Wavefront sensorless adaptive optics OCT with the DONE algorithm for in vivo human retinal imaging [invited]

Hans R.G.W. Verstraete, Morgan Heisler, Myeong Jin Ju, Daniel Wahl, Laurens Bliek, Jeroen Kalkman, Stefano Bonora, Yifan Jian, Michel Verhaegen, Marinko V. Sarunic

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

In this report, which is an international collaboration of OCT, adaptive optics, and control research, we demonstrate the data-based online nonlinear extremum-seeker (DONE) algorithm to guide the image based optimization for wavefront sensorless adaptive optics (WFSL-AO) OCT for in vivo human retinal imaging. The ocular aberrations were corrected using a multi-actuator adaptive lens after linearization of the hysteresis in the piezoelectric actuators. The DONE algorithm succeeded in drastically improving image quality and the OCT signal intensity, up to a factor seven, while achieving a computational time of 1 ms per iteration, making it applicable for many high speed applications. We demonstrate the correction of five aberrations using 70 iterations of the DONE algorithm performed over 2.8 s of continuous volumetric OCT acquisition. Data acquired from an imaging phantom and in vivo from human research volunteers are presented.

Original languageEnglish (US)
Article number#280260
Pages (from-to)2261-2275
Number of pages15
JournalBiomedical Optics Express
Volume8
Issue number4
DOIs
StatePublished - Apr 1 2017
Externally publishedYes

Fingerprint

homing devices
range (extremes)
adaptive optics
iteration
aberration
Imaging Phantoms
adaptive control
piezoelectric actuators
linearization
Research
Lenses
Volunteers
acquisition
actuators
hysteresis
lenses
high speed
optimization

Keywords

  • Active or adaptive optics
  • Algorithms
  • Optical coherence tomography

ASJC Scopus subject areas

  • Biotechnology
  • Atomic and Molecular Physics, and Optics

Cite this

Verstraete, H. R. G. W., Heisler, M., Ju, M. J., Wahl, D., Bliek, L., Kalkman, J., ... Sarunic, M. V. (2017). Wavefront sensorless adaptive optics OCT with the DONE algorithm for in vivo human retinal imaging [invited]. Biomedical Optics Express, 8(4), 2261-2275. [#280260]. https://doi.org/10.1364/BOE.8.002261

Wavefront sensorless adaptive optics OCT with the DONE algorithm for in vivo human retinal imaging [invited]. / Verstraete, Hans R.G.W.; Heisler, Morgan; Ju, Myeong Jin; Wahl, Daniel; Bliek, Laurens; Kalkman, Jeroen; Bonora, Stefano; Jian, Yifan; Verhaegen, Michel; Sarunic, Marinko V.

In: Biomedical Optics Express, Vol. 8, No. 4, #280260, 01.04.2017, p. 2261-2275.

Research output: Contribution to journalArticle

Verstraete, HRGW, Heisler, M, Ju, MJ, Wahl, D, Bliek, L, Kalkman, J, Bonora, S, Jian, Y, Verhaegen, M & Sarunic, MV 2017, 'Wavefront sensorless adaptive optics OCT with the DONE algorithm for in vivo human retinal imaging [invited]', Biomedical Optics Express, vol. 8, no. 4, #280260, pp. 2261-2275. https://doi.org/10.1364/BOE.8.002261
Verstraete, Hans R.G.W. ; Heisler, Morgan ; Ju, Myeong Jin ; Wahl, Daniel ; Bliek, Laurens ; Kalkman, Jeroen ; Bonora, Stefano ; Jian, Yifan ; Verhaegen, Michel ; Sarunic, Marinko V. / Wavefront sensorless adaptive optics OCT with the DONE algorithm for in vivo human retinal imaging [invited]. In: Biomedical Optics Express. 2017 ; Vol. 8, No. 4. pp. 2261-2275.
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