Wavefront correction and high-resolution in vivo OCT imaging with an objective integrated Multi-actuator Adaptive Lens

Stefano Bonora, Yifan Jian, Pengfei Zhang, Azhar Zam, Edward N. Pugh, Robert J. Zawadzki, Marinko V. Sarunic

Research output: Contribution to journalArticle

43 Citations (Scopus)

Abstract

Adaptive optics is rapidly transforming microscopy and highresolution ophthalmic imaging. The adaptive elements commonly used to control optical wavefronts are liquid crystal spatial light modulators and deformable mirrors. We introduce a novel Multi-actuator Adaptive Lens that can correct aberrations to high order, and which has the potential to increase the spread of adaptive optics to many new applications by simplifying its integration with existing systems. Our method combines an adaptive lens with an imaged-based optimization control that allows the correction of images to the diffraction limit, and provides a reduction of hardware complexity with respect to existing state-of-the-art adaptive optics systems. The Multi-actuator Adaptive Lens design that we present can correct wavefront aberrations up to the 4th order of the Zernike polynomial characterization. The performance of the Multi-actuator Adaptive Lens is demonstrated in a wide field microscope, using a Shack-Hartmann wavefront sensor for closed loop control. The Multi-actuator Adaptive Lens and image-based wavefront-sensorless control were also integrated into the objective of a Fourier Domain Optical Coherence Tomography system for in vivo imaging of mouse retinal structures. The experimental results demonstrate that the insertion of the Multi-actuator Objective Lens can generate arbitrary wavefronts to correct aberrations down to the diffraction limit, and can be easily integrated into optical systems to improve the quality of aberrated images.

Original languageEnglish (US)
Pages (from-to)21931-21941
Number of pages11
JournalOptics express
Volume23
Issue number17
DOIs
StatePublished - Aug 24 2015
Externally publishedYes

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actuators
lenses
adaptive optics
high resolution
aberration
lens design
optical control
deformable mirrors
light modulators
diffraction
mice
insertion
hardware
polynomials
tomography
liquid crystals
microscopes
mirrors
microscopy
optimization

ASJC Scopus subject areas

  • Atomic and Molecular Physics, and Optics

Cite this

Wavefront correction and high-resolution in vivo OCT imaging with an objective integrated Multi-actuator Adaptive Lens. / Bonora, Stefano; Jian, Yifan; Zhang, Pengfei; Zam, Azhar; Pugh, Edward N.; Zawadzki, Robert J.; Sarunic, Marinko V.

In: Optics express, Vol. 23, No. 17, 24.08.2015, p. 21931-21941.

Research output: Contribution to journalArticle

Bonora, Stefano ; Jian, Yifan ; Zhang, Pengfei ; Zam, Azhar ; Pugh, Edward N. ; Zawadzki, Robert J. ; Sarunic, Marinko V. / Wavefront correction and high-resolution in vivo OCT imaging with an objective integrated Multi-actuator Adaptive Lens. In: Optics express. 2015 ; Vol. 23, No. 17. pp. 21931-21941.
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