Who is the better donor for older hematopoietic transplant recipients: an older-aged sibling or a young, matched unrelated volunteer?

Amin M. Alousi, Jennifer Le-Rademacher, Rima M. Saliba, Frederick R. Appelbaum, Andrew Artz, Jonathan Benjamin, Steven M. Devine, Fangyu Kan, Mary J. Laughlin, Hillard M. Lazarus, Jane Liesveld, Miguel Angel Perales, Richard Maziarz, Mitchell Sabloff, Edmund K. Waller, Mary Eapen, Richard E. Champlin

Research output: Contribution to journalArticle

62 Citations (Scopus)

Abstract

Older patients are increasingly undergoing allogeneic hematopoietic transplantation. A relevant question is whether outcomes can be improved with a younger allele-level 8/8 HLA-matched unrelated donor (MUD) rather than an older HLA-matched sibling (MSD). Accordingly, transplants in leukemia/lymphoma patients age ≥50 years were analyzed comparing outcomes for recipients of MSD ≥50 (n = 1415) versus MUD

Original languageEnglish (US)
Pages (from-to)2567-2573
Number of pages7
JournalBlood
Volume121
Issue number13
DOIs
StatePublished - Mar 28 2013

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Unrelated Donors
Transplants
Siblings
Volunteers
Tissue Donors
Homologous Transplantation
Lymphoma
Leukemia
Alleles
Transplant Recipients

ASJC Scopus subject areas

  • Hematology
  • Biochemistry
  • Cell Biology
  • Immunology

Cite this

Alousi, A. M., Le-Rademacher, J., Saliba, R. M., Appelbaum, F. R., Artz, A., Benjamin, J., ... Champlin, R. E. (2013). Who is the better donor for older hematopoietic transplant recipients: an older-aged sibling or a young, matched unrelated volunteer? Blood, 121(13), 2567-2573. https://doi.org/10.1182/blood-2012-08-453860

Who is the better donor for older hematopoietic transplant recipients : an older-aged sibling or a young, matched unrelated volunteer? / Alousi, Amin M.; Le-Rademacher, Jennifer; Saliba, Rima M.; Appelbaum, Frederick R.; Artz, Andrew; Benjamin, Jonathan; Devine, Steven M.; Kan, Fangyu; Laughlin, Mary J.; Lazarus, Hillard M.; Liesveld, Jane; Perales, Miguel Angel; Maziarz, Richard; Sabloff, Mitchell; Waller, Edmund K.; Eapen, Mary; Champlin, Richard E.

In: Blood, Vol. 121, No. 13, 28.03.2013, p. 2567-2573.

Research output: Contribution to journalArticle

Alousi, AM, Le-Rademacher, J, Saliba, RM, Appelbaum, FR, Artz, A, Benjamin, J, Devine, SM, Kan, F, Laughlin, MJ, Lazarus, HM, Liesveld, J, Perales, MA, Maziarz, R, Sabloff, M, Waller, EK, Eapen, M & Champlin, RE 2013, 'Who is the better donor for older hematopoietic transplant recipients: an older-aged sibling or a young, matched unrelated volunteer?', Blood, vol. 121, no. 13, pp. 2567-2573. https://doi.org/10.1182/blood-2012-08-453860
Alousi, Amin M. ; Le-Rademacher, Jennifer ; Saliba, Rima M. ; Appelbaum, Frederick R. ; Artz, Andrew ; Benjamin, Jonathan ; Devine, Steven M. ; Kan, Fangyu ; Laughlin, Mary J. ; Lazarus, Hillard M. ; Liesveld, Jane ; Perales, Miguel Angel ; Maziarz, Richard ; Sabloff, Mitchell ; Waller, Edmund K. ; Eapen, Mary ; Champlin, Richard E. / Who is the better donor for older hematopoietic transplant recipients : an older-aged sibling or a young, matched unrelated volunteer?. In: Blood. 2013 ; Vol. 121, No. 13. pp. 2567-2573.
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