X-ray holography for sequencing DNA

T. Yorkey, J. Brase, J. Trebes, S. Lane, J. Gray

Research output: Contribution to journalConference articlepeer-review

3 Scopus citations


In this paper we discuss the potential for application of x-ray holographic imaging techniques to the sequencing of DNA. We formulate an approximate model for the scattering of partially coherent x-rays from an oriented DNA fiber and show the feasibility of reconstruction of heavy atom label positions from the x-ray scattering data. A series of simulations has been done to demonstrate the required reconstruction algorithms. An x-ray experiment is currently in progress to demonstrate the real feasibility of the technique.

Original languageEnglish (US)
Pages (from-to)255-259
Number of pages5
JournalProceedings of SPIE - The International Society for Optical Engineering
StatePublished - Dec 1 1990
Externally publishedYes
EventAdvanced X-Ray/EUV Radiation Sources and Applications - San Diego, CA, USA
Duration: Jul 11 1990Jul 13 1990

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Condensed Matter Physics
  • Computer Science Applications
  • Applied Mathematics
  • Electrical and Electronic Engineering


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