Wired on steroids

Sexual differentiation of the brain and its role in the expression of sexual partner preferences

Brenda M. Alexander, Donal C. Skinner, Charles Roselli

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

The preference to seek out a sexual partner of the opposite sex is robust and ensures repro- duction and survival of the species. Development of female-directed partner preference in the male is dependent on exposure of the developing brain to gonadal steroids synthe-sized during critical periods of sexual differentiation of the central nervous system. In the absence of androgen exposure, a male-directed partner preference develops. The devel-opment and expression of sexual partner preference has been extensively studied in rat, ferret, and sheep model systems. From these models it is clear that gonadal testosterone, often through estrogenic metabolites, cause both masculinization and defeminization of behavior during critical periods of brain development. Changes in the steroid environment during these critical periods result in atypical sexual partner preference. In this manuscript, we review the major findings which support the hypothesis that the organizational actions of sex steroids are responsible for sexual differentiation of sexual partner preferences in select non-human species. We also explore how this information has helped to frame our understanding of the biological influences on human sexual orientation and gender identity.

Original languageEnglish (US)
Article numberArticle 42
JournalFrontiers in Endocrinology
Volume2
Issue numberOCT
DOIs
StatePublished - 2011

Fingerprint

Sex Differentiation
Sexual Partners
Steroids
Brain
Safe Sex
Ferrets
Sexual Behavior
Androgens
Reproduction
Testosterone
Sheep
Central Nervous System
Survival
Critical Period (Psychology)

Keywords

  • Gonadal steroids
  • Preoptic area
  • Sexual differentiation
  • Sexual orientation
  • Sexual partner preference
  • Sexually dimorphic nucleus

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism

Cite this

Wired on steroids : Sexual differentiation of the brain and its role in the expression of sexual partner preferences. / Alexander, Brenda M.; Skinner, Donal C.; Roselli, Charles.

In: Frontiers in Endocrinology, Vol. 2, No. OCT, Article 42, 2011.

Research output: Contribution to journalArticle

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