TY - JOUR
T1 - What happened to the US cancer cooperative groups? A status update ten years after the Institute of Medicine report
AU - Bertagnolli, Monica M.
AU - Blanke, Charles D.
AU - Curran, Walter J.
AU - Hawkins, Douglas S.
AU - Mannel, Robert S.
AU - O’Dwyer, Peter J.
AU - Schnall, Mitchell D.
AU - Wolmark, Norman
N1 - Publisher Copyright:
© 2020 American Cancer Society
PY - 2020/12/1
Y1 - 2020/12/1
N2 - The US cancer cooperative groups (cooperative groups) were founded in the 1950s to establish a standing infrastructure to conduct multi-institutional cancer clinical trials. Initially funded almost entirely by the US National Cancer Institute (NCI), over the years, the research conducted by the Cooperative Groups has evolved to meet the demands of cancer clinical research, with a scope now encompassing trials to advance cancer treatment, cancer control, biomarker development and validation, and health services research, with a corresponding broadening of their funding sources. The cooperative groups are also a critical mechanism for educating the next generation of cancer clinical trialists from many different disciplines. This review outlines the overall mission, structure, and funding of the cooperative groups, beginning in 1955 when they were first established by the NCI, and describes the considerable progress against cancer achieved over the past decade.
AB - The US cancer cooperative groups (cooperative groups) were founded in the 1950s to establish a standing infrastructure to conduct multi-institutional cancer clinical trials. Initially funded almost entirely by the US National Cancer Institute (NCI), over the years, the research conducted by the Cooperative Groups has evolved to meet the demands of cancer clinical research, with a scope now encompassing trials to advance cancer treatment, cancer control, biomarker development and validation, and health services research, with a corresponding broadening of their funding sources. The cooperative groups are also a critical mechanism for educating the next generation of cancer clinical trialists from many different disciplines. This review outlines the overall mission, structure, and funding of the cooperative groups, beginning in 1955 when they were first established by the NCI, and describes the considerable progress against cancer achieved over the past decade.
KW - NCI Community Oncology Research Program (NCORP)
KW - NCI National Clinical Trials Network (NCTN)
KW - National Cancer Institute (NCI)
KW - cancer clinical trials
KW - cooperative groups
UR - http://www.scopus.com/inward/record.url?scp=85091382567&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85091382567&partnerID=8YFLogxK
U2 - 10.1002/cncr.33209
DO - 10.1002/cncr.33209
M3 - Review article
C2 - 32970346
AN - SCOPUS:85091382567
SN - 0008-543X
VL - 126
SP - 5022
EP - 5029
JO - Cancer
JF - Cancer
IS - 23
ER -