What Does It Take to Demonstrate Memory Erasure? Theoretical Comment on Norrholm et al. (2008)

Kennon (Matt) Lattal, James M. Stafford

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

An issue of increasing interest in Pavlovian conditioning is to identify ways to facilitate the development and persistence of extinction. Both behavioral and molecular lines of evidence demonstrate that learning during extinction can be enhanced. Similar evidence has been offered to support the idea that extinction causes the original association to be unlearned, or erased. Differentiating between extinction and erasure accounts is extremely difficult and requires many assumptions about the fundamental nature of how memory storage maps into memory expression. In this issue of Behavioral Neuroscience, Norrholm et al. (2008) describe a study of extinction with humans that has the potential to serve as a translational bridge between rodent work and clinical applications. They find less recovery of a conditioned fear response when extinction occurs 10 min compared with 72 hr after conditioning; however, the recovery of subjects' expectancies of the fearful stimulus is independent of when extinction occurred. These findings and others discussed in this article demonstrate some of the challenges in making inferences about memory erasure during extinction.

Original languageEnglish (US)
Pages (from-to)1186-1190
Number of pages5
JournalBehavioral Neuroscience
Volume122
Issue number5
DOIs
StatePublished - Oct 2008

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Psychological Extinction
Neurosciences
Fear
Rodentia
Learning
Conditioning (Psychology)

Keywords

  • consolidation
  • extinction
  • memory erasure
  • memory storage
  • reconsolidation

ASJC Scopus subject areas

  • Behavioral Neuroscience

Cite this

What Does It Take to Demonstrate Memory Erasure? Theoretical Comment on Norrholm et al. (2008). / Lattal, Kennon (Matt); Stafford, James M.

In: Behavioral Neuroscience, Vol. 122, No. 5, 10.2008, p. 1186-1190.

Research output: Contribution to journalArticle

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