Weight loss, saline loading, and the natriuretic peptide system

Pankaj Arora, Jason Reingold, Aaron Baggish, Derek P. Guanaga, Connie Wu, Anahita Ghorbani, Yanna Song, Annabel Chen-Tournaux, Abigail Khan, Laurel T. Tainsh, Emmanuel S. Buys, Jonathan S. Williams, Denise M. Heublein, John C. Burnett, Marc J. Semigran, Kenneth D. Bloch, Marielle Scherrer-Crosbie, Christopher Newton-Cheh, Lee M. Kaplan, Thomas J. Wang

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

BACKGROUND: In epidemiologic studies, obesity has been associated with reduced natriuretic peptide (NP) concentrations. Reduced NP production could impair the ability of obese individuals to respond to salt loads, increasing the risk of hypertension and other disorders. We hypothesized that weight loss enhances NP production before and after salt loading.

METHODS AND RESULTS: We enrolled 15 obese individuals (mean BMI 45±5.4 kg/m(2)) undergoing gastric bypass surgery. Before and 6 months after surgery, subjects were admitted to the clinical research center and administered a large-volume intravenous saline challenge. Echocardiography and serial blood sampling were performed. From the pre-operative visit to 6 months after surgery, subjects had a mean BMI decrease of 27%. At the 6-month visit, N-terminal pro-atrial NP (Nt-proANP) levels were 40% higher before, during, and after the saline infusion, compared with levels measured at the same time points during the pre-operative visit (P<0.001). The rise in Nt-pro-ANP induced by the saline infusion (≈50%) was similar both before and after surgery (saline, P<0.001; interaction, P=0.2). Similar results were obtained for BNP and Nt-proBNP; resting concentrations increased by 50% and 31%, respectively, after gastric bypass surgery. The increase in NP concentrations after surgery was accompanied by significant decreases in mean arterial pressure (P=0.004) and heart rate (P<0.001), and an increase in mitral annular diastolic velocity (P=0.02).

CONCLUSION: In obese individuals, weight loss is associated with a substantial increase in the "setpoint" of circulating NP concentrations. Higher NP concentrations could contribute to an enhanced ability to handle salt loads after weight loss.

Original languageEnglish (US)
Pages (from-to)e001265
JournalJournal of the American Heart Association
Volume4
Issue number1
DOIs
StatePublished - Jan 16 2015
Externally publishedYes

Fingerprint

Natriuretic Peptides
Weight Loss
Gastric Bypass
Salts
Atrial Natriuretic Factor
Echocardiography
Epidemiologic Studies
Arterial Pressure
Obesity
Heart Rate
Hypertension
Research

Keywords

  • natriuretic peptide
  • obesity
  • salt intake

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Arora, P., Reingold, J., Baggish, A., Guanaga, D. P., Wu, C., Ghorbani, A., ... Wang, T. J. (2015). Weight loss, saline loading, and the natriuretic peptide system. Journal of the American Heart Association, 4(1), e001265. https://doi.org/10.1161/JAHA.114.001265

Weight loss, saline loading, and the natriuretic peptide system. / Arora, Pankaj; Reingold, Jason; Baggish, Aaron; Guanaga, Derek P.; Wu, Connie; Ghorbani, Anahita; Song, Yanna; Chen-Tournaux, Annabel; Khan, Abigail; Tainsh, Laurel T.; Buys, Emmanuel S.; Williams, Jonathan S.; Heublein, Denise M.; Burnett, John C.; Semigran, Marc J.; Bloch, Kenneth D.; Scherrer-Crosbie, Marielle; Newton-Cheh, Christopher; Kaplan, Lee M.; Wang, Thomas J.

In: Journal of the American Heart Association, Vol. 4, No. 1, 16.01.2015, p. e001265.

Research output: Contribution to journalArticle

Arora, P, Reingold, J, Baggish, A, Guanaga, DP, Wu, C, Ghorbani, A, Song, Y, Chen-Tournaux, A, Khan, A, Tainsh, LT, Buys, ES, Williams, JS, Heublein, DM, Burnett, JC, Semigran, MJ, Bloch, KD, Scherrer-Crosbie, M, Newton-Cheh, C, Kaplan, LM & Wang, TJ 2015, 'Weight loss, saline loading, and the natriuretic peptide system', Journal of the American Heart Association, vol. 4, no. 1, pp. e001265. https://doi.org/10.1161/JAHA.114.001265
Arora P, Reingold J, Baggish A, Guanaga DP, Wu C, Ghorbani A et al. Weight loss, saline loading, and the natriuretic peptide system. Journal of the American Heart Association. 2015 Jan 16;4(1):e001265. https://doi.org/10.1161/JAHA.114.001265
Arora, Pankaj ; Reingold, Jason ; Baggish, Aaron ; Guanaga, Derek P. ; Wu, Connie ; Ghorbani, Anahita ; Song, Yanna ; Chen-Tournaux, Annabel ; Khan, Abigail ; Tainsh, Laurel T. ; Buys, Emmanuel S. ; Williams, Jonathan S. ; Heublein, Denise M. ; Burnett, John C. ; Semigran, Marc J. ; Bloch, Kenneth D. ; Scherrer-Crosbie, Marielle ; Newton-Cheh, Christopher ; Kaplan, Lee M. ; Wang, Thomas J. / Weight loss, saline loading, and the natriuretic peptide system. In: Journal of the American Heart Association. 2015 ; Vol. 4, No. 1. pp. e001265.
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AU - Wu, Connie

AU - Ghorbani, Anahita

AU - Song, Yanna

AU - Chen-Tournaux, Annabel

AU - Khan, Abigail

AU - Tainsh, Laurel T.

AU - Buys, Emmanuel S.

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