Whole blood ω-3 fatty acids are inversely associated with carotid intima-media thickness in indigenous mexican women

Adriana Monge, William Harris, Eduardo Ortiz-Panozo, Elsa Yunes, Carlos Cantu-Brito, Andres Catzin-Kuhlmann, Ruy López-Ridaura, Martín Lajous

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Background: Long-chain ω-3 (n-3) polyunsaturated fatty acids (PUFAs) may reduce the risk of atherosclerosis. The association between n-3 PUFAs and cardiovascular disease may vary across different populations, and there is limited information on Hispanic individuals with mixed Amerindian and European origin. Objective: Weevaluated the cross-sectional relations between whole blood n-3 PUFAs and carotid intima-media thickness (IMT) in Mexican women living in Mexico and assessed whether this relation was different in women who spoke an indigenous language compared with women who did not. Methods: In 2012-2013, we assessed the association between blood n-3 PUFAs and IMT in 1306 women free of disease in Chiapas and Yucatan, Mexico. We categorized blood n-3 PUFAs (% of total FAs) in quartiles and adjusted linear regression models by age, indigenous language, site, socioeconomic status, education, smoking, menopause, diabetes, hypertension, hypercholesterolemia, body mass index, physical activity, and diet. We stratified analyses by indigenous/ nonindigenous language speakers (n = 315 of 991). Results: Whole blood n-3 PUFAs (means ± SDs) were 3.58% 6 0.78% of total FAs. We did not observe a significant association between n-3 PUFAs and IMT in the overall study population. However, the adjusted mean difference of IMT was26.5% (95% CI:210.7%,22.3%; P-trend < 0.0001) for indigenous women in the highest quartile compared with the lowest quartile of blood n-3 PUFAs. In nonindigenous women, we did not observe an association (20.6%; 95% CI: 23.0%, 1.8%, comparing extreme quartiles; P-trend = 1.00). Conclusions: Overall, circulating n-3 PUFAs were not associated with IMT. However, we observed a strong statistically significant inverse association with IMT in indigenous Mexican women. Future studies should evaluate genetic markers that may reflect differences in n-3 PUFA metabolism across populations.

Original languageEnglish (US)
Pages (from-to)1365-1372
Number of pages8
JournalJournal of Nutrition
Volume146
Issue number7
DOIs
StatePublished - 2016
Externally publishedYes

Fingerprint

Carotid Intima-Media Thickness
Omega-3 Fatty Acids
Fatty Acids
Language
Mexico
Linear Models
Population
Menopause
Hypercholesterolemia
Genetic Markers
Hispanic Americans
Social Class
Atherosclerosis
Body Mass Index
Cardiovascular Diseases
Smoking
Exercise
Diet
Hypertension
Education

Keywords

  • Cross sectional
  • Indigenous
  • Intima-media thickness
  • Mexican women
  • N-3 PUFA metabolism

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Medicine(all)
  • Nutrition and Dietetics

Cite this

Monge, A., Harris, W., Ortiz-Panozo, E., Yunes, E., Cantu-Brito, C., Catzin-Kuhlmann, A., ... Lajous, M. (2016). Whole blood ω-3 fatty acids are inversely associated with carotid intima-media thickness in indigenous mexican women. Journal of Nutrition, 146(7), 1365-1372. https://doi.org/10.3945/jn.115.227264

Whole blood ω-3 fatty acids are inversely associated with carotid intima-media thickness in indigenous mexican women. / Monge, Adriana; Harris, William; Ortiz-Panozo, Eduardo; Yunes, Elsa; Cantu-Brito, Carlos; Catzin-Kuhlmann, Andres; López-Ridaura, Ruy; Lajous, Martín.

In: Journal of Nutrition, Vol. 146, No. 7, 2016, p. 1365-1372.

Research output: Contribution to journalArticle

Monge, A, Harris, W, Ortiz-Panozo, E, Yunes, E, Cantu-Brito, C, Catzin-Kuhlmann, A, López-Ridaura, R & Lajous, M 2016, 'Whole blood ω-3 fatty acids are inversely associated with carotid intima-media thickness in indigenous mexican women', Journal of Nutrition, vol. 146, no. 7, pp. 1365-1372. https://doi.org/10.3945/jn.115.227264
Monge, Adriana ; Harris, William ; Ortiz-Panozo, Eduardo ; Yunes, Elsa ; Cantu-Brito, Carlos ; Catzin-Kuhlmann, Andres ; López-Ridaura, Ruy ; Lajous, Martín. / Whole blood ω-3 fatty acids are inversely associated with carotid intima-media thickness in indigenous mexican women. In: Journal of Nutrition. 2016 ; Vol. 146, No. 7. pp. 1365-1372.
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abstract = "Background: Long-chain ω-3 (n-3) polyunsaturated fatty acids (PUFAs) may reduce the risk of atherosclerosis. The association between n-3 PUFAs and cardiovascular disease may vary across different populations, and there is limited information on Hispanic individuals with mixed Amerindian and European origin. Objective: Weevaluated the cross-sectional relations between whole blood n-3 PUFAs and carotid intima-media thickness (IMT) in Mexican women living in Mexico and assessed whether this relation was different in women who spoke an indigenous language compared with women who did not. Methods: In 2012-2013, we assessed the association between blood n-3 PUFAs and IMT in 1306 women free of disease in Chiapas and Yucatan, Mexico. We categorized blood n-3 PUFAs ({\%} of total FAs) in quartiles and adjusted linear regression models by age, indigenous language, site, socioeconomic status, education, smoking, menopause, diabetes, hypertension, hypercholesterolemia, body mass index, physical activity, and diet. We stratified analyses by indigenous/ nonindigenous language speakers (n = 315 of 991). Results: Whole blood n-3 PUFAs (means ± SDs) were 3.58{\%} 6 0.78{\%} of total FAs. We did not observe a significant association between n-3 PUFAs and IMT in the overall study population. However, the adjusted mean difference of IMT was26.5{\%} (95{\%} CI:210.7{\%},22.3{\%}; P-trend < 0.0001) for indigenous women in the highest quartile compared with the lowest quartile of blood n-3 PUFAs. In nonindigenous women, we did not observe an association (20.6{\%}; 95{\%} CI: 23.0{\%}, 1.8{\%}, comparing extreme quartiles; P-trend = 1.00). Conclusions: Overall, circulating n-3 PUFAs were not associated with IMT. However, we observed a strong statistically significant inverse association with IMT in indigenous Mexican women. Future studies should evaluate genetic markers that may reflect differences in n-3 PUFA metabolism across populations.",
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AU - Monge, Adriana

