Wound Complications in Head and Neck Squamous Cell Carcinomas After Anti–PD-1 Therapy

Victoria Hwang, Eduardo Mendez, Laura Q.M. Chow, Neal David Futran, Peter Andersen, Ryan Li, Vasu Divi, Cristina P. Rodriguez

Research output: Contribution to journalArticle

Abstract

Immune checkpoint inhibitors have demonstrated activity in recurrent/metastatic head and neck squamous cell cancer, but less is known regarding their long-term sequelae. We describe four patients who, after complete responses to anti–PD-1 therapy, developed complications requiring surgical intervention. Patient 1 is a 57-year-old female whose marked tumor regression exposed some mandibular hardware. Patient 2 is a 39-year-old male who developed an ulcerated buccal lesion with exposed mandible. Patient 3 is a 66-year-old male with craniofacial osteoradionecrosis. Patient 4 is a 71-year-old male who developed an exposed and fractured mandible. All patients successfully underwent surgical intervention and remain disease free. Laryngoscope, 2019.

Original languageEnglish (US)
JournalLaryngoscope
DOIs
StatePublished - Jan 1 2019

Fingerprint

Wounds and Injuries
Mandible
Therapeutics
Osteoradionecrosis
Laryngoscopes
Squamous Cell Neoplasms
Cheek
Head and Neck Neoplasms
Carcinoma, squamous cell of head and neck
Head
Neoplasms

Keywords

  • checkpoint inhibitors
  • Head and neck cancer
  • head and neck squamous cell carcinoma
  • immunotherapy
  • monoclonal antibodies
  • osteoradionecrosis

ASJC Scopus subject areas

  • Otorhinolaryngology

Cite this

Wound Complications in Head and Neck Squamous Cell Carcinomas After Anti–PD-1 Therapy. / Hwang, Victoria; Mendez, Eduardo; Chow, Laura Q.M.; Futran, Neal David; Andersen, Peter; Li, Ryan; Divi, Vasu; Rodriguez, Cristina P.

In: Laryngoscope, 01.01.2019.

Research output: Contribution to journalArticle

Hwang, Victoria ; Mendez, Eduardo ; Chow, Laura Q.M. ; Futran, Neal David ; Andersen, Peter ; Li, Ryan ; Divi, Vasu ; Rodriguez, Cristina P. / Wound Complications in Head and Neck Squamous Cell Carcinomas After Anti–PD-1 Therapy. In: Laryngoscope. 2019.
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