006
Externally publishedYes


ASJC Scopus subject areas

  • Cell Biology
  • Molecular Biology

Cite this

Shin, K., & Margolis, B. (2006). ZOning out Tight Junctions. Cell, 126(4), 647-649. https://doi.org/10.1016/j.cell.2006.08.005