Why do omega-3 fatty acids lower serum triglycerides?

William Harris, Deepti Bulchandani

Research output: Contribution to journalArticle

246 Citations (Scopus)

Abstract

PURPOSE OF REVIEW: Fish oils rich in n-3 fatty acids reduce serum triglyceride levels. This well known effect has been shown to be caused by decreased very low-density lipoprotein triglyceride secretion rates in kinetic studies in humans. Animal studies have explored the biochemical mechanisms underlying this effect. Triglyceride synthesis could be reduced by n-3 fatty acids in three general ways: reduced substrate (i.e. fatty acids) availability, which could be secondary to increase in β-oxidation, decreased free fatty acids delivery to the liver, decreased hepatic fatty acids synthesis; increased phospholipid synthesis; or decreased activity of triglyceride-synthesizing enzymes (diacylgylcerol acyltranferase or phosphatidic acid phosphohydrolase). RECENT FINDINGS: Rarely were experimental conditions used in rat studies physiologically relevant to the human situation in which 1.2% energy as n-3 fatty acids lowers serum triglyceride levels. Nevertheless, the most consistent effect of n-3 fatty acids feeding in rats is to decrease lipogenesis. Increased β-oxidation was frequently, but not consistently, reported with similar numbers of studies reporting increased mitochondrial compared with peroxisomal oxidation. Inhibition of triglyceride-synthesizing enzymes was only occasionally noted. SUMMARY: As the vast majority of studies fed unphysiologically high doses of n-3 fatty acids, these findings in rats must be considered tentative, and the mechanism by which n-3 fatty acids reduce triglyceride levels in humans remains speculative.

Original languageEnglish (US)
Pages (from-to)387-393
Number of pages7
JournalCurrent Opinion in Lipidology
Volume17
Issue number4
DOIs
StatePublished - Aug 2006
Externally publishedYes

Fingerprint

Omega-3 Fatty Acids
Triglycerides
Serum
Rats
Oxidation
Fatty Acids
Phosphatidate Phosphatase
Lipogenesis
Fish Oils
Liver
Enzymes
Nonesterified Fatty Acids
Phospholipids
Animals
Thermodynamic properties
Availability
Kinetics
Substrates

Keywords

  • Beta-oxidation
  • Fish oils
  • Lipogenesis
  • Rats
  • Triglycerides

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Why do omega-3 fatty acids lower serum triglycerides? / Harris, William; Bulchandani, Deepti.

In: Current Opinion in Lipidology, Vol. 17, No. 4, 08.2006, p. 387-393.

Research output: Contribution to journalArticle

Harris, William ; Bulchandani, Deepti. / Why do omega-3 fatty acids lower serum triglycerides?. In: Current Opinion in Lipidology. 2006 ; Vol. 17, No. 4. pp. 387-393.
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