Yawning and locomotor behavior induced by dopamine receptor agonists in mice and rats

Su Min Li, Gregory T. Collins, Noel M. Paul, Peter Grundt, Amy H. Newman, Ming Xu, David Grandy, James H. Woods, Jonathan L. Katz

    Research output: Contribution to journalArticle

    25 Citations (Scopus)

    Abstract

    Dopaminergic (DA) agonist-induced yawning in rats seems to be mediated by DA D3 receptors, and low doses of several DA agonists decrease locomotor activity, an effect attributed to presynaptic D2 receptors. Effects of several DA agonists on yawning and locomotor activity were examined in rats and mice. Yawning was reliably produced in rats, and by the cholinergic agonist, physostigmine, in both the species. However, DA agonists were ineffective in producing yawning in Swiss-Webster or DA D2R and DA D3R knockout or wild-type mice. The drugs significantly decreased locomotor activity in rats at one or two low doses, with activity returning to control levels at higher doses. In mice, the drugs decreased locomotion across a 1000-1000-10000-fold range of doses, with activity at control levels (U-91356A) or above control levels [(±)-7-hydroxy-2-dipropylaminotetralin HBr, quinpirole] at the highest doses. Low doses of agonists decreased locomotion in all mice except the DA D2R knockout mice, but were not antagonized by DA D2R or D3R antagonists (L-741 626, BP 897, or PG01037). Yawning does not provide a selective in-vivo indicator of DA D3R agonist activity in mice. Decreases in mouse locomotor activity by the DA agonists seem to be mediated by D2 DA receptors.

    Original languageEnglish (US)
    Pages (from-to)171-181
    Number of pages11
    JournalBehavioural Pharmacology
    Volume21
    Issue number3
    DOIs
    StatePublished - May 2010

    Fingerprint

    Yawning
    Dopamine Agonists
    Locomotion
    Quinpirole
    Presynaptic Receptors
    Cholinergic Agonists
    Physostigmine
    Knockout Mice
    Pharmaceutical Preparations

    Keywords

    • 7-OH-DPAT
    • BP 897
    • Dopamine agonist
    • Dopamine D2/D3 receptor
    • Knockout mouse
    • L-741626
    • PD 128907
    • PG01037
    • Quinpirole
    • U-91356A

    ASJC Scopus subject areas

    • Pharmacology
    • Psychiatry and Mental health

    Cite this

    Li, S. M., Collins, G. T., Paul, N. M., Grundt, P., Newman, A. H., Xu, M., ... Katz, J. L. (2010). Yawning and locomotor behavior induced by dopamine receptor agonists in mice and rats. Behavioural Pharmacology, 21(3), 171-181. https://doi.org/10.1097/FBP.0b013e32833a5c68

    Yawning and locomotor behavior induced by dopamine receptor agonists in mice and rats. / Li, Su Min; Collins, Gregory T.; Paul, Noel M.; Grundt, Peter; Newman, Amy H.; Xu, Ming; Grandy, David; Woods, James H.; Katz, Jonathan L.

    In: Behavioural Pharmacology, Vol. 21, No. 3, 05.2010, p. 171-181.

    Research output: Contribution to journalArticle

    Li, SM, Collins, GT, Paul, NM, Grundt, P, Newman, AH, Xu, M, Grandy, D, Woods, JH & Katz, JL 2010, 'Yawning and locomotor behavior induced by dopamine receptor agonists in mice and rats', Behavioural Pharmacology, vol. 21, no. 3, pp. 171-181. https://doi.org/10.1097/FBP.0b013e32833a5c68
    Li, Su Min ; Collins, Gregory T. ; Paul, Noel M. ; Grundt, Peter ; Newman, Amy H. ; Xu, Ming ; Grandy, David ; Woods, James H. ; Katz, Jonathan L. / Yawning and locomotor behavior induced by dopamine receptor agonists in mice and rats. In: Behavioural Pharmacology. 2010 ; Vol. 21, No. 3. pp. 171-181.
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