Whole blood interferon-gamma responses to Mycobacterium tuberculosis antigens in young household contacts of persons with tuberculosis in Uganda

Deborah Lewinsohn, Sarah Zalwango, Catherine M. Stein, Harriet Mayanja-Kizza, Alphonse Okwera, W. Henry Boom, Roy D. Mugerwa, Christopher C. Whalen

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35 Scopus citations

Abstract

Background: Due to immunologic immaturity, IFN-γ-producing T cell responses may be decreased in young children compared to adults, thus we hypothesized that IFN-γ responses to mycobacterial antigens in household contacts exposed to Mycobacterium tuberculosis (Mtb) would be impaired in young children relative to adults. The objective of this study was to compare whole blood IFN-γ production in response to mycobacterial antigens between children and adults in Uganda. Methodology/Principal Findings: We studied household contacts of persons with culture-positive pulmonary tuberculosis (TB) enrolled in a cohort study conducted in Kampala, Uganda. Whole blood IFN-γ production in response to Mtb culture-filtrate antigens was measured by ELISA and compared between infants (

Original languageEnglish (US)
Article numbere3407
JournalPLoS One
Volume3
Issue number10
DOIs
Publication statusPublished - Oct 15 2008

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ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

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