What is a pericyte?

David Attwell, Anusha Mishra, Catherine N. Hall, Fergus M. O'Farrell, Turgay Dalkara

Research output: Contribution to journalArticle

152 Scopus citations

Abstract

Pericytes, spatially isolated contractile cells on capillaries, have been reported to control cerebral blood flow physiologically, and to limit blood flow after ischaemia by constricting capillaries and then dying. Paradoxically, a recent paper dismisses the idea of pericytes controlling cerebral blood flow, despite confirming earlier data showing a role for pericytes. We show that these discrepancies are apparent rather than real, and depend on the new paper defining pericytes differently from previous reports. An objective definition of different sub-classes of pericyte along the capillary bed is needed to develop novel therapeutic approaches for stroke and disorders caused by pericyte malfunction.

Original languageEnglish (US)
Pages (from-to)451-455
Number of pages5
JournalJournal of Cerebral Blood Flow and Metabolism
Volume36
Issue number2
DOIs
Publication statusPublished - Feb 1 2016
Externally publishedYes

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Keywords

  • blood-brain barrier
  • capillary
  • cerebral blood flow
  • Pericyte
  • stroke

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Clinical Neurology
  • Neurology

Cite this

Attwell, D., Mishra, A., Hall, C. N., O'Farrell, F. M., & Dalkara, T. (2016). What is a pericyte? Journal of Cerebral Blood Flow and Metabolism, 36(2), 451-455. https://doi.org/10.1177/0271678X15610340