TY - JOUR
T1 - What colour are newborns' eyes? Prevalence of iris colour in the Newborn Eye Screening Test (NEST) study
AU - Ludwig, Cassie A.
AU - Callaway, Natalia F.
AU - Fredrick, Douglas R.
AU - Blumenkranz, Mark S.
AU - Moshfeghi, Darius M.
N1 - Publisher Copyright:
© 2016 Acta Ophthalmologica Scandinavica Foundation. Published by John Wiley & Sons Ltd
PY - 2016/8/1
Y1 - 2016/8/1
N2 - Purpose: This study aims to assess the birth prevalence of iris colour among newborns in a prospective, healthy, full-term newborn cohort. Methods: The Newborn Eye Screening Test (NEST) study is a prospective cohort study conducted at Lucile Packard Children's Hospital at Stanford University School of Medicine. A paediatric vitreoretinal specialist (DMM) reviewed images sent to the Byers Eye Institute telemedicine reading centre and recorded eye colour for every infant screened. Variables were graphed to assess for normality, and frequencies per subject were reported for eye colour, sex, ethnicity and race. Results: Among 192 subjects screened in the first year of the NEST study with external images of appropriate quality for visualization of the irides, the birth prevalence of iris colour was 63.0% brown, 20.8% blue, 5.7% green/hazel, 9.9% indeterminate and 0.5% partial heterochromia. The study population was derived from a quaternary care children's hospital. We report the birth prevalence of iris colour among full-term newborns in a diverse prospective cohort. Conclusion: The study demonstrates a broad range of iris colour prevalence at birth with a predominance of brown iris coloration. Future studies with the NEST cohort will assess the change in iris colour over time and whether the frequencies of eye colour change as the child ages.
AB - Purpose: This study aims to assess the birth prevalence of iris colour among newborns in a prospective, healthy, full-term newborn cohort. Methods: The Newborn Eye Screening Test (NEST) study is a prospective cohort study conducted at Lucile Packard Children's Hospital at Stanford University School of Medicine. A paediatric vitreoretinal specialist (DMM) reviewed images sent to the Byers Eye Institute telemedicine reading centre and recorded eye colour for every infant screened. Variables were graphed to assess for normality, and frequencies per subject were reported for eye colour, sex, ethnicity and race. Results: Among 192 subjects screened in the first year of the NEST study with external images of appropriate quality for visualization of the irides, the birth prevalence of iris colour was 63.0% brown, 20.8% blue, 5.7% green/hazel, 9.9% indeterminate and 0.5% partial heterochromia. The study population was derived from a quaternary care children's hospital. We report the birth prevalence of iris colour among full-term newborns in a diverse prospective cohort. Conclusion: The study demonstrates a broad range of iris colour prevalence at birth with a predominance of brown iris coloration. Future studies with the NEST cohort will assess the change in iris colour over time and whether the frequencies of eye colour change as the child ages.
KW - eye colour
KW - newborns
KW - paediatric ophthalmology
KW - prevalence
KW - universal newborn screening
UR - http://www.scopus.com/inward/record.url?scp=84978976672&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84978976672&partnerID=8YFLogxK
U2 - 10.1111/aos.13006
DO - 10.1111/aos.13006
M3 - Article
C2 - 27061128
AN - SCOPUS:84978976672
SN - 1755-375X
VL - 94
SP - 485
EP - 488
JO - Acta ophthalmologica
JF - Acta ophthalmologica
IS - 5
ER -