Western-style diet, with and without chronic androgen treatment, alters the number, structure, and function of small antral follicles in ovaries of young adult monkeys

Cecily Bishop, Fuhua Xu, Jing Xu, Alison Ting, Etienne Galbreath, Whitney K. McGee, Mary Zelinski, Jon Hennebold, Judy L. Cameron, Richard Stouffer

Research output: Contribution to journalArticle

5 Scopus citations

Abstract

Objective: To examine the small antral follicle (SAF) cohort in ovaries of adult rhesus monkeys after consumption of a Western-style diet (WSD), with or without chronically elevated androgen levels since before puberty. Design: Cholesterol or T (n = 6 per group) implants were placed SC in female rhesus macaques beginning at 1 year of age (prepubertal), with addition of a WSD (high fat/fructose) at 5.5 years (menarche approximately 2.6 years). Ovaries were collected at 7 years of age. One ovary per female was embedded in paraffin for morphologic and immunohistochemical analyses. The SAFs (

Original languageEnglish (US)
JournalFertility and Sterility
DOIs
StateAccepted/In press - Aug 28 2015

Keywords

  • Androgen
  • Metabolism
  • Ovarian function
  • Small antral follicles
  • Western-style diet

ASJC Scopus subject areas

  • Obstetrics and Gynecology
  • Reproductive Medicine

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