Weight loss in men in late life and bone strength and microarchitecture

a prospective study

for the Osteoporotic Fractures in Men (MrOS) Research Group

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Summary: Weight loss in men in late life was associated with lower bone strength. In contrast, weight gain was not associated with a commensurate increase in bone strength. Future studies should measure concurrent changes in weight and parameters of bone strength and microarchitecture and evaluate potential causal pathways underlying these associations. Introduction: Our aim was to determine associations of weight loss with bone strength and microarchitecture. Methods: We used data from 1723 community-dwelling men (mean age 84.5 years) who attended the MrOS study Year (Y) 14 exam and had high-resolution peripheral quantitative computed tomography (HR-pQCT) scans at ≥ 1 skeletal sites (distal tibia, distal radius, or diaphyseal tibia). Weight change from Y7 to Y14 exams (mean 7.3 years between exams) was classified as moderate weight loss (loss ≥ 10%), mild weight loss (loss 5 to < 10%), stable weight (< 5% change), or weight gain (gain ≥ 5%). Mean HR-pQCT parameters (95%CI) were calculated by weight change category using linear regression models adjusted for age, race, site, health status, body mass index, limb length, and physical activity. The primary outcome measure was estimated failure load. Results: There was a nonlinear association of weight change with failure load at each skeletal site with different associations for weight loss vs. weight gain (p < 0.03). Failure load and total bone mineral density (BMD) at distal sites were lower with greater weight loss with 7.0–7.6% lower failure loads and 4.3–5.8% lower BMDs among men with moderate weight loss compared to those with stable weight (p < 0.01, both comparisons). Cortical, but not trabecular, BMDs at distal sites were lower with greater weight loss. Greater weight loss was associated with lower cortical thickness at all three skeletal sites. Conclusion: Weight loss in men in late life is associated with lower peripheral bone strength and total BMD with global measures reflecting cortical but not trabecular parameters.

Original languageEnglish (US)
Pages (from-to)1-10
Number of pages10
JournalOsteoporosis International
DOIs
StateAccepted/In press - Mar 23 2018

Fingerprint

Weight Loss
Prospective Studies
Bone and Bones
Weights and Measures
Weight Gain
Tibia
Bone Density
Linear Models
Tomography
Independent Living
Health Status
Body Mass Index
Extremities
Outcome Assessment (Health Care)
Exercise

Keywords

  • Bone microarchitecture
  • HR-pQCT
  • Men
  • Weight change

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism

Cite this

Weight loss in men in late life and bone strength and microarchitecture : a prospective study. / for the Osteoporotic Fractures in Men (MrOS) Research Group.

In: Osteoporosis International, 23.03.2018, p. 1-10.

Research output: Contribution to journalArticle

for the Osteoporotic Fractures in Men (MrOS) Research Group. / Weight loss in men in late life and bone strength and microarchitecture : a prospective study. In: Osteoporosis International. 2018 ; pp. 1-10.
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abstract = "Summary: Weight loss in men in late life was associated with lower bone strength. In contrast, weight gain was not associated with a commensurate increase in bone strength. Future studies should measure concurrent changes in weight and parameters of bone strength and microarchitecture and evaluate potential causal pathways underlying these associations. Introduction: Our aim was to determine associations of weight loss with bone strength and microarchitecture. Methods: We used data from 1723 community-dwelling men (mean age 84.5 years) who attended the MrOS study Year (Y) 14 exam and had high-resolution peripheral quantitative computed tomography (HR-pQCT) scans at ≥ 1 skeletal sites (distal tibia, distal radius, or diaphyseal tibia). Weight change from Y7 to Y14 exams (mean 7.3 years between exams) was classified as moderate weight loss (loss ≥ 10{\%}), mild weight loss (loss 5 to < 10{\%}), stable weight (< 5{\%} change), or weight gain (gain ≥ 5{\%}). Mean HR-pQCT parameters (95{\%}CI) were calculated by weight change category using linear regression models adjusted for age, race, site, health status, body mass index, limb length, and physical activity. The primary outcome measure was estimated failure load. Results: There was a nonlinear association of weight change with failure load at each skeletal site with different associations for weight loss vs. weight gain (p < 0.03). Failure load and total bone mineral density (BMD) at distal sites were lower with greater weight loss with 7.0–7.6{\%} lower failure loads and 4.3–5.8{\%} lower BMDs among men with moderate weight loss compared to those with stable weight (p < 0.01, both comparisons). Cortical, but not trabecular, BMDs at distal sites were lower with greater weight loss. Greater weight loss was associated with lower cortical thickness at all three skeletal sites. Conclusion: Weight loss in men in late life is associated with lower peripheral bone strength and total BMD with global measures reflecting cortical but not trabecular parameters.",
keywords = "Bone microarchitecture, HR-pQCT, Men, Weight change",
author = "{for the Osteoporotic Fractures in Men (MrOS) Research Group} and Ensrud, {K. E.} and Vo, {T. N.} and Burghardt, {A. J.} and Schousboe, {J. T.} and Cauley, {J. A.} and Taylor, {B. C.} and Hoffman, {A. R.} and Eric Orwoll and Lane, {N. E.} and L. Langsetmo",
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AU - for the Osteoporotic Fractures in Men (MrOS) Research Group

