Why HLA-B27: An analysis based on two animal models

J. T. Rosenbaum

Research output: Contribution to journalArticlepeer-review

17 Scopus citations


The histocompatibility antigen HLA-B27 predisposes to at least 3 diseases: ankylosing spondylitis, Reiter's syndrome, and acute anterior uveitis. Despite its marked association with these diseases, the mechanism of the predisposition remains speculative. Two animal models, those of adjuvant arthritis and endotoxin-induced uveitis, are particularly relevant to an understanding of B27-related disease. An analysis of these 2 models is useful in considering hypotheses on the mechanism of the B27-related predisposition. The proposal that HLA-B27 itself or a gene closely linked to it confers an enhanced sensitivity to an inflammatory mediator such as a prostaglandin fits both with the animal models and observations on human disease. Studies to test this hypothesis are in progress.

Original languageEnglish (US)
Pages (from-to)261-263
Number of pages3
JournalAnnals of internal medicine
Issue number2
StatePublished - 1981
Externally publishedYes

ASJC Scopus subject areas

  • Internal Medicine


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