Wnts: up-and-coming at the synapse

Sean Speese, Vivian Budnik

Research output: Contribution to journalArticle

95 Citations (Scopus)

Abstract

Synaptic development, function and plasticity are highly regulated processes requiring a precise coordination of pre- and postsynaptic events. Recent studies have begun to highlight Wingless-Int (Wnt) signaling as a key player in synapse differentiation and function. Emerging roles of Wnts include the differentiation of synaptic specializations, microtubule dynamics, architecture of synaptic protein organization, modulation of synaptic efficacy and regulation of gene expression. These processes are driven by a variety of Wnt transduction pathways. Combined with a myriad of Wnts and Frizzled receptor family members, these pathways highlight the versatility of Wnt signaling and the potential for combinatorial use of these pathways in different aspects of synapse development and function. The identification of neurons secreting Wnt and those containing molecular components downstream of Frizzled receptors indicates that Wnts can function both as anterograde and retrograde signals. These studies open new avenues for understanding how embryonic morphogens are utilized during the development and function of synaptic networks.

Original languageEnglish (US)
Pages (from-to)268-275
Number of pages8
JournalTrends in Neurosciences
Volume30
Issue number6
DOIs
StatePublished - Jun 2007
Externally publishedYes

Fingerprint

Frizzled Receptors
Synapses
Wnt Signaling Pathway
Gene Expression Regulation
Microtubules
Organizations
Neurons
Proteins

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Wnts : up-and-coming at the synapse. / Speese, Sean; Budnik, Vivian.

In: Trends in Neurosciences, Vol. 30, No. 6, 06.2007, p. 268-275.

Research output: Contribution to journalArticle

Speese, Sean ; Budnik, Vivian. / Wnts : up-and-coming at the synapse. In: Trends in Neurosciences. 2007 ; Vol. 30, No. 6. pp. 268-275.
@article{2c2504a5719b4f0d8ccc4ce678a0239b,
title = "Wnts: up-and-coming at the synapse",
abstract = "Synaptic development, function and plasticity are highly regulated processes requiring a precise coordination of pre- and postsynaptic events. Recent studies have begun to highlight Wingless-Int (Wnt) signaling as a key player in synapse differentiation and function. Emerging roles of Wnts include the differentiation of synaptic specializations, microtubule dynamics, architecture of synaptic protein organization, modulation of synaptic efficacy and regulation of gene expression. These processes are driven by a variety of Wnt transduction pathways. Combined with a myriad of Wnts and Frizzled receptor family members, these pathways highlight the versatility of Wnt signaling and the potential for combinatorial use of these pathways in different aspects of synapse development and function. The identification of neurons secreting Wnt and those containing molecular components downstream of Frizzled receptors indicates that Wnts can function both as anterograde and retrograde signals. These studies open new avenues for understanding how embryonic morphogens are utilized during the development and function of synaptic networks.",
author = "Sean Speese and Vivian Budnik",
year = "2007",
month = "6",
doi = "10.1016/j.tins.2007.04.003",
language = "English (US)",
volume = "30",
pages = "268--275",
journal = "Trends in Neurosciences",
issn = "0378-5912",
publisher = "Elsevier Limited",
number = "6",

}

TY - JOUR

T1 - Wnts

T2 - up-and-coming at the synapse

AU - Speese, Sean

AU - Budnik, Vivian

PY - 2007/6

Y1 - 2007/6

N2 - Synaptic development, function and plasticity are highly regulated processes requiring a precise coordination of pre- and postsynaptic events. Recent studies have begun to highlight Wingless-Int (Wnt) signaling as a key player in synapse differentiation and function. Emerging roles of Wnts include the differentiation of synaptic specializations, microtubule dynamics, architecture of synaptic protein organization, modulation of synaptic efficacy and regulation of gene expression. These processes are driven by a variety of Wnt transduction pathways. Combined with a myriad of Wnts and Frizzled receptor family members, these pathways highlight the versatility of Wnt signaling and the potential for combinatorial use of these pathways in different aspects of synapse development and function. The identification of neurons secreting Wnt and those containing molecular components downstream of Frizzled receptors indicates that Wnts can function both as anterograde and retrograde signals. These studies open new avenues for understanding how embryonic morphogens are utilized during the development and function of synaptic networks.

AB - Synaptic development, function and plasticity are highly regulated processes requiring a precise coordination of pre- and postsynaptic events. Recent studies have begun to highlight Wingless-Int (Wnt) signaling as a key player in synapse differentiation and function. Emerging roles of Wnts include the differentiation of synaptic specializations, microtubule dynamics, architecture of synaptic protein organization, modulation of synaptic efficacy and regulation of gene expression. These processes are driven by a variety of Wnt transduction pathways. Combined with a myriad of Wnts and Frizzled receptor family members, these pathways highlight the versatility of Wnt signaling and the potential for combinatorial use of these pathways in different aspects of synapse development and function. The identification of neurons secreting Wnt and those containing molecular components downstream of Frizzled receptors indicates that Wnts can function both as anterograde and retrograde signals. These studies open new avenues for understanding how embryonic morphogens are utilized during the development and function of synaptic networks.

UR - http://www.scopus.com/inward/record.url?scp=34249284178&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=34249284178&partnerID=8YFLogxK

U2 - 10.1016/j.tins.2007.04.003

DO - 10.1016/j.tins.2007.04.003

M3 - Article

C2 - 17467065

AN - SCOPUS:34249284178

VL - 30

SP - 268

EP - 275

JO - Trends in Neurosciences

JF - Trends in Neurosciences

SN - 0378-5912

IS - 6

ER -