Wound Complications in Head and Neck Squamous Cell Carcinomas After Anti–PD-1 Therapy

Victoria Hwang, Eduardo Mendez, Laura Q.M. Chow, Neal David Futran, Peter Andersen, Ryan Li, Vasu Divi, Cristina P. Rodriguez

Research output: Contribution to journalArticle


Immune checkpoint inhibitors have demonstrated activity in recurrent/metastatic head and neck squamous cell cancer, but less is known regarding their long-term sequelae. We describe four patients who, after complete responses to anti–PD-1 therapy, developed complications requiring surgical intervention. Patient 1 is a 57-year-old female whose marked tumor regression exposed some mandibular hardware. Patient 2 is a 39-year-old male who developed an ulcerated buccal lesion with exposed mandible. Patient 3 is a 66-year-old male with craniofacial osteoradionecrosis. Patient 4 is a 71-year-old male who developed an exposed and fractured mandible. All patients successfully underwent surgical intervention and remain disease free. Laryngoscope, 2019.

Original languageEnglish (US)
StatePublished - Jan 1 2019



  • checkpoint inhibitors
  • Head and neck cancer
  • head and neck squamous cell carcinoma
  • immunotherapy
  • monoclonal antibodies
  • osteoradionecrosis

ASJC Scopus subject areas

  • Otorhinolaryngology

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