Whole-blood interleukin-18 level during early HIV-1 infection is associated with reduced CXCR4 coreceptor expression and interferon-γ levels

Carrie A. Sailer, Gregory B. Pott, Charles A. Dinarello, Samantha Ma Whinney, Jeri E. Forster, Jacqueline K. Larson-Duran, Alan Landay, Lena Al-Harthi, Robert T. Schooley, Constance A. Benson, Franklyn N. Judson, Melanie Thompson, Frank J. Palella, Leland Shapiro

Research output: Contribution to journalArticlepeer-review

14 Scopus citations

Abstract

Interleukin (IL)-18 generates T helper 1-type immunity and inhibits human immunodeficiency virus type 1 (HIV-1) in primary cells in vitro. Because IL-18 may participate in HIV-1 containment, whole-blood IL-18 levels were measured in 20 healthy control subjects and longitudinally in 28 subjects with early HIV-1 infection. Compared with those in control subjects, IL-18 levels were higher during early HIV-1 infection, and IL-18 levels predicted reduced CXCR4 HIV-1 coreceptor expression and diminished interferon (IFN)-γ levels. By contrast, a direct association between IL-18 and IFN-γ levels was observed in blood stimulated with lipopolysaccharide. During early HIV-1 infection, IL-18 may regulate HIV-1 coreceptor expression and have antiretroviral activity.

Original languageEnglish (US)
Pages (from-to)734-738
Number of pages5
JournalJournal of Infectious Diseases
Volume195
Issue number5
DOIs
StatePublished - Mar 1 2007
Externally publishedYes

ASJC Scopus subject areas

  • Immunology and Allergy
  • Infectious Diseases

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