Will imatinib compromise reproductive capacity?

Alberuni M. Zamah, Michael J. Mauro, Brian J. Druker, Kutluk Oktay, Merrill J. Egorin, Marcelle I. Cedars, Mitchell P. Rosen

Research output: Contribution to journalArticle

27 Scopus citations

Abstract

Imatinib mesylate is the first in a family of highly effective, minimally toxic, targeted agents used widely to treat Philadelphia-positive leukemias and selected other cancers, leading to a steady rise in the prevalence of patients using such therapy. Because failure of therapy would require conventional gonadotoxic chemotherapeutics, many female patients using imatinib may choose to preserve fertility. Herein, we provide evidence of a potential negative effect of imatinib on ovarian function by reporting the first case of a woman who showed a severely compromised ovarian response to gonadotropin stimulation while on imatinib, with a normal ovarian response after stopping this medication.

Original languageEnglish (US)
Pages (from-to)1422-1427
Number of pages6
JournalOncologist
Volume16
Issue number10
DOIs
StatePublished - Oct 26 2011

Keywords

  • Fertility
  • Growth factor
  • Leukemia
  • Ovary

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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    Zamah, A. M., Mauro, M. J., Druker, B. J., Oktay, K., Egorin, M. J., Cedars, M. I., & Rosen, M. P. (2011). Will imatinib compromise reproductive capacity? Oncologist, 16(10), 1422-1427. https://doi.org/10.1634/theoncologist.2011-0137