AU - Harris, William

AU - Ortiz-Panozo, Eduardo

AU - Yunes, Elsa

AU - Cantu-Brito, Carlos

AU - Catzin-Kuhlmann, Andres

AU - López-Ridaura, Ruy

AU - Lajous, Martín

PY - 2016

Y1 - 2016

N2 - Background: Long-chain ω-3 (n-3) polyunsaturated fatty acids (PUFAs) may reduce the risk of atherosclerosis. The association between n-3 PUFAs and cardiovascular disease may vary across different populations, and there is limited information on Hispanic individuals with mixed Amerindian and European origin. Objective: Weevaluated the cross-sectional relations between whole blood n-3 PUFAs and carotid intima-media thickness (IMT) in Mexican women living in Mexico and assessed whether this relation was different in women who spoke an indigenous language compared with women who did not. Methods: In 2012-2013, we assessed the association between blood n-3 PUFAs and IMT in 1306 women free of disease in Chiapas and Yucatan, Mexico. We categorized blood n-3 PUFAs (% of total FAs) in quartiles and adjusted linear regression models by age, indigenous language, site, socioeconomic status, education, smoking, menopause, diabetes, hypertension, hypercholesterolemia, body mass index, physical activity, and diet. We stratified analyses by indigenous/ nonindigenous language speakers (n = 315 of 991). Results: Whole blood n-3 PUFAs (means ± SDs) were 3.58% 6 0.78% of total FAs. We did not observe a significant association between n-3 PUFAs and IMT in the overall study population. However, the adjusted mean difference of IMT was26.5% (95% CI:210.7%,22.3%; P-trend < 0.0001) for indigenous women in the highest quartile compared with the lowest quartile of blood n-3 PUFAs. In nonindigenous women, we did not observe an association (20.6%; 95% CI: 23.0%, 1.8%, comparing extreme quartiles; P-trend = 1.00). Conclusions: Overall, circulating n-3 PUFAs were not associated with IMT. However, we observed a strong statistically significant inverse association with IMT in indigenous Mexican women. Future studies should evaluate genetic markers that may reflect differences in n-3 PUFA metabolism across populations.

AB - Background: Long-chain ω-3 (n-3) polyunsaturated fatty acids (PUFAs) may reduce the risk of atherosclerosis. The association between n-3 PUFAs and cardiovascular disease may vary across different populations, and there is limited information on Hispanic individuals with mixed Amerindian and European origin. Objective: Weevaluated the cross-sectional relations between whole blood n-3 PUFAs and carotid intima-media thickness (IMT) in Mexican women living in Mexico and assessed whether this relation was different in women who spoke an indigenous language compared with women who did not. Methods: In 2012-2013, we assessed the association between blood n-3 PUFAs and IMT in 1306 women free of disease in Chiapas and Yucatan, Mexico. We categorized blood n-3 PUFAs (% of total FAs) in quartiles and adjusted linear regression models by age, indigenous language, site, socioeconomic status, education, smoking, menopause, diabetes, hypertension, hypercholesterolemia, body mass index, physical activity, and diet. We stratified analyses by indigenous/ nonindigenous language speakers (n = 315 of 991). Results: Whole blood n-3 PUFAs (means ± SDs) were 3.58% 6 0.78% of total FAs. We did not observe a significant association between n-3 PUFAs and IMT in the overall study population. However, the adjusted mean difference of IMT was26.5% (95% CI:210.7%,22.3%; P-trend < 0.0001) for indigenous women in the highest quartile compared with the lowest quartile of blood n-3 PUFAs. In nonindigenous women, we did not observe an association (20.6%; 95% CI: 23.0%, 1.8%, comparing extreme quartiles; P-trend = 1.00). Conclusions: Overall, circulating n-3 PUFAs were not associated with IMT. However, we observed a strong statistically significant inverse association with IMT in indigenous Mexican women. Future studies should evaluate genetic markers that may reflect differences in n-3 PUFA metabolism across populations.

KW - Cross sectional

KW - Indigenous

KW - Intima-media thickness

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KW - N-3 PUFA metabolism

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