Weight gain of Kenyan school children infected with hookworm, Trichuris trichiura and Ascaris lumbricoides is improved following once- or twice- yearly treatment with albendazole

L. S. Stephenson, M. C. Latham, Elizabeth Adams, S. N. Kinoti, A. Pertet

Research output: Contribution to journalArticle

95 Citations (Scopus)

Abstract

We studied growth in infected children given one dose (600 mg) or two doses of albendazole per school year. Children were examined and allocated at random within sex by descending hookworm egg count to one of three groups: placebo (n = 93), one dose (1x, n = 96) or two doses (2x, n = 95). Each child was treated and then re-examined and treated 3.6 and 8.2 mo later (Exams 2 and 3). The 1x and 2x groups gained significantly more by Exam 3 than the placebo group in weight (1.1 and 0.9 kg more, respectively), percent weight- for-age (3.3 and 2.7 percentage points more), percent weight-for-height (3.1 and 2.9 percentage points more), percent arm circumference-for-age (2.3 and 2.0 percentage points more) and triceps and subscapular skinfolds but did not differ significantly from each other. The placebo group showed significant decreases between exams (P <0.0002) in percent weight-for-age and percent arm circumference-for-age and no change in percent weight-for-height, whereas the 1x and 2x groups exhibited significant increases (P <0.005). At Exam 3, arithmetic mean egg reduction rates for the 1x and 2x groups were 84 and 95% for hookworm, 42 and 32% for Trichuris and 55 and 87% for Ascaris, respectively. We conclude that one or two doses of albendazole per year resulted in similar growth improvements, despite reinfection, in school-age children in an area where these helminths and poor growth are prevalent.

Original languageEnglish (US)
Pages (from-to)656-665
Number of pages10
JournalJournal of Nutrition
Volume123
Issue number4
StatePublished - 1993
Externally publishedYes

Fingerprint

Trichuris trichiura
Ascaris lumbricoides
Trichuris
Ancylostomatoidea
hookworms
Albendazole
albendazole
school children
Weight Gain
weight gain
Weights and Measures
placebos
dosage
arm circumference
Placebos
Ovum
Growth
Ascaris
Therapeutics
child growth

Keywords

  • ascaris lumbricoides
  • children
  • growth
  • hookworm
  • trichuris trichiura

ASJC Scopus subject areas

  • Food Science
  • Medicine (miscellaneous)

Cite this

Weight gain of Kenyan school children infected with hookworm, Trichuris trichiura and Ascaris lumbricoides is improved following once- or twice- yearly treatment with albendazole. / Stephenson, L. S.; Latham, M. C.; Adams, Elizabeth; Kinoti, S. N.; Pertet, A.

In: Journal of Nutrition, Vol. 123, No. 4, 1993, p. 656-665.

Research output: Contribution to journalArticle

@article{bea878c91987471d98cc6faba5542124,
title = "Weight gain of Kenyan school children infected with hookworm, Trichuris trichiura and Ascaris lumbricoides is improved following once- or twice- yearly treatment with albendazole",
abstract = "We studied growth in infected children given one dose (600 mg) or two doses of albendazole per school year. Children were examined and allocated at random within sex by descending hookworm egg count to one of three groups: placebo (n = 93), one dose (1x, n = 96) or two doses (2x, n = 95). Each child was treated and then re-examined and treated 3.6 and 8.2 mo later (Exams 2 and 3). The 1x and 2x groups gained significantly more by Exam 3 than the placebo group in weight (1.1 and 0.9 kg more, respectively), percent weight- for-age (3.3 and 2.7 percentage points more), percent weight-for-height (3.1 and 2.9 percentage points more), percent arm circumference-for-age (2.3 and 2.0 percentage points more) and triceps and subscapular skinfolds but did not differ significantly from each other. The placebo group showed significant decreases between exams (P <0.0002) in percent weight-for-age and percent arm circumference-for-age and no change in percent weight-for-height, whereas the 1x and 2x groups exhibited significant increases (P <0.005). At Exam 3, arithmetic mean egg reduction rates for the 1x and 2x groups were 84 and 95{\%} for hookworm, 42 and 32{\%} for Trichuris and 55 and 87{\%} for Ascaris, respectively. We conclude that one or two doses of albendazole per year resulted in similar growth improvements, despite reinfection, in school-age children in an area where these helminths and poor growth are prevalent.",
keywords = "ascaris lumbricoides, children, growth, hookworm, trichuris trichiura",
author = "Stephenson, {L. S.} and Latham, {M. C.} and Elizabeth Adams and Kinoti, {S. N.} and A. Pertet",
year = "1993",
language = "English (US)",
volume = "123",
pages = "656--665",
journal = "Journal of Nutrition",
issn = "0022-3166",
publisher = "American Society for Nutrition",
number = "4",

