X-ray holography for sequencing DNA

T. Yorkey, J. Brase, J. Trebes, S. Lane, Joe Gray

Research output: Chapter in Book/Report/Conference proceedingConference contribution

3 Citations (Scopus)

Abstract

In this paper we discuss the potential for application of x-ray holographic imaging techniques to the sequencing of DNA. We formulate an approximate model for the scattering of partially coherent x-rays from an oriented DNA fiber and show the feasibility of reconstruction of heavy atom label positions from the x-ray scattering data. A series of simulations has been done to demonstrate the required reconstruction algorithms. An x-ray experiment is currently in progress to demonstrate the real feasibility of the technique.

Original languageEnglish (US)
Title of host publicationProceedings of SPIE - The International Society for Optical Engineering
EditorsJames P. Knauer, Gopal K. Shenoy
PublisherPubl by Int Soc for Optical Engineering
Pages255-259
Number of pages5
Volume1345
StatePublished - 1990
Externally publishedYes
EventAdvanced X-Ray/EUV Radiation Sources and Applications - San Diego, CA, USA
Duration: Jul 11 1990Jul 13 1990

Other

OtherAdvanced X-Ray/EUV Radiation Sources and Applications
CitySan Diego, CA, USA
Period7/11/907/13/90

Fingerprint

sequencing
Holography
holography
DNA
deoxyribonucleic acid
X rays
x rays
Scattering
x ray scattering
imaging techniques
Labels
fibers
scattering
Imaging techniques
Atoms
atoms
Fibers
simulation
Experiments

ASJC Scopus subject areas

  • Electrical and Electronic Engineering
  • Condensed Matter Physics

Cite this

Yorkey, T., Brase, J., Trebes, J., Lane, S., & Gray, J. (1990). X-ray holography for sequencing DNA. In J. P. Knauer, & G. K. Shenoy (Eds.), Proceedings of SPIE - The International Society for Optical Engineering (Vol. 1345, pp. 255-259). Publ by Int Soc for Optical Engineering.

X-ray holography for sequencing DNA. / Yorkey, T.; Brase, J.; Trebes, J.; Lane, S.; Gray, Joe.

Proceedings of SPIE - The International Society for Optical Engineering. ed. / James P. Knauer; Gopal K. Shenoy. Vol. 1345 Publ by Int Soc for Optical Engineering, 1990. p. 255-259.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Yorkey, T, Brase, J, Trebes, J, Lane, S & Gray, J 1990, X-ray holography for sequencing DNA. in JP Knauer & GK Shenoy (eds), Proceedings of SPIE - The International Society for Optical Engineering. vol. 1345, Publ by Int Soc for Optical Engineering, pp. 255-259, Advanced X-Ray/EUV Radiation Sources and Applications, San Diego, CA, USA, 7/11/90.
Yorkey T, Brase J, Trebes J, Lane S, Gray J. X-ray holography for sequencing DNA. In Knauer JP, Shenoy GK, editors, Proceedings of SPIE - The International Society for Optical Engineering. Vol. 1345. Publ by Int Soc for Optical Engineering. 1990. p. 255-259
Yorkey, T. ; Brase, J. ; Trebes, J. ; Lane, S. ; Gray, Joe. / X-ray holography for sequencing DNA. Proceedings of SPIE - The International Society for Optical Engineering. editor / James P. Knauer ; Gopal K. Shenoy. Vol. 1345 Publ by Int Soc for Optical Engineering, 1990. pp. 255-259
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