Western-style diet, with and without chronic androgen treatment, alters the number, structure, and function of small antral follicles in ovaries of young adult monkeys

Cecily Bishop, Fuhua Xu, Jing Xu, Alison Ting, Etienne Galbreath, Whitney K. McGee, Mary Zelinski, Jon Hennebold, Judy L. Cameron, Richard Stouffer

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Objective: To examine the small antral follicle (SAF) cohort in ovaries of adult rhesus monkeys after consumption of a Western-style diet (WSD), with or without chronically elevated androgen levels since before puberty. Design: Cholesterol or T (n = 6 per group) implants were placed SC in female rhesus macaques beginning at 1 year of age (prepubertal), with addition of a WSD (high fat/fructose) at 5.5 years (menarche approximately 2.6 years). Ovaries were collected at 7 years of age. One ovary per female was embedded in paraffin for morphologic and immunohistochemical analyses. The SAFs (

Original languageEnglish (US)
JournalFertility and Sterility
DOIs
StateAccepted/In press - Aug 28 2015

Fingerprint

Androgens
Haplorhini
Young Adult
Ovary
Diet
Macaca mulatta
Menarche
High Fat Diet
Puberty
Fructose
Paraffin
Therapeutics
Cholesterol
Antral
Syntex adjuvant formulation

Keywords

  • Androgen
  • Metabolism
  • Ovarian function
  • Small antral follicles
  • Western-style diet

ASJC Scopus subject areas

  • Obstetrics and Gynecology
  • Reproductive Medicine

Cite this

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abstract = "Objective: To examine the small antral follicle (SAF) cohort in ovaries of adult rhesus monkeys after consumption of a Western-style diet (WSD), with or without chronically elevated androgen levels since before puberty. Design: Cholesterol or T (n = 6 per group) implants were placed SC in female rhesus macaques beginning at 1 year of age (prepubertal), with addition of a WSD (high fat/fructose) at 5.5 years (menarche approximately 2.6 years). Ovaries were collected at 7 years of age. One ovary per female was embedded in paraffin for morphologic and immunohistochemical analyses. The SAFs (",
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T1 - Western-style diet, with and without chronic androgen treatment, alters the number, structure, and function of small antral follicles in ovaries of young adult monkeys

AU - Bishop, Cecily

AU - Xu, Fuhua

AU - Xu, Jing

AU - Ting, Alison

AU - Galbreath, Etienne

AU - McGee, Whitney K.

AU - Zelinski, Mary

AU - Hennebold, Jon

AU - Cameron, Judy L.

AU - Stouffer, Richard

PY - 2015/8/28

Y1 - 2015/8/28

N2 - Objective: To examine the small antral follicle (SAF) cohort in ovaries of adult rhesus monkeys after consumption of a Western-style diet (WSD), with or without chronically elevated androgen levels since before puberty. Design: Cholesterol or T (n = 6 per group) implants were placed SC in female rhesus macaques beginning at 1 year of age (prepubertal), with addition of a WSD (high fat/fructose) at 5.5 years (menarche approximately 2.6 years). Ovaries were collected at 7 years of age. One ovary per female was embedded in paraffin for morphologic and immunohistochemical analyses. The SAFs (

AB - Objective: To examine the small antral follicle (SAF) cohort in ovaries of adult rhesus monkeys after consumption of a Western-style diet (WSD), with or without chronically elevated androgen levels since before puberty. Design: Cholesterol or T (n = 6 per group) implants were placed SC in female rhesus macaques beginning at 1 year of age (prepubertal), with addition of a WSD (high fat/fructose) at 5.5 years (menarche approximately 2.6 years). Ovaries were collected at 7 years of age. One ovary per female was embedded in paraffin for morphologic and immunohistochemical analyses. The SAFs (

KW - Androgen

KW - Metabolism

KW - Ovarian function

KW - Small antral follicles

KW - Western-style diet

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