AU - Ensrud, K. E.

AU - Vo, T. N.

AU - Burghardt, A. J.

AU - Schousboe, J. T.

AU - Cauley, J. A.

AU - Taylor, B. C.

AU - Hoffman, A. R.

AU - Orwoll, Eric

AU - Lane, N. E.

AU - Langsetmo, L.

PY - 2018/3/23

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N2 - Summary: Weight loss in men in late life was associated with lower bone strength. In contrast, weight gain was not associated with a commensurate increase in bone strength. Future studies should measure concurrent changes in weight and parameters of bone strength and microarchitecture and evaluate potential causal pathways underlying these associations. Introduction: Our aim was to determine associations of weight loss with bone strength and microarchitecture. Methods: We used data from 1723 community-dwelling men (mean age 84.5 years) who attended the MrOS study Year (Y) 14 exam and had high-resolution peripheral quantitative computed tomography (HR-pQCT) scans at ≥ 1 skeletal sites (distal tibia, distal radius, or diaphyseal tibia). Weight change from Y7 to Y14 exams (mean 7.3 years between exams) was classified as moderate weight loss (loss ≥ 10%), mild weight loss (loss 5 to < 10%), stable weight (< 5% change), or weight gain (gain ≥ 5%). Mean HR-pQCT parameters (95%CI) were calculated by weight change category using linear regression models adjusted for age, race, site, health status, body mass index, limb length, and physical activity. The primary outcome measure was estimated failure load. Results: There was a nonlinear association of weight change with failure load at each skeletal site with different associations for weight loss vs. weight gain (p < 0.03). Failure load and total bone mineral density (BMD) at distal sites were lower with greater weight loss with 7.0–7.6% lower failure loads and 4.3–5.8% lower BMDs among men with moderate weight loss compared to those with stable weight (p < 0.01, both comparisons). Cortical, but not trabecular, BMDs at distal sites were lower with greater weight loss. Greater weight loss was associated with lower cortical thickness at all three skeletal sites. Conclusion: Weight loss in men in late life is associated with lower peripheral bone strength and total BMD with global measures reflecting cortical but not trabecular parameters.

AB - Summary: Weight loss in men in late life was associated with lower bone strength. In contrast, weight gain was not associated with a commensurate increase in bone strength. Future studies should measure concurrent changes in weight and parameters of bone strength and microarchitecture and evaluate potential causal pathways underlying these associations. Introduction: Our aim was to determine associations of weight loss with bone strength and microarchitecture. Methods: We used data from 1723 community-dwelling men (mean age 84.5 years) who attended the MrOS study Year (Y) 14 exam and had high-resolution peripheral quantitative computed tomography (HR-pQCT) scans at ≥ 1 skeletal sites (distal tibia, distal radius, or diaphyseal tibia). Weight change from Y7 to Y14 exams (mean 7.3 years between exams) was classified as moderate weight loss (loss ≥ 10%), mild weight loss (loss 5 to < 10%), stable weight (< 5% change), or weight gain (gain ≥ 5%). Mean HR-pQCT parameters (95%CI) were calculated by weight change category using linear regression models adjusted for age, race, site, health status, body mass index, limb length, and physical activity. The primary outcome measure was estimated failure load. Results: There was a nonlinear association of weight change with failure load at each skeletal site with different associations for weight loss vs. weight gain (p < 0.03). Failure load and total bone mineral density (BMD) at distal sites were lower with greater weight loss with 7.0–7.6% lower failure loads and 4.3–5.8% lower BMDs among men with moderate weight loss compared to those with stable weight (p < 0.01, both comparisons). Cortical, but not trabecular, BMDs at distal sites were lower with greater weight loss. Greater weight loss was associated with lower cortical thickness at all three skeletal sites. Conclusion: Weight loss in men in late life is associated with lower peripheral bone strength and total BMD with global measures reflecting cortical but not trabecular parameters.

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