TY - JOUR
T1 - Who is at risk? Population characterization of alcohol self-administration in nonhuman primates helps identify pathways to dependence
AU - Grant, Kathleen A.
AU - Stafford, James
AU - Thiede, Allison
AU - Kiley, Caitlin
AU - Odagiri, Misa
AU - Ferguson, Betsy
PY - 2008
Y1 - 2008
N2 - Alcohol abuse and dependence are human conditions for which no full equivalent exists in animals. Nevertheless, animal models frequently are used to study various aspects of alcohol dependence that cannot be easily or ethically assessed in humans, including neurobiological mechanisms underlying alcohol dependence. Many of these animal models involve rodents; however, the characteristics (i.e., phenotypes) of chronic heavy drinking may be limited in these species. Nonhuman primates add an important translational aspect to the study of alcohol abuse and alcoholism. Their genetic, anatomical, physiological, and behavioral similarity to humans offers unique opportunities for identifying risk factors that may predispose a person to or accelerate the course of alcohol addiction. Studying alcohol consumption in nonhuman primates, including the distribution of drinking levels in a population, also can be uniquely informative to alcohol research. For example, research on the self-administration procedures in primates can help scientists identify risk factors for excessive alcohol consumption in humans. The phenotype of excessive drinking then can serve as the starting point to test and verify the underlying genetic and environmental influences. The resulting findings, in turn, can help guide prevention and treatment strategies.
AB - Alcohol abuse and dependence are human conditions for which no full equivalent exists in animals. Nevertheless, animal models frequently are used to study various aspects of alcohol dependence that cannot be easily or ethically assessed in humans, including neurobiological mechanisms underlying alcohol dependence. Many of these animal models involve rodents; however, the characteristics (i.e., phenotypes) of chronic heavy drinking may be limited in these species. Nonhuman primates add an important translational aspect to the study of alcohol abuse and alcoholism. Their genetic, anatomical, physiological, and behavioral similarity to humans offers unique opportunities for identifying risk factors that may predispose a person to or accelerate the course of alcohol addiction. Studying alcohol consumption in nonhuman primates, including the distribution of drinking levels in a population, also can be uniquely informative to alcohol research. For example, research on the self-administration procedures in primates can help scientists identify risk factors for excessive alcohol consumption in humans. The phenotype of excessive drinking then can serve as the starting point to test and verify the underlying genetic and environmental influences. The resulting findings, in turn, can help guide prevention and treatment strategies.
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M3 - Review article
C2 - 23584006
AN - SCOPUS:85003340107
SN - 2168-3492
VL - 31
SP - 289
EP - 297
JO - Alcohol research & health : the journal of the National Institute on Alcohol Abuse and Alcoholism
JF - Alcohol research & health : the journal of the National Institute on Alcohol Abuse and Alcoholism
IS - 4
ER -