Wegener's granulomatosis

John E. Tuhy, Gordon L. Maurice, Nelson R. Niles

Research output: Contribution to journalArticle

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Abstract

Wegener's granulomatosis is characterized by necrotizing granulomatous lesions of the upper respiratory tract and/or lungs, necrotizing vasculitis and focal glomerulonephritis, terminating usually in uremia. Two additional cases are reported, bringing the total in the literature to thirty-seven. In Case I an initial erroneous diagnosis of tuberculosis was made histopathologically from the resected segment of lung and from autopsy material. Death was due to spontaneous subarachnoid hemorrhage complicating arteritis. This complication, and the cerebral lesions found at autopsy in Case II, have not hitherto been reported in this disease. The spectrum formed by this and other conditions closely related to polyarteritis nodosa is discussed. A hypersensitivity mechanism has been inferred by most authors but its nature remains to be elucidated. Treatment of this disease so far has been unsatisfactory.

LanguageEnglish (US)
Pages638-646
Number of pages9
JournalThe American Journal of Medicine
Volume25
Issue number4
StatePublished - Oct 1958
Externally publishedYes

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Granulomatosis with Polyangiitis
Autopsy
Polyarteritis Nodosa
Arteritis
Lung
Uremia
Subarachnoid Hemorrhage
Glomerulonephritis
Vasculitis
Respiratory System
Hypersensitivity
Tuberculosis

ASJC Scopus subject areas

  • Nursing(all)

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Tuhy, J. E., Maurice, G. L., & Niles, N. R. (1958). Wegener's granulomatosis. The American Journal of Medicine, 25(4), 638-646.

Wegener's granulomatosis. / Tuhy, John E.; Maurice, Gordon L.; Niles, Nelson R.

In: The American Journal of Medicine, Vol. 25, No. 4, 10.1958, p. 638-646.

Research output: Contribution to journalArticle

Tuhy, JE, Maurice, GL & Niles, NR 1958, 'Wegener's granulomatosis' The American Journal of Medicine, vol. 25, no. 4, pp. 638-646.
Tuhy JE, Maurice GL, Niles NR. Wegener's granulomatosis. The American Journal of Medicine. 1958 Oct;25(4):638-646.
Tuhy, John E. ; Maurice, Gordon L. ; Niles, Nelson R./ Wegener's granulomatosis. In: The American Journal of Medicine. 1958 ; Vol. 25, No. 4. pp. 638-646
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