ZFP57 and the targeted maintenance of postfertilization genomic imprints

Nozomi Takahashi, Dionne Gray, Ruslan Strogantsev, Angela Noon, Celia Delahaye, William C. Skarnes, Peri H. Tate, Anne C. Ferguson-Smith

Research output: Chapter in Book/Report/Conference proceedingConference contribution

14 Scopus citations

Abstract

Epigenetic modifications play an important role in modulating genome function. In mammals, inappropriate epigenetic states can cause embryonic lethality and various acquired and inherited diseases; hence, it is important to understand how such states are formed and maintained in particular genomic contexts. Genomic imprinting is a process in which epigenetic states provide a sustained memory of parental origin and cause gene expression/repression from only one of the two parental chromosomes. Genomic imprinting is therefore a valuable model to decipher the principles and processes associated with the targeting and maintenance of epigenetic states in general. Krüppel-associated box zinc finger proteins (KRAB-ZFPs) are proteins that have the potential to mediate this. ZFP57, one of the best characterized proteins in this family, has been shown to target and maintain epigenetic states at imprinting control regions after fertilization. Its role in imprinting through the use of ZFP57 mutants in mouse and the wider implications of KRAB-ZFPs for the targeted maintenance of epigenetic states are discussed here.

Original languageEnglish (US)
Title of host publication21st Century Genetics Genes at Work, 2015
EditorsTerri Grodzicker, Bruce Stillman, David Stewart
PublisherCold Spring Harbor Laboratory Press
Pages177-187
Number of pages11
ISBN (Print)9781621821472
DOIs
StatePublished - 2016
Externally publishedYes
Event21st Century Genetics Genes at Work, 2015 - Huntington, United States
Duration: May 26 2015May 31 2015

Publication series

NameCold Spring Harbor Symposia on Quantitative Biology
Volume80
ISSN (Print)0091-7451
ISSN (Electronic)1943-4456

Other

Other21st Century Genetics Genes at Work, 2015
CountryUnited States
CityHuntington
Period5/26/155/31/15

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Genetics

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