Wavefront control with a multi-actuator adaptive Lens in imaging applications

J. Mocci, M. Cua, S. Lee, Yifan Jian, P. Pozzi, M. Quintavalla, C. Trestino, H. Verstraete, D. Wahl, R. Muradore, R. J. Zawadzki, M. Verhaegen, M. V. Sarunic, S. Bonora

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

The use of adaptive lenses instead of deformable mirrors can simplify the implementation of an adaptive optics system. The recently introduced Multi-actuator Adaptive Lens (MAL) can be used in closed loop with a wavefront sensor to correct for time-variant wavefront aberrations. The MAL can guarantee a level of correction and a response time similar to the ones obtained with deformable mirrors. The adaptive lens is based on the use of piezoelectric actuators and, without any obstruction or electrodes in the clear aperture, can guarantee a fast response time, less than ∼10ms. Our tests show that the MAL can be used both in combination with a wavefront sensor in a "classical" adaptive optics closed loop, or in a wavefront sensorless configuration. The latter has allowed us to design more compact and simple imaging systems for different microscopy platforms. We will show that the Multi-actuator Adaptive Lens has been successfully used for in-vivo OCT ophthalmic imaging in both mice and humans, as well as confocal and two photon microscopy. We tested and compared different optimization strategies such as coordinate search and the DONE algorithm. The results suggest that the MAL optimization can correct for eye aberrations with a pupil of 5mm or sample induced aberrations in microscopy.

Original languageEnglish (US)
Title of host publicationAdaptive Optics and Wavefront Control for Biological Systems III
EditorsJoel Kubby, Thomas G. Bifano, Sylvain Gigan
PublisherSPIE
ISBN (Electronic)9781510605879
DOIs
StatePublished - Jan 1 2017
Externally publishedYes
EventAdaptive Optics and Wavefront Control for Biological Systems III - San Francisco, United States
Duration: Jan 28 2017Jan 30 2017

Publication series

NameProgress in Biomedical Optics and Imaging - Proceedings of SPIE
Volume10073
ISSN (Print)1605-7422

Conference

ConferenceAdaptive Optics and Wavefront Control for Biological Systems III
CountryUnited States
CitySan Francisco
Period1/28/171/30/17

Fingerprint

Wavefronts
Lenses
Actuators
actuators
lenses
Imaging techniques
Aberrations
aberration
Microscopy
Microscopic examination
Adaptive optics
deformable mirrors
microscopy
adaptive optics
Reaction Time
optimization
piezoelectric actuators
Piezoelectric actuators
sensors
Sensors

Keywords

  • Adaptive Lens
  • Adaptive Optics
  • OCT
  • Wavefront sensorless

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Biomaterials
  • Atomic and Molecular Physics, and Optics
  • Radiology Nuclear Medicine and imaging

Cite this

Mocci, J., Cua, M., Lee, S., Jian, Y., Pozzi, P., Quintavalla, M., ... Bonora, S. (2017). Wavefront control with a multi-actuator adaptive Lens in imaging applications. In J. Kubby, T. G. Bifano, & S. Gigan (Eds.), Adaptive Optics and Wavefront Control for Biological Systems III [1007302] (Progress in Biomedical Optics and Imaging - Proceedings of SPIE; Vol. 10073). SPIE. https://doi.org/10.1117/12.2250016

Wavefront control with a multi-actuator adaptive Lens in imaging applications. / Mocci, J.; Cua, M.; Lee, S.; Jian, Yifan; Pozzi, P.; Quintavalla, M.; Trestino, C.; Verstraete, H.; Wahl, D.; Muradore, R.; Zawadzki, R. J.; Verhaegen, M.; Sarunic, M. V.; Bonora, S.

