Weekly prophylactic urokinase instillation in tunneled central venous access devices

Charles E. Ray, Sadashiv S. Shenoy, Philip L. McCarthy, Karen A. Broderick, John Kaufman

Research output: Contribution to journalArticle

41 Citations (Scopus)

Abstract

PURPOSE: To determine the safety and efficacy of weekly prophylactic urokinase therapy in tunneled central venous access devices (VADs). MATERIALS AND METHODS: A prospective, randomized study was performed in 105 patients who underwent tunneled VAD placement between March 1997 and April 1998. The patients were randomized to receive either twice-daily heparin flushes (14 heparin flushes per week; group A, n = 52) or twice-daily heparin flushes with once-weekly urokinase (UK) instillation (13 heparin flushes, one UK flush per week; group B, n = 53). Patients were followed up by examination and/or interview at 1, 3, and 6 months for signs and symptoms of delayed catheter-related complications. RESULTS: The total number of indwelling catheter-days was similar between groups (5,450 in group A, 5,276 in group B). The total number of infectious complications and fibrin sheaths formed was greater for group A (n = 11; 21.1%) than group B (n = 3; 5.7%) (P = .02). There were no side effects noted from the prophylactic UK administrations. CONCLUSION: Prophylactic UK is advantageous in preventing delayed catheter- related complications.

Original languageEnglish (US)
Pages (from-to)1330-1334
Number of pages5
JournalJournal of Vascular and Interventional Radiology
Volume10
Issue number10
StatePublished - 1999
Externally publishedYes

Fingerprint

Urokinase-Type Plasminogen Activator
Heparin
Equipment and Supplies
Catheters
Indwelling Catheters
Fibrin
Signs and Symptoms
Prospective Studies
Interviews
Safety

Keywords

  • Catheters and catheterization, central venous access
  • Central venous access
  • Urokinase

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Radiological and Ultrasound Technology

Cite this

Weekly prophylactic urokinase instillation in tunneled central venous access devices. / Ray, Charles E.; Shenoy, Sadashiv S.; McCarthy, Philip L.; Broderick, Karen A.; Kaufman, John.

In: Journal of Vascular and Interventional Radiology, Vol. 10, No. 10, 1999, p. 1330-1334.

Research output: Contribution to journalArticle

Ray, Charles E. ; Shenoy, Sadashiv S. ; McCarthy, Philip L. ; Broderick, Karen A. ; Kaufman, John. / Weekly prophylactic urokinase instillation in tunneled central venous access devices. In: Journal of Vascular and Interventional Radiology. 1999 ; Vol. 10, No. 10. pp. 1330-1334.
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