Whole-blood interleukin-18 level during early HIV-1 infection is associated with reduced CXCR4 coreceptor expression and interferon-γ levels

Carrie A. Sailer, Gregory B. Pott, Charles A. Dinarello, Samantha Ma Whinney, Jeri E. Forster, Jacqueline K. Larson-Duran, Alan Landay, Lena Al-Harthi, Robert T. Schooley, Constance A. Benson, Franklyn N. Judson, Melanie Thompson, Frank J. Palella, Leland Shapiro

Research output: Contribution to journalArticle

14 Scopus citations

Abstract

Interleukin (IL)-18 generates T helper 1-type immunity and inhibits human immunodeficiency virus type 1 (HIV-1) in primary cells in vitro. Because IL-18 may participate in HIV-1 containment, whole-blood IL-18 levels were measured in 20 healthy control subjects and longitudinally in 28 subjects with early HIV-1 infection. Compared with those in control subjects, IL-18 levels were higher during early HIV-1 infection, and IL-18 levels predicted reduced CXCR4 HIV-1 coreceptor expression and diminished interferon (IFN)-γ levels. By contrast, a direct association between IL-18 and IFN-γ levels was observed in blood stimulated with lipopolysaccharide. During early HIV-1 infection, IL-18 may regulate HIV-1 coreceptor expression and have antiretroviral activity.

Original languageEnglish (US)
Pages (from-to)734-738
Number of pages5
JournalJournal of Infectious Diseases
Volume195
Issue number5
DOIs
StatePublished - Mar 1 2007

ASJC Scopus subject areas

  • Immunology and Allergy
  • Infectious Diseases

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    Sailer, C. A., Pott, G. B., Dinarello, C. A., Whinney, S. M., Forster, J. E., Larson-Duran, J. K., Landay, A., Al-Harthi, L., Schooley, R. T., Benson, C. A., Judson, F. N., Thompson, M., Palella, F. J., & Shapiro, L. (2007). Whole-blood interleukin-18 level during early HIV-1 infection is associated with reduced CXCR4 coreceptor expression and interferon-γ levels. Journal of Infectious Diseases, 195(5), 734-738. https://doi.org/10.1086/511435