}

TY - JOUR

T1 - Weight gain of Kenyan school children infected with hookworm, Trichuris trichiura and Ascaris lumbricoides is improved following once- or twice- yearly treatment with albendazole

AU - Stephenson, L. S.

AU - Latham, M. C.

AU - Adams, Elizabeth

AU - Kinoti, S. N.

AU - Pertet, A.

PY - 1993

Y1 - 1993

N2 - We studied growth in infected children given one dose (600 mg) or two doses of albendazole per school year. Children were examined and allocated at random within sex by descending hookworm egg count to one of three groups: placebo (n = 93), one dose (1x, n = 96) or two doses (2x, n = 95). Each child was treated and then re-examined and treated 3.6 and 8.2 mo later (Exams 2 and 3). The 1x and 2x groups gained significantly more by Exam 3 than the placebo group in weight (1.1 and 0.9 kg more, respectively), percent weight- for-age (3.3 and 2.7 percentage points more), percent weight-for-height (3.1 and 2.9 percentage points more), percent arm circumference-for-age (2.3 and 2.0 percentage points more) and triceps and subscapular skinfolds but did not differ significantly from each other. The placebo group showed significant decreases between exams (P <0.0002) in percent weight-for-age and percent arm circumference-for-age and no change in percent weight-for-height, whereas the 1x and 2x groups exhibited significant increases (P <0.005). At Exam 3, arithmetic mean egg reduction rates for the 1x and 2x groups were 84 and 95% for hookworm, 42 and 32% for Trichuris and 55 and 87% for Ascaris, respectively. We conclude that one or two doses of albendazole per year resulted in similar growth improvements, despite reinfection, in school-age children in an area where these helminths and poor growth are prevalent.

AB - We studied growth in infected children given one dose (600 mg) or two doses of albendazole per school year. Children were examined and allocated at random within sex by descending hookworm egg count to one of three groups: placebo (n = 93), one dose (1x, n = 96) or two doses (2x, n = 95). Each child was treated and then re-examined and treated 3.6 and 8.2 mo later (Exams 2 and 3). The 1x and 2x groups gained significantly more by Exam 3 than the placebo group in weight (1.1 and 0.9 kg more, respectively), percent weight- for-age (3.3 and 2.7 percentage points more), percent weight-for-height (3.1 and 2.9 percentage points more), percent arm circumference-for-age (2.3 and 2.0 percentage points more) and triceps and subscapular skinfolds but did not differ significantly from each other. The placebo group showed significant decreases between exams (P <0.0002) in percent weight-for-age and percent arm circumference-for-age and no change in percent weight-for-height, whereas the 1x and 2x groups exhibited significant increases (P <0.005). At Exam 3, arithmetic mean egg reduction rates for the 1x and 2x groups were 84 and 95% for hookworm, 42 and 32% for Trichuris and 55 and 87% for Ascaris, respectively. We conclude that one or two doses of albendazole per year resulted in similar growth improvements, despite reinfection, in school-age children in an area where these helminths and poor growth are prevalent.

KW - ascaris lumbricoides

KW - children

KW - growth

KW - hookworm

KW - trichuris trichiura

UR - http://www.scopus.com/inward/record.url?scp=0027506232&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0027506232&partnerID=8YFLogxK

M3 - Article

VL - 123

SP - 656

EP - 665

JO - Journal of Nutrition

JF - Journal of Nutrition

SN - 0022-3166

IS - 4

ER -