Wound healing and stress

C. G. Engeland, Phillip Marucha

Research output: Chapter in Book/Report/Conference proceedingChapter

5 Citations (Scopus)

Abstract

In both animals and humans it is well accepted that chronic stress delays dermal wound healing. This occurs through activation of both the HPA and SNS pathways. It is mediated by the release of cortisol and norepinephrine into the periphery. Through these pathways stress dysregulates the early wound repair process, prolonging the inflammatory phase of healing. A prolonged inflammatory phase results in higher bacterial counts and an increased incidence of infection, which in itself delays wound closure and worsens healing outcomes (e.g., scarring). Negative effects on wound healing caused by other factors (e.g., aging, diabetes) are exacerbated by stress.

Original languageEnglish (US)
Title of host publicationNeuroimmunology of the Skin: Basic Science to Clinical Practice
PublisherSpringer Berlin Heidelberg
Pages233-247
Number of pages15
ISBN (Print)9783540359869
DOIs
StatePublished - 2009
Externally publishedYes

Fingerprint

Wound Healing
Bacterial Load
Wounds and Injuries
Cicatrix
Hydrocortisone
Norepinephrine
Skin
Incidence
Infection

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Engeland, C. G., & Marucha, P. (2009). Wound healing and stress. In Neuroimmunology of the Skin: Basic Science to Clinical Practice (pp. 233-247). Springer Berlin Heidelberg. https://doi.org/10.1007/978-3-540-35989-0_21

Wound healing and stress. / Engeland, C. G.; Marucha, Phillip.

Neuroimmunology of the Skin: Basic Science to Clinical Practice. Springer Berlin Heidelberg, 2009. p. 233-247.

Research output: Chapter in Book/Report/Conference proceedingChapter

Engeland, CG & Marucha, P 2009, Wound healing and stress. in Neuroimmunology of the Skin: Basic Science to Clinical Practice. Springer Berlin Heidelberg, pp. 233-247. https://doi.org/10.1007/978-3-540-35989-0_21
Engeland CG, Marucha P. Wound healing and stress. In Neuroimmunology of the Skin: Basic Science to Clinical Practice. Springer Berlin Heidelberg. 2009. p. 233-247 https://doi.org/10.1007/978-3-540-35989-0_21
Engeland, C. G. ; Marucha, Phillip. / Wound healing and stress. Neuroimmunology of the Skin: Basic Science to Clinical Practice. Springer Berlin Heidelberg, 2009. pp. 233-247
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