Yohimbine increases cerebrospinal fluid and plasma norepinephrine but not arginine vasopressin in humans

Elaine R. Peskind, Richard C. Veith, Daniel Dorsa, Gail Gumbrecht, Murray A. Raskind

Research output: Contribution to journalArticle

29 Citations (Scopus)

Abstract

Previous studies have demonstrated (α2-inhibitory regulation of central nervous system (CNS) noradrenergic and arginine vasopressinergic systems. We tested the hypothesis that α2-inhibition of CNS noradrenergic and vasopressinergic systems is tonic in nature by measuring the response of cerebrospinal fluid (CSF) norepinephrine (NE) and arginine vasopressin (AVP) to the ((2-antagonist yohimbine in 7 young normal male human subjects. We also evaluated the tonic nature of (α2-inhibition of the sympathetic nervous system (SNS) and of AVP release into plasma by measuring the response of plasma NF. and plasma AVP to yohimbine. CSF NE was significantly higher following yohimbine as compared to placebo. In contrast CSF AVP did not differ between yohimbine and placebo conditions. Similarly, plasma NE was significantly higher following yohimbine as compared to placebo, while plasma AVP was unchanged. These results support a tonic α2-inhibitoiy regulatory mechanism for both CNS noradrenergic systems and sympathetic outflow. Such tonic α2-inhibition could not be demonstrated for regulation of AVP levels in CSF or plasma in humans.

Original languageEnglish (US)
Pages (from-to)286-291
Number of pages6
JournalNeuroendocrinology
Volume50
Issue number3
DOIs
StatePublished - 1989
Externally publishedYes

Fingerprint

Yohimbine
Arginine Vasopressin
Cerebrospinal Fluid
Norepinephrine
Central Nervous System
Placebos
Sympathetic Nervous System
Arginine

Keywords

  • Cerebrospinal fluid
  • Norepinephrine
  • Vasopressin
  • Yohimbine

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism
  • Cellular and Molecular Neuroscience
  • Endocrine and Autonomic Systems
  • Neuroscience(all)

Cite this

Yohimbine increases cerebrospinal fluid and plasma norepinephrine but not arginine vasopressin in humans. / Peskind, Elaine R.; Veith, Richard C.; Dorsa, Daniel; Gumbrecht, Gail; Raskind, Murray A.

In: Neuroendocrinology, Vol. 50, No. 3, 1989, p. 286-291.

Research output: Contribution to journalArticle

Peskind, Elaine R. ; Veith, Richard C. ; Dorsa, Daniel ; Gumbrecht, Gail ; Raskind, Murray A. / Yohimbine increases cerebrospinal fluid and plasma norepinephrine but not arginine vasopressin in humans. In: Neuroendocrinology. 1989 ; Vol. 50, No. 3. pp. 286-291.
@article{d8f4b0fc37284b6e8513b4b1c43f6ea8,
title = "Yohimbine increases cerebrospinal fluid and plasma norepinephrine but not arginine vasopressin in humans",
abstract = "Previous studies have demonstrated (α2-inhibitory regulation of central nervous system (CNS) noradrenergic and arginine vasopressinergic systems. We tested the hypothesis that α2-inhibition of CNS noradrenergic and vasopressinergic systems is tonic in nature by measuring the response of cerebrospinal fluid (CSF) norepinephrine (NE) and arginine vasopressin (AVP) to the ((2-antagonist yohimbine in 7 young normal male human subjects. We also evaluated the tonic nature of (α2-inhibition of the sympathetic nervous system (SNS) and of AVP release into plasma by measuring the response of plasma NF. and plasma AVP to yohimbine. CSF NE was significantly higher following yohimbine as compared to placebo. In contrast CSF AVP did not differ between yohimbine and placebo conditions. Similarly, plasma NE was significantly higher following yohimbine as compared to placebo, while plasma AVP was unchanged. These results support a tonic α2-inhibitoiy regulatory mechanism for both CNS noradrenergic systems and sympathetic outflow. Such tonic α2-inhibition could not be demonstrated for regulation of AVP levels in CSF or plasma in humans.",
keywords = "Cerebrospinal fluid, Norepinephrine, Vasopressin, Yohimbine",
author = "Peskind, {Elaine R.} and Veith, {Richard C.} and Daniel Dorsa and Gail Gumbrecht and Raskind, {Murray A.}",
year = "1989",
doi = "10.1159/000125235",
language = "English (US)",
volume = "50",
pages = "286--291",
journal = "Neuroendocrinology",
issn = "0028-3835",
publisher = "S. Karger AG",
number = "3",

}

TY - JOUR

T1 - Yohimbine increases cerebrospinal fluid and plasma norepinephrine but not arginine vasopressin in humans

AU - Peskind, Elaine R.

AU - Veith, Richard C.

AU - Dorsa, Daniel

AU - Gumbrecht, Gail

AU - Raskind, Murray A.

PY - 1989

Y1 - 1989

N2 - Previous studies have demonstrated (α2-inhibitory regulation of central nervous system (CNS) noradrenergic and arginine vasopressinergic systems. We tested the hypothesis that α2-inhibition of CNS noradrenergic and vasopressinergic systems is tonic in nature by measuring the response of cerebrospinal fluid (CSF) norepinephrine (NE) and arginine vasopressin (AVP) to the ((2-antagonist yohimbine in 7 young normal male human subjects. We also evaluated the tonic nature of (α2-inhibition of the sympathetic nervous system (SNS) and of AVP release into plasma by measuring the response of plasma NF. and plasma AVP to yohimbine. CSF NE was significantly higher following yohimbine as compared to placebo. In contrast CSF AVP did not differ between yohimbine and placebo conditions. Similarly, plasma NE was significantly higher following yohimbine as compared to placebo, while plasma AVP was unchanged. These results support a tonic α2-inhibitoiy regulatory mechanism for both CNS noradrenergic systems and sympathetic outflow. Such tonic α2-inhibition could not be demonstrated for regulation of AVP levels in CSF or plasma in humans.

AB - Previous studies have demonstrated (α2-inhibitory regulation of central nervous system (CNS) noradrenergic and arginine vasopressinergic systems. We tested the hypothesis that α2-inhibition of CNS noradrenergic and vasopressinergic systems is tonic in nature by measuring the response of cerebrospinal fluid (CSF) norepinephrine (NE) and arginine vasopressin (AVP) to the ((2-antagonist yohimbine in 7 young normal male human subjects. We also evaluated the tonic nature of (α2-inhibition of the sympathetic nervous system (SNS) and of AVP release into plasma by measuring the response of plasma NF. and plasma AVP to yohimbine. CSF NE was significantly higher following yohimbine as compared to placebo. In contrast CSF AVP did not differ between yohimbine and placebo conditions. Similarly, plasma NE was significantly higher following yohimbine as compared to placebo, while plasma AVP was unchanged. These results support a tonic α2-inhibitoiy regulatory mechanism for both CNS noradrenergic systems and sympathetic outflow. Such tonic α2-inhibition could not be demonstrated for regulation of AVP levels in CSF or plasma in humans.

KW - Cerebrospinal fluid

KW - Norepinephrine

KW - Vasopressin

KW - Yohimbine

UR - http://www.scopus.com/inward/record.url?scp=0024463932&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0024463932&partnerID=8YFLogxK

U2 - 10.1159/000125235

DO - 10.1159/000125235

M3 - Article

C2 - 2552342

AN - SCOPUS:0024463932

VL - 50

SP - 286

EP - 291

JO - Neuroendocrinology

JF - Neuroendocrinology

SN - 0028-3835

IS - 3

ER -