Adaptive Optics and Wavefront Control for Biological Systems III. ed. / Joel Kubby; Thomas G. Bifano; Sylvain Gigan. SPIE, 2017. 1007302 (Progress in Biomedical Optics and Imaging - Proceedings of SPIE; Vol. 10073).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Mocci, J, Cua, M, Lee, S, Jian, Y, Pozzi, P, Quintavalla, M, Trestino, C, Verstraete, H, Wahl, D, Muradore, R, Zawadzki, RJ, Verhaegen, M, Sarunic, MV & Bonora, S 2017, Wavefront control with a multi-actuator adaptive Lens in imaging applications. in J Kubby, TG Bifano & S Gigan (eds), Adaptive Optics and Wavefront Control for Biological Systems III., 1007302, Progress in Biomedical Optics and Imaging - Proceedings of SPIE, vol. 10073, SPIE, Adaptive Optics and Wavefront Control for Biological Systems III, San Francisco, United States, 1/28/17. https://doi.org/10.1117/12.2250016
Mocci J, Cua M, Lee S, Jian Y, Pozzi P, Quintavalla M et al. Wavefront control with a multi-actuator adaptive Lens in imaging applications. In Kubby J, Bifano TG, Gigan S, editors, Adaptive Optics and Wavefront Control for Biological Systems III. SPIE. 2017. 1007302. (Progress in Biomedical Optics and Imaging - Proceedings of SPIE). https://doi.org/10.1117/12.2250016
Mocci, J. ; Cua, M. ; Lee, S. ; Jian, Yifan ; Pozzi, P. ; Quintavalla, M. ; Trestino, C. ; Verstraete, H. ; Wahl, D. ; Muradore, R. ; Zawadzki, R. J. ; Verhaegen, M. ; Sarunic, M. V. ; Bonora, S. / Wavefront control with a multi-actuator adaptive Lens in imaging applications. Adaptive Optics and Wavefront Control for Biological Systems III. editor / Joel Kubby ; Thomas G. Bifano ; Sylvain Gigan. SPIE, 2017. (Progress in Biomedical Optics and Imaging - Proceedings of SPIE).
@inproceedings{c89adf9f26e74459b577c4c204bbfef4,
title = "Wavefront control with a multi-actuator adaptive Lens in imaging applications",
abstract = "The use of adaptive lenses instead of deformable mirrors can simplify the implementation of an adaptive optics system. The recently introduced Multi-actuator Adaptive Lens (MAL) can be used in closed loop with a wavefront sensor to correct for time-variant wavefront aberrations. The MAL can guarantee a level of correction and a response time similar to the ones obtained with deformable mirrors. The adaptive lens is based on the use of piezoelectric actuators and, without any obstruction or electrodes in the clear aperture, can guarantee a fast response time, less than ∼10ms. Our tests show that the MAL can be used both in combination with a wavefront sensor in a {"}classical{"} adaptive optics closed loop, or in a wavefront sensorless configuration. The latter has allowed us to design more compact and simple imaging systems for different microscopy platforms. We will show that the Multi-actuator Adaptive Lens has been successfully used for in-vivo OCT ophthalmic imaging in both mice and humans, as well as confocal and two photon microscopy. We tested and compared different optimization strategies such as coordinate search and the DONE algorithm. The results suggest that the MAL optimization can correct for eye aberrations with a pupil of 5mm or sample induced aberrations in microscopy.",
keywords = "Adaptive Lens, Adaptive Optics, OCT, Wavefront sensorless",
author = "J. Mocci and M. Cua and S. Lee and Yifan Jian and P. Pozzi and M. Quintavalla and C. Trestino and H. Verstraete and D. Wahl and R. Muradore and Zawadzki, {R. J.} and M. Verhaegen and Sarunic, {M. V.} and S. Bonora",
year = "2017",
month = "1",
day = "1",
doi = "10.1117/12.2250016",
language = "English (US)",
series = "Progress in Biomedical Optics and Imaging - Proceedings of SPIE",
publisher = "SPIE",
editor = "Joel Kubby and Bifano, {Thomas G.} and Sylvain Gigan",
booktitle = "Adaptive Optics and Wavefront Control for Biological Systems III",

}

TY - GEN

T1 - Wavefront control with a multi-actuator adaptive Lens in imaging applications

AU - Mocci, J.

AU - Cua, M.

AU - Lee, S.

AU - Jian, Yifan

AU - Pozzi, P.

AU - Quintavalla, M.

AU - Trestino, C.

AU - Verstraete, H.

AU - Wahl, D.

AU - Muradore, R.

AU - Zawadzki, R. J.

AU - Verhaegen, M.

AU - Sarunic, M. V.

AU - Bonora, S.

PY - 2017/1/1

Y1 - 2017/1/1

N2 - The use of adaptive lenses instead of deformable mirrors can simplify the implementation of an adaptive optics system. The recently introduced Multi-actuator Adaptive Lens (MAL) can be used in closed loop with a wavefront sensor to correct for time-variant wavefront aberrations. The MAL can guarantee a level of correction and a response time similar to the ones obtained with deformable mirrors. The adaptive lens is based on the use of piezoelectric actuators and, without any obstruction or electrodes in the clear aperture, can guarantee a fast response time, less than ∼10ms. Our tests show that the MAL can be used both in combination with a wavefront sensor in a "classical" adaptive optics closed loop, or in a wavefront sensorless configuration. The latter has allowed us to design more compact and simple imaging systems for different microscopy platforms. We will show that the Multi-actuator Adaptive Lens has been successfully used for in-vivo OCT ophthalmic imaging in both mice and humans, as well as confocal and two photon microscopy. We tested and compared different optimization strategies such as coordinate search and the DONE algorithm. The results suggest that the MAL optimization can correct for eye aberrations with a pupil of 5mm or sample induced aberrations in microscopy.

AB - The use of adaptive lenses instead of deformable mirrors can simplify the implementation of an adaptive optics system. The recently introduced Multi-actuator Adaptive Lens (MAL) can be used in closed loop with a wavefront sensor to correct for time-variant wavefront aberrations. The MAL can guarantee a level of correction and a response time similar to the ones obtained with deformable mirrors. The adaptive lens is based on the use of piezoelectric actuators and, without any obstruction or electrodes in the clear aperture, can guarantee a fast response time, less than ∼10ms. Our tests show that the MAL can be used both in combination with a wavefront sensor in a "classical" adaptive optics closed loop, or in a wavefront sensorless configuration. The latter has allowed us to design more compact and simple imaging systems for different microscopy platforms. We will show that the Multi-actuator Adaptive Lens has been successfully used for in-vivo OCT ophthalmic imaging in both mice and humans, as well as confocal and two photon microscopy. We tested and compared different optimization strategies such as coordinate search and the DONE algorithm. The results suggest that the MAL optimization can correct for eye aberrations with a pupil of 5mm or sample induced aberrations in microscopy.

KW - Adaptive Lens

KW - Adaptive Optics

KW - OCT

KW - Wavefront sensorless

UR - http://www.scopus.com/inward/record.url?scp=85020393011&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85020393011&partnerID=8YFLogxK

U2 - 10.1117/12.2250016

DO - 10.1117/12.2250016

M3 - Conference contribution

AN - SCOPUS:85020393011

T3 - Progress in Biomedical Optics and Imaging - Proceedings of SPIE

BT - Adaptive Optics and Wavefront Control for Biological Systems III

A2 - Kubby, Joel

A2 - Bifano, Thomas G.

A2 - Gigan, Sylvain

PB - SPIE

ER -