Whole-food sources of vitamin A more effectively inhibit female rat sexual maturation, mammary gland development, and mammary carcinogenesis than retinyl palmitate

Shauntae M. McDaniel, Caitlin O'Neill, Richard P. Metz, Elizabeth Tarbutton, Maria Stacewicz-Sapuntzakis, Jerianne Heimendinger, Pamela Wolfe, Henry Thompson, Pepper Schedin

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Previous work using an adolescent rat model for breast cancer showed increased tumor occurrence in rats fed a chemopreventive dose of vitamin A. Preclinical models for nutrient-cancer interactions utilizing defined diets do not replicate the complexity of the human diet and may be inadequate to investigate food patterns associated with reduced cancer risk in humans. To evaluate this concept, the effects of vitamin A on sexual maturation, mammary gland development, and sensitivity to carcinogenesis were determined in the context of a human food-based diet (whole food diet). At 20 d of age (p20), female rats received either a whole-food diet with adequate levels of vitamin A, a diet with a 5.5-fold increase in vitamin A from fruits and vegetables (S diet), or a diet with a 6.2-fold increase in vitamin A provided as retinyl palmitate (RP diet). To determine the effect of dietary intervention on pubertal mammary gland development, the dietary intervention period was restricted to postnatal d 21-63. Rats were injected with 50 mg 1-methyl-1-nitrosourea/kg body weight at d 66. Compared with adolescent rats that consumed the Ad diet, consumption of S and RP diets reduced mammary cancer multiplicity (relative risk 0.7, P ≤ 0.002), which was associated with a reduction in alveolar gland development. The S diet suppressed the onset of sexual maturation (P <0.001) and inhibited markers of mammary alveologenesis more than the RP diet. These data demonstrate that the amount and source of vitamin A consumed by adolescent female rats can influence the onset of puberty, mammary gland alveolar development, and breast cancer risk and highlight the relevance of utilizing whole-food diets to evaluate the role of dietary factors in cancer prevention.

Original languageEnglish (US)
Pages (from-to)1415-1422
Number of pages8
JournalJournal of Nutrition
Volume137
Issue number6
StatePublished - Jun 2007
Externally publishedYes

Fingerprint

retinyl palmitate
Sexual Maturation
Human Mammary Glands
Vitamin A
mammary glands
carcinogenesis
breasts
vitamin A
Carcinogenesis
Breast
Diet
Food
rats
diet
neoplasms
Breast Neoplasms
retinol palmitate
breast neoplasms
Neoplasms
Puberty

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Food Science

Cite this

Whole-food sources of vitamin A more effectively inhibit female rat sexual maturation, mammary gland development, and mammary carcinogenesis than retinyl palmitate. / McDaniel, Shauntae M.; O'Neill, Caitlin; Metz, Richard P.; Tarbutton, Elizabeth; Stacewicz-Sapuntzakis, Maria; Heimendinger, Jerianne; Wolfe, Pamela; Thompson, Henry; Schedin, Pepper.

In: Journal of Nutrition, Vol. 137, No. 6, 06.2007, p. 1415-1422.

Research output: Contribution to journalArticle

McDaniel, SM, O'Neill, C, Metz, RP, Tarbutton, E, Stacewicz-Sapuntzakis, M, Heimendinger, J, Wolfe, P, Thompson, H & Schedin, P 2007, 'Whole-food sources of vitamin A more effectively inhibit female rat sexual maturation, mammary gland development, and mammary carcinogenesis than retinyl palmitate', Journal of Nutrition, vol. 137, no. 6, pp. 1415-1422.
McDaniel SM, O'Neill C, Metz RP, Tarbutton E, Stacewicz-Sapuntzakis M, Heimendinger J et al. Whole-food sources of vitamin A more effectively inhibit female rat sexual maturation, mammary gland development, and mammary carcinogenesis than retinyl palmitate. Journal of Nutrition. 2007 Jun;137(6):1415-1422.
McDaniel, Shauntae M. ; O'Neill, Caitlin ; Metz, Richard P. ; Tarbutton, Elizabeth ; Stacewicz-Sapuntzakis, Maria ; Heimendinger, Jerianne ; Wolfe, Pamela ; Thompson, Henry ; Schedin, Pepper. / Whole-food sources of vitamin A more effectively inhibit female rat sexual maturation, mammary gland development, and mammary carcinogenesis than retinyl palmitate. In: Journal of Nutrition. 2007 ; Vol. 137, No. 6. pp. 1415-1422.
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abstract = "Previous work using an adolescent rat model for breast cancer showed increased tumor occurrence in rats fed a chemopreventive dose of vitamin A. Preclinical models for nutrient-cancer interactions utilizing defined diets do not replicate the complexity of the human diet and may be inadequate to investigate food patterns associated with reduced cancer risk in humans. To evaluate this concept, the effects of vitamin A on sexual maturation, mammary gland development, and sensitivity to carcinogenesis were determined in the context of a human food-based diet (whole food diet). At 20 d of age (p20), female rats received either a whole-food diet with adequate levels of vitamin A, a diet with a 5.5-fold increase in vitamin A from fruits and vegetables (S diet), or a diet with a 6.2-fold increase in vitamin A provided as retinyl palmitate (RP diet). To determine the effect of dietary intervention on pubertal mammary gland development, the dietary intervention period was restricted to postnatal d 21-63. Rats were injected with 50 mg 1-methyl-1-nitrosourea/kg body weight at d 66. Compared with adolescent rats that consumed the Ad diet, consumption of S and RP diets reduced mammary cancer multiplicity (relative risk 0.7, P ≤ 0.002), which was associated with a reduction in alveolar gland development. The S diet suppressed the onset of sexual maturation (P <0.001) and inhibited markers of mammary alveologenesis more than the RP diet. These data demonstrate that the amount and source of vitamin A consumed by adolescent female rats can influence the onset of puberty, mammary gland alveolar development, and breast cancer risk and highlight the relevance of utilizing whole-food diets to evaluate the role of dietary factors in cancer prevention.",
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