Whole-blood interleukin-18 level during early HIV-1 infection is associated with reduced CXCR4 coreceptor expression and interferon-γ levels

Carrie Sailer, Gregory B. Pott, Charles A. Dinarello, Samantha Ma Whinney, Jeri E. Forster, Jacqueline K. Larson-Duran, Alan Landay, Lena Al-Harthi, Robert T. Schooley, Constance A. Benson, Franklyn N. Judson, Melanie Thompson, Frank J. Palella, Leland Shapiro

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Interleukin (IL)-18 generates T helper 1-type immunity and inhibits human immunodeficiency virus type 1 (HIV-1) in primary cells in vitro. Because IL-18 may participate in HIV-1 containment, whole-blood IL-18 levels were measured in 20 healthy control subjects and longitudinally in 28 subjects with early HIV-1 infection. Compared with those in control subjects, IL-18 levels were higher during early HIV-1 infection, and IL-18 levels predicted reduced CXCR4 HIV-1 coreceptor expression and diminished interferon (IFN)-γ levels. By contrast, a direct association between IL-18 and IFN-γ levels was observed in blood stimulated with lipopolysaccharide. During early HIV-1 infection, IL-18 may regulate HIV-1 coreceptor expression and have antiretroviral activity.

Original languageEnglish (US)
Pages (from-to)734-738
Number of pages5
JournalJournal of Infectious Diseases
Volume195
Issue number5
DOIs
StatePublished - Mar 1 2007
Externally publishedYes

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Interleukin-18
Virus Diseases
Interferons
HIV-1
Lipopolysaccharides
Immunity
Healthy Volunteers

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health
  • Immunology

Cite this

Whole-blood interleukin-18 level during early HIV-1 infection is associated with reduced CXCR4 coreceptor expression and interferon-γ levels. / Sailer, Carrie; Pott, Gregory B.; Dinarello, Charles A.; Whinney, Samantha Ma; Forster, Jeri E.; Larson-Duran, Jacqueline K.; Landay, Alan; Al-Harthi, Lena; Schooley, Robert T.; Benson, Constance A.; Judson, Franklyn N.; Thompson, Melanie; Palella, Frank J.; Shapiro, Leland.

In: Journal of Infectious Diseases, Vol. 195, No. 5, 01.03.2007, p. 734-738.

Research output: Contribution to journalArticle

Sailer, C, Pott, GB, Dinarello, CA, Whinney, SM, Forster, JE, Larson-Duran, JK, Landay, A, Al-Harthi, L, Schooley, RT, Benson, CA, Judson, FN, Thompson, M, Palella, FJ & Shapiro, L 2007, 'Whole-blood interleukin-18 level during early HIV-1 infection is associated with reduced CXCR4 coreceptor expression and interferon-γ levels', Journal of Infectious Diseases, vol. 195, no. 5, pp. 734-738. https://doi.org/10.1086/511435
Sailer, Carrie ; Pott, Gregory B. ; Dinarello, Charles A. ; Whinney, Samantha Ma ; Forster, Jeri E. ; Larson-Duran, Jacqueline K. ; Landay, Alan ; Al-Harthi, Lena ; Schooley, Robert T. ; Benson, Constance A. ; Judson, Franklyn N. ; Thompson, Melanie ; Palella, Frank J. ; Shapiro, Leland. / Whole-blood interleukin-18 level during early HIV-1 infection is associated with reduced CXCR4 coreceptor expression and interferon-γ levels. In: Journal of Infectious Diseases. 2007 ; Vol. 195, No. 5. pp. 734-738.
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