Wnt and related signaling pathways in melanomagenesis

Jesse J. Keller, Randall T. Moon, Andy J. Chien

Research output: Contribution to journalReview articlepeer-review

3 Scopus citations

Abstract

Given the pivotal roles of morphogen pathways including Wnt, Notch, Hedgehog, and BMP pathways in the development of the neural crest lineage, it is not surprising that these signaling networks have also been implicated in the biology of malignant melanoma. Understanding the mechanisms by which these pathways can alter cell fate and other biological properties in tumor cells will be essential for determining whether the therapeutic targeting of these pathways has a potential role in melanoma treatment. This review highlights some of the recent findings with regards to how morphogen signaling may regulate melanoma cell biology.

Original languageEnglish (US)
Pages (from-to)1000-1012
Number of pages13
JournalCancers
Volume2
Issue number2
DOIs
StatePublished - Jun 2010
Externally publishedYes

Keywords

  • Melanoma
  • Morphogens
  • Signal transduction
  • Wnts

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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