'Well-differentiated' lymphocytic neoplasms. Immunologic findings correlated with clinical presentation and morphologic features

L. J. Medeiros, J. G. Strickler, Louis Picker, A. B. Gelb, L. M. Weiss, R. A. Warnke

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Abstract

The authors studied 48 cases of well-differentiated lymphocytic neoplasms using a panel of monoclonal antibodies applied to frozen sections. Forty-seven tumors expressed monotypic immunoglobulin, one or more B-lineage antigens, and Ia (HLA-DR) antigen. Proliferation centers expressed the T9 antigen and increased numbers of Ki-67-positive cells. One tumor was of T-cell origin, had a cytotoxic/suppressor cell phenotype, and showed anomalous loss of Leu-1 antigen. Immunophenotypic findings were correlated to the clinical presentation and morphologic features of each neoplasm. Sixteen tumors were associated with peripheral lymphocytosis (>4000/cu mm), 13 biopsies were obtained from extranodal sites, 16 tumors had proliferation centers, and 11 neoplasms had plasmacytoid features. The authors found no absolute and few statistically significant immunologic differences between the B-cell tumors according to their clinical presentation or morphologic features. Tumors associated with peripheral lymphocytosis more commonly expressed the Leu-1 antigen (P

Original languageEnglish (US)
Pages (from-to)523-535
Number of pages13
JournalAmerican Journal of Pathology
Volume129
Issue number3
StatePublished - 1987
Externally publishedYes

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Neoplasms
CD5 Antigens
Lymphocytosis
Histocompatibility Antigens Class II
Frozen Sections
HLA-DR Antigens
Immunoglobulins
B-Lymphocytes
Monoclonal Antibodies
T-Lymphocytes
Phenotype
Biopsy
Antigens

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

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'Well-differentiated' lymphocytic neoplasms. Immunologic findings correlated with clinical presentation and morphologic features. / Medeiros, L. J.; Strickler, J. G.; Picker, Louis; Gelb, A. B.; Weiss, L. M.; Warnke, R. A.

In: American Journal of Pathology, Vol. 129, No. 3, 1987, p. 523-535.

Research output: Contribution to journalArticle

Medeiros, L. J. ; Strickler, J. G. ; Picker, Louis ; Gelb, A. B. ; Weiss, L. M. ; Warnke, R. A. / 'Well-differentiated' lymphocytic neoplasms. Immunologic findings correlated with clinical presentation and morphologic features. In: American Journal of Pathology. 1987 ; Vol. 129, No. 3. pp. 523-535.
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AU - Weiss, L. M.

AU - Warnke, R. A.

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